Development of High Performance Liquid Chromatographic Estimation of Domperidone and Lansoprazole

The combination of Domperidone and Lansoprazole is very useful in Gastro-esophageal disinfection (Dyspepsia). These methods provide means to separate the components characterize and quantify the components. An accurate, precise, specific and simple HPLC method was developed for simultaneous estimation of Domperidone and Lansoprazole. By this method retention time, linearity and accuracy data is respectively found for Domperidone and Lansoprazole. Mobile phase was prepared by mixing 51 volume of Acetonitrile and 49 volume of Ammonium Acetate (51:49 V/V) then 25mg each of Domperidone and Lansoprazole was dissolved in small volume of Acetonitrile: Ammonium Acetate (51:49 V/V) separately. Retention time was recorded 4.330 ± 0.003 minute and 5.820 ± 0.003 minute for Domperidone and Lansoprazole with 1.0 ml/min flow rate. The low value of % R.S.D indicates that this method is precise and accurate. Thus it can be concluded that the proposed method was good approach for obtaining reliable result.

3D-Simulation Data-Making Trial to present and analyze Small-sized Farmlands Fields with Car-shaped Robot, ROS2, SLAM and Foxy for Real agricultural workers

In this study, we create various application systems focusing on agricultural (agri-) field data digitalization issues that will benefit traditional agri-researchers, workers, and their respective managers. We obtain three-dimensional (3D) information on agri-environments (e.g., rice fields, farmlands) via roaming robots with sensors. Robot-controlled middleware, such as robot operating systems (ROS), are often used for such robots. Thus, we selected car-shaped robot (NANO-RT1), ROS2, and the SLAM-based system. The car-shaped robot-based system operates sensor units uniformly. With this technology, we can recognize our location at an unknown place, and the robot can run. There are challenges in accurately presenting quantitative accuracy data for this type of study. We address this by providing average and standard deviation (SD) data for certain situations using five algorithms: (1) Hector-SLAM, (2) G-mapping, (3) Karto-SLAM, (4) Core-SLAM, and (5) Lago-SLAM. We believe the proposed holistic system has the potential to improve not only agri-businesses, but also agri-skills and overall security levels.

NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data

Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly challenging. This challenge is primarily due to three dominant factors: data accuracy, data scarceness, and problem complexity. Here, we showcase that “shallow” convolutional neural network (CNN) architectures are adequate to deal with the problem complexity imposed by the length variations of TCRs. We demonstrate that current public bulk CDR3β-pMHC binding data overall is of low quality and that the development of accurate prediction models is contingent on paired α/β TCR sequence data corresponding to at least 150 distinct pairs for each investigated pMHC. In comparison, models trained on CDR3α or CDR3β data alone demonstrated a variable and pMHC specific relative performance drop. Together these findings support that T-cell specificity is predictable given the availability of accurate and sufficient paired TCR sequence data. NetTCR-2.0 is publicly available at https://services.healthtech.dtu.dk/service.php?NetTCR-2.0.

Non-identical cognates yield facilitation in translation – does the way foreign vocabulary is learned affect its processing?

Cognates (words sharing form and meaning across languages, e.g. Polish–English FILM–FILM (identical cognates) or TUNNEL–TUNEL (non-identical cognates)) are processed faster than single-language words (cognate facilitation effect), which is modulated by a number of factors. Here, we extended the study reported by Lijewska and Chmiel (2015) and tested the influence of learning experience on non-identical cognate processing in a translation task in 2 experiments with Polish-German–English trilinguals and with German–English bilinguals. The trilinguals learned English and German via Polish, whereas the bilinguals learnt English via German. They translated Polish–English non-identical cognates (MUSZTARDA–SENF–MUSTARD), German–English non-identical cognates (TRAWA–GRAS–GRASS) and controls from English into Polish and into German (trilinguals) or only into German (bilinguals). We found no evidence for the influence of learning experience on cognate processing but the novel finding was a reliable facilitation effect obtained when only non-identical cognates were tested in a translation task with trilinguals (in the accuracy data) as well as with bilinguals (in translation latencies). Additionally, the reported study pointed to the important role of language proficiency in processing.

Advances in TVA-based visual attention research: Moving towards more naturalistic stimuli and game-like tasks

The theory of visual attention, “TVA”, is an influential and formal theory of attentional selection. It is widely applied in clinical assessment of attention and fundamental attention research. However, most TVA-based research is based on accuracy data from letter report experiments performed in controlled laboratory environments. While such basic approaches to questions regarding attentional selection are undoubtedly useful, recent technological advances have enabled the use of increasingly sophisticated experimental paradigms involving more realistic scenarios. Notably, these studies have in many cases resulted in different estimates of capacity limits than those found in studies using traditional TVA-based assessment. Here we review recent developments in TVA-based assessment of attention that goes beyond the use of letter report experiments and experiments performed in controlled laboratory environments. We show that TVA can be used with other tasks and new stimuli, that TVA-based parameter estimation can be embedded into complex scenarios, such as games that can be used to investigate particular problems regarding visual attention, and how TVA-based simulations of “visual foraging” can elucidate attentional control in more naturalistic tasks. We also discuss how these developments may inform future advances of TVA.

