Early career attrition from teaching disrupts school continuity, precludes many of those who leave the profession from achieving expertise, and drains limited economic resources from educational systems. Because low resource schools experience higher levels of teacher attrition, the phenomenon also contributes to inequitable educational opportunities for socioeconomically disadvantaged students. Although reducing premature attrition is an important policy objective, rates of teacher attrition have remained elevated and stable for at least the last two decades. In a cluster randomized controlled trial design (N=98), we examined the impact of a nine-week meditation-based intervention (MBI) that was integrated into undergraduate preservice teacher education on persistence in the teaching profession three-years later. Participants assigned to the MBI were six times more likely to still be teaching three-years into their career (Odds Ratio=6.05, 95% CI[1.83, 25.37], p=.002). Benefit-cost analysis indicated that integrating a MBI into preservice teacher education incurs minimal costs on the teacher education program but yields substantial predicted savings to educational systems with $2.6 return on every dollar invested. Implications for teacher education and teacher learning are discussed.