A healthy eating plan for employees engaged in oil and gas exploration and production in the Far North

Proper nutrition is undoubtedly one of the most important factors of good health. Currently, the priority field of study for the Russian nutritionists is the development of well-balanced nutrition plans which can help to prevent or alleviate the most common medical conditions and work-related diseases. Extensive research has been carried out for the stateled program for the Development of Hydrocarbon Resources in the Northern Regions of Russia, including the Far North, where the huge oil and gas fields are located, and the specialists of Art-Life scientific production association have developed a healthy eating plan to help people working in the Far North maintain general well-being.

The peculiarities of archival heuristics in seeking information on the history of Soviet industry of Sevastopol in the central archives (on the example of the source complex on the history of Sevastopol branch of the Central Research Institute “Compass” in the Central State Archive of Scientific and Technical Documentation of St. Petersburg)

The subject of this research is the information potential of the source complex of archival documents dedicated to the history of Sevastopol Central Research Institute “Compass” in the Central State Archive of Scientific and Technical Documentation of St. Petersburg. Since Sevastopol was not only an industrial, but also a scientific and technological center, the engineering departments lead unique developments, which were later implemented in various sectors nationwide. Both, enterprises and engineering departments were integrated into a unified all-Union system, which justifies using not only the city archive, but also central archives to find sources on the history of industrial development of Sevastopol during the Soviet period. This article is dedicated to determination and detailed analysis of the documents related to the history of Sevastopol Central Research Institute “Compass”. The authors dwell on the types of the preserved departmental documents, provide explicit examples, and analyze the peculiarities of documentation. The work is based on the range previously unpublished archival documents. The conclusion is made that materials from the fund of the Central Research Institute “Compass” of the Central State Archive of Scientific and Technical Documentation of St. Petersburg demonstrates the place and role of Sevastopol branch within the system of this organization, unlike the local documents stored the city archive of Sevastopol, which are focused on the local tasks and problems, and do not fully reflect the structural issues of the entire Scientific Production Association. Analyzing the extracted archival information on the Scientific Production Association “Compass”, the authors conclude that both the association itself and the Ministry of Shipbuilding Industry of the Soviet Union were focused on strengthening integration and interrelation of enterprises both within the Central Research Institute “Compass “ and industry as a whole, which manifested in establishment of the Council of the Scientific Production Association “Compass”; its documents are also stored in the fund.

PIONEERS OF FOREST BREEDING IN THE CENTRAL BLACK EARTH REGION

The article contains brief information from the life and scientific work of the founders of forest breeding, who worked in Voronezh. On the initiative of N.P. Kobranov in 1919, on the basis of Voronezh Agricultural Institute, a forestry department was opened, which was later transformed into the forestry faculty, and since 1930 Voronezh Forestry Institute (now VSUFT) was organized. The main scientific work of N.P. Kobranov is the country's first publication on forest selection - the monograph “Oak selection” (1925), which also outlined possible ways of selection development of forest woody plants in general. Further, his associates and colleagues were engaged in the introduction and selection of forest tree species in the pre-war period: O.G. Kapper ("Study of ecotypes of tree species", 1946; "Conifers", 1954, etc.) and S.A. Samofal (manuscript of his doctoral dissertation "Heredity and variability of forest species and their importance for forest growing", 1938, etc.). Then a huge contribution to the development of forest breeding in the country was made by M.M. Veresin ("Forest seed production", 1963; "Centennial experience of afforestation in the Savalsky forestry", 1963; "Forests of Voronezh", 1971; a new program for forest selection for universities, 1966, etc.). He is the author of grandiose experiments on the geographical planting of Scots pine on an area of about 40 hectares, including more than 350 origins. In addition, he created oak, nut, Karelian birch, seed plantations and collections of hybrids of different tree species. He developed a number of new highly productive poplar hybrids. The director of the Voronezh Forestry Institute V.I. Rubtsov, who himself laid large-scale experimental field facilities for Scots pine forest plantations. Vasily Ivanovich played an important role in the creation of Central Institute of Forest Genetics and Breeding in Voronezh. Among the well-known successors of forest selection work in the country is the director of All-Union Scientific Production Association "Soyuzlesselektsiya" A.I. Iroshnikov. Under him (together with Voronezh Forestry Institute and the Central Research Institute of Forest Genetics and Breeding), a department of forest selection was organized. All these scientists have shown an example of selfless service to the chosen cause

