An Ethical and Societal Analysis for Biotechnological Methods in Plant Breeding

Technological developments in plant breeding, notably cisgenesis and gene editing, require a rethinking of biotechnology policies. In addition to legal debates about the definition of genetic modification in the Cartagena Protocol and at national and supra-national levels, and debates about the safety of the resulting products for mankind and environment, discussions are ongoing in society concerning ethical and societal questions. In this paper, we analyse the main ethical issues that need to be taken into account when evaluating contemporary plant breeding techniques. After a brief description of the state of the art in plant breeding, we discuss these main ethical issues. We take Consequentialist, Deontological and Virtue ethics as bases of our analysis. This results in a generally positive approach to gene editing, but also highlights several concerns, predominantly used by particular groups in society. This leads to a moral incentive toward transparency and options for operationalizing consumer choice.

Disharmonized the Regulation of Biological Resources and its Ecosystem in Indonesia

The goal of state control over natural resources is an anticipatory step to avoid the widest possible use by individuals or legal entities as a means of oppression and exploitation of others. However, in reality, many regulations overlap and are not in harmony with one another. The author of this study uses normative juridical research. The definition of normative juridical is a type of research that emphasizes more on library research, where the materials used will be obtained from laws, literature, mass media, which are related to writing materials. This study found that the arrangement of living natural resources in Indonesia that is less harmonious is: a. Law Number 21 of 2004 concerning Ratification of the Cartagena Protocol On Biosafety To The Convention On Biological Diversity and b. Constitutional Court Decision No.35/PUU-X/2012.

FOOD SAFETY OF GENETICALLY MODIFIED ORGANISM ACCORDING TO INTERNATIONAL LAW AND ITS IMPLEMENTATION IN INDONESIA

Modern biotechnology products have provided considerable benefits for improving human life and well-being, both in the agriculture, food, industry and human health sectors, as well as in the environmental field. But there are concerns that modern biotechnology products, in addition to providing benefits, also have risks that have adverse impacts on the conservation and sustainable use of biodiversity and human health. Therefore, steps need to be taken, both legally, administratively, and technology to ensure the level of biological safety.This study aims to explain and analyze the safety of Genetically Modified Organism or GMO according to international law and their implementation in Indonesia. The problem approach used in this research is normative law (library research). The data used are secondary data obtained from international, national legal regulations and literature data related to material that supports discussion of the problem. Analysis of the data used is descriptive qualitative.The results of research on food safety of Genetically Modified Organism or GMO according to international law, are regulations on food safety of genetically engineered products regulated in the Convention on Biological Diversity and the Cartagena Protocol on Biosafety. The laws and regulations governing GMO food in Indonesia are good enough because they have carried out the mandate and did not deviate from the biodiversity convention and Cartagena protocol by passing legislation regulations from the legal level to the decision level of the head of BPOM. It’s just that for rules regarding GMO food that is sold in retail, or that is not in the form of packaging, there is still no technical rules that can answer the problems in the field.

Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research

The progress in gene drive research has made the possibility of a future release in the environment probable. This prospect is raising new questions related to the adequacy of the policy frameworks in place to manage and regulate the research and its outcomes responsibly. A number of international mechanisms are exploring how to evaluate this technology. Amongst them, the Convention of Biological Diversity and the Cartagena Protocol, the review mechanisms of the World Health Organisation, and the International Union for Conservation of Nature are offering international fora for dialogue, while regional entities, such as the African Union, are developing specific frameworks to build their preparedness for oversight of gene drive organisms. In this manuscript, we review the existing regulatory landscape around gene drive research and map areas of convergence and divergence, as well as gaps in relation to guidelines for community engagement in gene drive research.

