Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities

Nausea and vomiting of pregnancy (NVP) is a common condition that affects up to 70% of pregnant women. Hyperemesis gravidarum (HG) is considered the serious form of NVP, which is reported in 0.3–10.8% of pregnant women. NVP has a relatively benign course, but HG can be linked with some poor maternal, fetal, and offspring outcomes. The exact causes of NVP and HG are unknown, but various factors have been hypothesized to be associated with pathogenesis. With the advance of precision medicine and molecular biology, some genetic factors such as growth/differentiation factor 15 (GDF15) have become therapeutic targets. In our review, we summarize the historical hypotheses of the pathogenesis of NVP and HG including hormonal factors, Helicobacter pylori, gastrointestinal dysmotility, placenta-related factors, psychosocial factors, and new factors identified by genetics. We also highlight some approaches to the management of NVP and HG, including pharmacological treatment, complementary treatment, and some supporting treatments. Looking to the future, progress in understanding NVP and HG may reduce the adverse outcomes and improve the maternal quality of life during pregnancy.

Queens, but not their stored sperm, are resilient to temperature stress

Abiotic stressors such as extreme temperatures can reduce stored sperm viability within queen honey bees. However, little is known about how thermal stress may directly impact queen performance or other maternal quality metrics, such as queen mass, egg laying rate, and development of embryos within eggs. Here, in a blind field trial, we recorded laying pattern, queen mass, and average callow worker mass before and after exposing queens to a cold temperature (4°C, 2 h), hot temperature (42°C, 2 h), and hive temperature (33°C) to serve as a handling control. We then used proteomics to investigate potential vertical effects of maternal temperature stress on embryos, as well as to measure the abundance of previously determined protein markers for temperature stress in the spermathecal fluid. We found no significant effect of abiotic stress on any of the metrics we recorded. These data suggest that there are likely no lasting maternal effects of temperature stress on honey bee queens, and that the queens themselves are highly stress tolerant, but not their stored sperm.

DOES BREASTFEEDING OR NOT AFFECT A BETTER MATERNAL QUALITY OF LIFE? : LITERATURE REVIEW

Quality of life is important to achieve the best performance of mothers. Maternal quality of life is usually measured by WHOQOL-BREF standards (quality of life of the World Health Organization-BREF), SF-36 (Short-36), or MGI (Mother Generated Index). One factor that affects the maternal quality of life is breastfeeding. The practice of breastfeeding is the mother who is breastfeeding (giving only breast milk) and the mother who is not breastfeeding (with formula milk) as well as seeing the length of breastfeeding time for less than 6 months or more than 6 months. This literature review has research question with PICO standard to get the aim about the correlation between the practice of breastfeeding and maternal quality of life. 466 literatures were obtained from the SCOPUS, Proquest, Google Scholar, PubMed and EBSCOhost databases. Literature screening is done by looking at the inclusion and exclusion criteria that have been set so that 10 literatures will be reviewed. Most of the literature reports that mothers who breastfeed and continue to breastfeed even though only a month has a better quality of life than mothers who did not breastfeed. One study said that breastfeeding causes a decrease in the maternal quality of life, as well as several other studies that found no significant correlation between breastfeeding practices and maternal quality of life. This result can be used as a reference for the health policy to promote breastfeeding and quality of life.

Egg spottiness reflects female condition, physiological stress, and ornament expression in a common rallid species

Lay Summary • There is equivocal support for direct associations between maternal quality and deposition of protoporphyrin pigmentation (dark spots and blotches) in avian eggshells. • Research on protoporphyrin eggshell pigmentation has primarily focused on a single avian order (Passeriformes). • We examined associations of protoporphyrin-based eggshell pigmentation with female phenotypic and genetic traits in a non-passerine species, the Eurasian Coot. • Deposition of protoporphyrin in eggshells (total number per area of egg spots) positively correlated with female condition and expression of a putative bare-part ornament (frontal shield), while it was negatively associated with the level of physiological stress. • Protoporphyrin-based eggshell pigmentation acts as a reliable signal of female phenotypic (but not genetic) traits in the Eurasian Coot. • Signaling properties of protoporphyrin-based egg coloration are likely to largely differ between different evolutionary lineages of birds.

The reconstruction of Maternal Audit with the electronic health information System

the maternal audit Program that took place since 2012 as the development of quality improvement efforts and safety of maternal health services is still not by Hope. The maternal audit process itself is lengthy so that there can be certain time gaps in problem-solving, the possibility of changing the contents of the clinic's audit and a verbal autopsy is inaccurate. This research is expected to answer questions and provide solutions for the lack of functioning of the maternal audit in reducing maternal mortality, and generate a comprehensive policy in the effort to reduce maternal mortality by auditing Maternal quality.