DEVELOPMENT OF A METHOD TO DETERMINE RELATED IMPURITIES IN BROMIDE 1-(β-PHENYLETHYL)-4-AMINO-1,2,4-TRIAZOLE TABLETS

Aim: to develop a modern method to determine related impurities in bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole tablets by high performance liquid chromatography (HPLC). Methods: The development of a method to determine related impurities in bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole tablets involved an already developed method for the determination of 4-amino-1,2,4-triazole impurities in tablets by HPLC. The test solution and the comparison solution were prepared and chromatographed alternately according to the developed methods. At least three chromatograms were obtained for each solution for the purpose of the reliability of the study results. Results: Scientists of the Scientific-Production Association "Farmatron" jointly with the staff of the Pharmaceutical Chemistry Department of Zaporizhzhia State Medical University under the leadership of Professor Mazur I. A. obtained a new original compound – bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole (conditional name "Hypertril"), which exhibits antihypertensive, anti-ischemic and antioxidant properties. It is known that the quality of medicines largely depends on the degree of their purity. Therefore, in accordance with the regulatory documentation and quality control methods of medicines, it is mandatory to carry out tests for impurities. According to the results, the content of impurities of 4-amino-1,2,4-triazole in the tested tablets of bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole is in the range from 0.049 % to 0.195 % which meets the requirements of regulatory documentation. No peaks of unidentified impurities were detected on the chromatograms of the test solution. Conclusion: Therefore, a modern method to determine the related impurity of 4-amino-1,2,4-triazole in tablets of bromide 1-(β-phenylethyl)-4-amino-1,2,4-triazole has been developed. The methodology is reproducible, accurate and meets the requirements of regulatory documentation.

STUDY OF ENDOTHELIOPROTECTIVE ACTION OF COMBINED MEDICINE UNDER ALCOHOLIC CARDIOMYOPATHY

At present, due to spreading of alcoholic cardiomyopathy among the able-bodied population of industrialized countries, there is an urgent need to search for new medicines possessing a strictly targeted effect, taking into account the complex mechanisms of the damaging effects produced by ethyl alcohol on the myocardium. Therefore, the combination of L-arginine and thiotriazolin (developed by “Farmatron” scientific production association) is of great clinical interest. The same is relevant for Mildronate, Mexidol and Thiotriazolin. The aim of this research was to study the endothelioprotective effect of the medicine combining L-arginine with thiotriazoline (4: 1) (Argitril) in comparison with the standard metabolites as Mildronate, Mexidol, and Thiotirazoline on the morphological and functional characteristics of endotheliocytes and ST2 level in modelled cardiomyopathy and alcohol cardiomyopathy. Alcoholic cardiomyopathy was caused by intragastric administration of 20% ethanol solution in a dose of 8 g/kg for 90 days. All animals were divided into 5 groups, 10 animals in each. All the studied substances were administered intraperitoneally for 30 days: the combined medicine (L-arginine 100 mg/ml + thiotriazolin 25 mg/ml (4:1)) - 200 mg/kg (in recalculation for L-arginine); Mildronate (Grindeks, Latvia) - 250 mg/kg; Mexidol (NPK Farmasoft, Russia) - 200 mg/kg, Thiotriazolin (Galichfarm, Ukraine) - 50 mg/kg. The control and intact groups received physiological saline. The following indicators were assessed: endothelial cell nucleus area (μm2); the density of the nuclei of endotheliocytes (as an indicator for the number of cell nuclei per 1 mm2 of myocardial tissue area) and the relative area of endotheliocytes (%), ST2 protein. The study has shown that on the 30th day after 90 days of the development of alcohol addiction, the animals were found out to have alcoholic cardiomyopathy. A significant decrease, by 32.38%, in the area of the nuclei of endotheliocytes was observed in the animals of the test group, the density of nuclei of the endotheliocytes lowered by 7% and the relative area of the nuclei of the endotheliocytes reduced by 21.89%. An increase in the concentration of ST2 protein was observed in 3.34 times compared with the intact animals that evidences the presence of endothelial dysfunction. It has been experimentally proved that the combination of L-arginine/thiotriazolin significantly exceeds the reference medicines as Mildronate, Mexidol and Thiotriazolin in terms of endothelioprotective and cardioprotective effects (effect on the area and density of nuclei of endotheliocytes; concentration of ST2 protein).