PERLINDUNGAN HUKUM SUMBER DAYA GENETIK INDONESIA DAN OPTIMALISASI TEKNOLOGI INFORMASI

ABSTRAKIndonesia menyimpan sumber daya genetik yang melimpah namun memiliki kelemahan dalam database nya. Hal ini menjadi celah adanya tindakan biopiracy dari perusahaan-perusahaan farmasi negara maju. Perkembangan teknologi informasi memasuki era teknologi 4.0 dan society 5.0. Perlindungan hukum sumber daya genetik dari sisi regulasi dan kelembagaan serta optimalisasi teknologi informasi dalam perlindungan non yuridis Metode penelitian yang digunakan yaitu yuridis normatif dengan pendekatan dekriptif analisis. Data dikumpulkan melalui studi pustaka dan wawancara dan dianalisis dengan metode yuridis kualitatif. Indonesia belum memiliki aturan khusus mengenai sumber daya genetik. Konvensi Keanekaragaman Hayati, Propokol Cartagena dan Protokol Nagoya belum optimal karena tidak didukung oleh negara maju yang menerapkan standard ganda. Perkembangan teknologi infomrasi menjadi peluang sekaligus tantangan. Teknologi informasi dapat menjadi sarana penyusunan database sumber daya genetik yang melimpah dan beragam. Pemanfaatan teknologi informasi menjadi mutlak dilakukan dan dapat menjadi sarana pembuktian secara elektronik serta upaya pencegahan klaim dari negara lain.Kata kunci: genetik; Indonesia; keragaman; informasi; teknologiABSTRACT Indonesia stores abundant genetik resources but has weaknesses in its database. This becomes a gap in the biopiracy of the pharmaceutical companies in developed countries. The development of information technology entered the era of technology 4.0 and society 5.0. Legal protection of genetik resources in terms of regulation and institutions as well as optimization of information technology in non-juridical protection.The research method used is juridical normative with descriptive analysis approach. Data was collected through literature study and interviews and analyzed using qualitative juridical methods.Indonesia does not yet have specific rules regarding genetik resources. The Convention on Biological Diversity, the Cartagena Protocol and the Nagoya Protocol are not yet optimal because they are not supported by developed countries that apply double standards. The development of information technology is both an opportunity and a challenge. Information technology can be a means of compiling a database of abundant and diverse genetik resources. The use of information technology is absolutely necessary and can be a means of proving electronically and efforts to prevent claims from other countries.Keywords: diversity; genetic; Indonesian; information; technology

Golden Rice to Eradicate the Vitamin A Deficiency in the Developing Countries

The development of Golden Rice recently has taken longer than foreseen. Vitamin deficiency is a major medical issue that influences millions of people worldwide. UN Cartagena protocol for biosafety delayed particularly by deferring the determination of phenotypes developed in the open field. In this way, Golden Rice has not possessed the capacity to help with combatting vitamin an insufficiency as golden rice demonstrates fighting hidden hunger, as rice is the dominant crop in most of the Asian countries also staple food so people mostly rely on rice as energy source. Iron, zinc and vitamin A dearth are more dominant in rice consuming countries its named hidden hunger and it affects two billion people worldwide. VAD affect 190 million children and 19 million pregnant women worldwide, 100 grams of uncooked Golden Rice are able to supply up to 57 percent of the estimated average requirement (EAR) for vitamin A of pre-school children and from 38-47 percent of the EAR for pregnant and lactating women so far so good Golden rice passed rigorous biosafety assessment in Philippine. To get a working pro-vitamin A (beta-carotene) biosynthetic pathway in rice endosperm, we presented in a solitary, joined change exertion the cDNA coding for phytoene synthase (psy) and lycopene b-cyclase (b-lcy) both from Narcissus pseudonarcissus and both under the control of the endosperm-particular glutelin promoter together with a bacterial phytoene desaturase (crtI, from Erwinia uredovora under constitutive 35S promoter control). This blend covers the necessities for beta-carotene union and, as trusted, yellow beta-carotene-bearing rice endosperm was acquired in the T0-age.

Genome-Edited Plants and the Challenges of Regulating Their Biosafety in Indonesia

<p>Genome editing is a precise breeding technique to improve plant properties by editing specific genes that regulate desired trait. Genome editing techniques can be designed so that the resulting plant does not contain foreign genes and the resulting changes in DNA sequences cannot be distinguished from products obtained by conventional gene mutations which have been considered as safe and therefore unregulated. Thus, genome editing products in some countries are also not specifically regulated as GM products even though their assembly process uses recombinant DNA and genetic transformation. Brazil, like<br />Indonesia ratified the Cartagena Protocol, but it issued a special regulation that provides dispensation for several types of genome editing products and exempts them from regulations that apply to transgenic plants. The steps taken by other countries in regulating genome editing products can be taken into consideration in drafting regulations in Indonesia, in order to create a conducive environment that supports the use of this potential technology while at the same time provides assurance regarding its safety to human health and the environment. The purpose of this review was to provide information on<br />the development of genome editing technologies in plant breeding, analyze its risks compared to that of conventional breeding, and compare its biosafety regulation in various countries to provide some considerations for drafting regulations on the risk assessment of genome editing products in Indonesia, as a ratifying country of the Cartagena Protocol.</p>