Development of derivative spectrophotometric method for simultaneous determination of pyrazinamide and rifampicin in cubosome formulation

The ultraviolet spectrophotometry analysis for quantitative assay of drugs is a method accurate, sensitive, selective and reproductive with the advantage of being a simple and less expensive method. In this study, a derivative ultraviolet spectrophotometric method was developed for simultaneous determination of pyrazinamide (PYZ) and rifampicin (RIF). The spectrophotometric method was evaluated according to validation guidelines for specificity, linearity, limits of detection and quantification, precision, accuracy and robustness. The first-derivative spectra were obtained and by the zerocrossing point, the wavelength 247 nm and 365 nm were selected for PYZ and RIF quantification, respectively. No interference from cubosome excipients was detected in the proposed method. The results demonstrated linearity in a range of 4.0 – 12.0 µg/mL with an adequate correlation coefficient for both drugs. The intra and inter-day precision results (RSD < 5%) indicated the reproducibility of the method. The accuracy data showed satisfactory results (RSD < 5%) from recovery test. In addition, the robustness results showed that the PYZ and RIF content were unaffected by the solvent alteration of methanol to methanol:water (99:1, v/v). The derivative ultraviolet spectrophotometric method proved to be an excellent strategy for simultaneous determination of PYZ and RIF.

Nursing Diagnosis for Potential Organ Donors: Accuracy Study

The objective was to analyze the diagnostic accuracy of Impaired physiological balance syndrome in potential brain-dead organ donors. It is a study of diagnostic accuracy. Data was retrospectively collected from 145 medical records through the filling out of an instrument containing 25 indicators of the nursing diagnosis (ND). Descriptive and inferential statistics were used. The prevalence of the ND was 77 (53.1%). The indicator with the best measures of accuracy was altered heart rate. Therefore, it has the best predictive capacity for determining the ND. It was identified that the absence of the indicators altered heart rate, hyperglycemia, and altered blood pressure is associated with the absence of the ND, while the presence of the indicators hyperthermia, hypothermia, and altered heart rhythm is associated with the presence of the ND. Accurate indicators will assist in diagnostic inference and the interventions and results will have greater chances of targeting and effectiveness.

L1 congruency, word frequency, collocational frequency, L2 proficiency, and their combined effects on Chinese–English bilinguals’ L2 collocational processing

Aims: The current study investigated the effects of first language (L1) congruency, word frequency, collocational frequency, second language (L2) proficiency, and their combined effects on L2 collocational processing. Methodology: Twenty English native speakers and 60 adult Chinese–English bilinguals (intermediate and advanced) completed an online phrasal decision task. They made a judgment about whether target word pairs (congruent collocations, incongruent collocations, and non-collocational baseline items) were commonly used in English. Data and analysis: Response time and accuracy data were analyzed with mixed-effects models, with focus on the interactions of the variables of interest. Findings: Results demonstrated differential effects for the response time and accuracy data: (1) both L2 groups were significantly more accurate but not significantly faster in judging the congruent collocations than the incongruent collocations, and unexpectedly similar patterns were observed with the L1 group; (2) all participants were sensitive to word frequency and collocational frequency, but they differed in the manner and degree of such sensitivity; and (3) the processing of incongruent collocations showed greater combined effects of word frequency and collocational frequency than did the processing of congruent collocations. Originality: We specifically investigated the effects of multiple influencing factors and their combined effects. In addition, we addressed a methodological limitation regarding stimuli control by using congruent and incongruent collocational pairs that differed in only one constituent word. Implications: Our findings highlight the non-colinear relationship of L2 proficiency and (explicit and implicit) collocational knowledge as well as the semantic aspects of cross-language differences, and they also support the usage-based models.

Telemedicine for silent hypoxia: Improving the reliability and accuracy of Max30100-based system

<span lang="EN-US">This study aims to design, assess, and improve the reliability of the telemedicine-based system for examination and monitoring of the symptoms of silent hypoxia–an extraordinary symptom of COVID-19. We design a telemedicine system for heart rate and oxygen saturation measurement which consists of a photoplethysmograph Max30100 sensor, NodeMCU microcontroller, real-time clock module, firebase realtime database, and Android-based mobile application. The designed system is tested through a comparative test with a commercially available oximeter. A total of 85 experiments from 40 participants in two different positions were conducted. Our analysis shows the accuracy rate of the Max30100 measurement is 97.11% and 98.84%, for heart rate and oxygen saturation (SpO₂), respectively. Bland Altman was used to appraising and visualizing the agreement between the two measurement devices. We further apply calibration to improve the accuracy of the collected data through linear regression, which reveals 97.14% and 99% accuracy data for heart rate and SpO₂, respectively. Finally, a series of end-to-end remote testing is successfully conducted representing the real-life scenario of the telemedicine system. Overall, the designed system attains a reliable option for a telemedicine-based system for examination of the symptoms of silent hypoxia.</span>