Efektivitas Pengobatan Topikal pada Pitiriasis Versikolor

Pityriasis versicolor is a chronic mild superficial fungal infection of the skin due to lipophilic fungi Malassezia. It commonly affects the face, neck, abdomen, proximal extremities, axilla, groin, and genitalia. The occurrence of this disease is not influenced by sex, albeit, age influences its incidence since it is more common in adolescents and young adults.Therefore, an effective, safe, and affordable treatment should be considered. The first-line therapy for pity-riasis versicolor is topical treatment, classified into specific and non-specific antifungal agents. This study was aimed to determine the efficacy of topical treatment in pityriasis versicolor. This was a literature review study using three databases, namely PubMed, ClinicalKey, and Google Scholar and the keywords of "topical treatment AND pityriasis versicolor". The results obtained 10 literatures that fulfilled the inclusion and exclusion criteria. Theseliteratures discussed about the efficacy of topical treatment in patients with pityriasis versicolor based on clinical and mycological cure rate and the highest percentage was more than 80% in each study. In conclusion, topical treatment was effective for pityriasis versicolor.Keywords: topical treatment, pityriasis versicolor Abstrak: Pitiriasis versikolor adalah penyakit jamur superfisial ringan akibat infeksi kulit kronis oleh jamur lipofilik genus Malassezia. Infeksi ini biasanya ditemukan pada wajah, leher, perut, ektremitas proksimal, aksila, lipat paha, dan genitalia. Kejadian penyakit ini tidak dipengaruhi oleh jenis kelamin, tetapi dapat dipengaruhi oleh usia, yaitu lebih banyak terjadi pada remaja dan dewasa muda. Pengobatan topikal merupakan terapi lini pertama untuk pitiriasis versikolor dan dibagi menjadi agen antijamur nonspesifik dan agen antijamur spesifik. Penelitian ini bertujuan untuk mengetahui efektivitas pengobatan topikal pada pitiriasis versikolor. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu PubMed, ClinicalKey, dan Google Scholar. Kata kunci yang digunakan yaitu “topical treatment AND pityriasis versicolor”.Hasil seleksi berdasarkan kriteria inklusi dan eksklusi mendapatkan 10 literatur. Kasjian literatur penelitian menunjukkan efektivitas penggunaan pengobatan topikal pada pitiriasis versikolor berdasarkan penyembuhan klinis maupun penyembuhan mikologis dengan persentase tertinggi mencapai angka >80% pada masing-masing literatur. Simpulan penelitian ini ialah pengobatan topikal pada pitiriasis versikolor terbukti efektif.Kata kunci: pengobatan topikal, pitiriasis versikolor

Evaluation of mycological cure of Unani medicine vs modern medicine: A comparative clinical trial

Introduction: Qooba (Dermatophytosis) is a clinical condition caused by fungal infection of skin in humans and other vertebras. The fungi that cause dermatophytosis feed on keratin, the material found in the outer layer of skin, hair and nails. Aims & objective: The purpose of this study was to evaluate mycological cure of Unani medicine in comparison with Modern medicine. Methods: The study was conducted on 60 cases of qooba (dermatophytosis). Patients were randomly allocated to test (A) and control (B) groups. Group A patients were given Unani medicines ‘zimad daad’ and 'naqooh shahtara’ while, group B patients were treated with allopathic medicines. The duration of treatment was fixed as 30 days. Results & Discussion: All the patients were kept under strict observation and assessment for mycological cure rate was done weekly. At the end of the study clinical and statistical results demonstrate the efficacy of naqooh shahtara and zimad daad in the mycological cure of fungal infections. The effect of drug on mycological cure of disease was found to be extremely significant. Conclusion: The combination can also serve as mycological cure for fungal infections without any apparent side effects.

A comparative clinical study on efficacy of terbinafine and griseofulvin in patients with tinea corporis

Background: The objective of the present study was to compare the efficacy of terbinafine and griseofulvin in patients with tinea corporis in a tertiary care hospital, Madurai.Methods: About 60 patients are selected from the outpatient department of Dermatology according to inclusion and exclusion criteria. They were divided into 2 groups of 30 patients each. Group 1 received tab. terbinafine 250 mg OD and group 2 received 250 mg BD for 4 weeks. All patients were investigated at baseline, end of 2nd week and at end of 4 weeks. Effectiveness of both the drugs were determined by achieving clinical as well as mycological cure. The results were recorded, tabulated and analysed using student’s t test.Results: Patients in group 1 showed higher clinical and mycological cure rate when compared with group 2.Conclusions: Oral terbinafine is the effective antifungal agent in the treatment of extensive tinea corporis infection.

Efficacy of topical terbinafine and clotrimazole in the treatment of dermatophytoses: a Clinical and Microbiological Comparision

Background: Dermatophytoses have a high prevalence worldwide and also in Nepal. Large scale studies with different antifungal agents for long fol¬low up periods to assess the long term outcome of treatments together with culture sensitivity testing are required to confirm the elimination of the fungi. Materials and Methods: Total of 97 patients were enrolled, 48 patients received treatment with terbinafine 1% cream for 2 weeks and 49 patients received clotrimazole 1% cream for 4 weeks. Clinical evaluation and microscopic examination of the potassium hydroxide (KOH) mount were done at presentation, at week 2 and at week 4. Clinical assessment scoring (CAS) and Mycological cure rate were compared between the study groups. Results: Terbinafine cured more cases of dermatophytoses compared to clotrimazole. The clinical cure rate was not statistically different among cases of tinea pedis. Terbinafine was better among cases of tinea cruris and tinea corporis only at the end of week 4. Mycological cure rate was higher for terbinafine both at the end of week 2 and week 4.

A Comparison of Itraconazole and Griseofulvin in the Treatment of Tinea Corporis and Tinea Cruris: A Double-Blindb Study

A total of 40 patients with clinically and mycologically documented tinea corporis or tinea cruris were treated with 100 mg/day itraconazole ( n = 19) or 500 mg/day griseofulvin ( n = 21) for 15 days. Of the itraconazole-treated patients, 83.3% were healed or markedly improved, i.e. ‘responders', after 15 days compared with 85.7% of griseofulvin-treated patients. At 15 days after the end of treatment, 88.2% of itraconazole- and 80.9% of griseofulvin-treated patients were classed as ‘responders'. The mycological cure rate (both microscopy and culture negative) was generally lower than the clinical response rate. Both treatments were equally effective at the end of 15 days' treatment with 66.7% of patients cured, but itraconazole was superior to griseofulvin at the 15-day follow-up visit (77.8% of itraconazole-treated patients compared with 66.7% of griseofulvin-treated patients were cured). Both therapies were well tolerated; only one patient treated with itraconazole reported minor side-effects (dizziness, headache and gastro-intestinal disturbances). The results confirm those of earlier comparative trials and suggest that griseofulvin-treated patients are more at risk of relapse than are itraconazole-treated patients.