scholarly journals Emerging Progress in Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Challenges and Opportunities

2022 ◽  
Vol 8 ◽  
Author(s):  
Chuan Liu ◽  
Guo Zhao ◽  
Danni Qiao ◽  
Lintao Wang ◽  
Yeling He ◽  
...  

Nausea and vomiting of pregnancy (NVP) is a common condition that affects up to 70% of pregnant women. Hyperemesis gravidarum (HG) is considered the serious form of NVP, which is reported in 0.3–10.8% of pregnant women. NVP has a relatively benign course, but HG can be linked with some poor maternal, fetal, and offspring outcomes. The exact causes of NVP and HG are unknown, but various factors have been hypothesized to be associated with pathogenesis. With the advance of precision medicine and molecular biology, some genetic factors such as growth/differentiation factor 15 (GDF15) have become therapeutic targets. In our review, we summarize the historical hypotheses of the pathogenesis of NVP and HG including hormonal factors, Helicobacter pylori, gastrointestinal dysmotility, placenta-related factors, psychosocial factors, and new factors identified by genetics. We also highlight some approaches to the management of NVP and HG, including pharmacological treatment, complementary treatment, and some supporting treatments. Looking to the future, progress in understanding NVP and HG may reduce the adverse outcomes and improve the maternal quality of life during pregnancy.

2021 ◽  
Author(s):  
Melissa Santos Nassif ◽  
Isabelle Cristinne Pinto Costa ◽  
Caroline de Castro Moura ◽  
Patrícia Mônica Ribeiro

Abstract BackgroundThe stages of pregnancy are accompanied by several biopsychosocial changes, among them are nausea and vomiting, which are often associated with negative feelings, in addition to generating physical impacts and impacts on the maternal quality of life. In this scenario, the Integrative and Complementary Practices (ICPs) are inserted as a potential treatment to control nausea and vomiting in this public. This review aims to synthesize the available evidence in the literature on the effects of integrative and complementary practices in the treatment of nausea and vomiting in pregnant women. MethodThe review will include only randomized controlled trials (RCTs) that examine the effects of ICPs versus placebo, routine treatment, or pharmacological intervention for the control of nausea and vomiting in healthy pregnant women. The outcomes of interest are those related to nausea and vomiting and possible adverse effects of the intervention. A search for studies will be carried out in the following databases: MEDLINE via PubMed, EMBASE, CINAHL, CENTRAL, ICTRP, LILACS, CUMED, IBECS, Web of Science, Scopus, CNKI, the World Health Organization’s International Clinical Trials Registry Platform (ICTRP) and ReBEC until July 31, 2021. There will be no restrictions on the publication year or language of the manuscripts. The texts will be evaluated in their entirety, after which they will be selected, the data of interest will be extracted, and the risk of bias and quality of evidence will be evaluated. The entire selection process will be carried out by two independent reviewers and a third reviewer will be available in case of disagreement. In the event that a meta-analysis can be conducted, it will evaluate interventions for the absolute difference between averages and potential heterogeneity. If the data are deemed inadequate for a meta-analysis, a systematic narrative synthesis will be carried out. This protocol was proposed based on the preferred reporting item guidelines for systematic review and meta-analysis protocols (PRISMA-P). DiscussionThe results of this systematic review will robustly fill this knowledge gap and possibly assist in evidence-based practices provided for pregnant women experiencing nausea and vomiting.Systematic review registration: PROSPERO CRD42020221570


Author(s):  
Pramukti Dian Setianingrum ◽  
Farah Irmania Tsani

Backgroud: The World Health Organization (WHO) explained that the number of Hyperemesis Gravidarum cases reached 12.5% of the total number of pregnancies in the world and the results of the Demographic Survey conducted in 2007, stated that 26% of women with live births experienced complications. The results of the observations conducted at the Midwife Supriyati Clinic found that pregnant women with hyperemesis gravidarum, with a comparison of 10 pregnant women who examined their contents there were about 4 pregnant women who complained of excessive nausea and vomiting. Objective: to determine the hyperemesis Gravidarum of pregnant mother in clinic. Methods: This study used Qualitative research methods by using a case study approach (Case Study.) Result: The description of excessive nausea of vomiting in women with Hipermemsis Gravidarum is continuous nausea and vomiting more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the body weight decreases and interferes with daily activities days The factors that influence the occurrence of Hyperemesis Gravidarum are Hormonal, Diet, Unwanted Pregnancy, and psychology, primigravida does not affect the occurrence of Hyperemesis Gravidarum. Conclusion: Mothers who experience Hyperemesis Gravidarum feel nausea vomiting continuously more than 10 times in one day, no appetite or vomiting when fed, the body feels weak, blood pressure decreases until the weight decreases and interferes with daily activities, it is because there are several factors, namely, hormonal actors, diet, unwanted pregnancy, and psychology.


2013 ◽  
Vol 23 (3) ◽  
pp. 1019-1026 ◽  
Author(s):  
Christina Stern ◽  
Eva-Maria Trapp ◽  
Eva Mautner ◽  
Maria Deutsch ◽  
Uwe Lang ◽  
...  

2019 ◽  
Vol 1 (1) ◽  
pp. 36-44
Author(s):  
Ani Nurdiana ◽  
Betty Mangkuji ◽  
Rismahara Lubis

Pregnancy causes a lot of change in the mother’s body, so there are various kinds of physiological discomfort in the mother such as nause and vomiting, usually mild and controlable. This condition sometimes stops in the first trimester, but its effect may lead to nutritional disorder, dehydration, weakness, weight loss, and electrolyte imbalances. If not treated, it will worsen into Hyperemesis Gravidarum This study aimed to determine the effectiveness og ginger candy in reducing the frecuency of nause and vomiting in first trimester pregnant women in the Khairunida clinik with experimental Quasy design and tested by One Group Pretest Postest. About 15 samples were obtained through purposive sampling technique and the data were taken using the T-dependent test. Through the study, it was found that the frequency of nausea and vomiting before being given intervation was 10,93 and after being given intervation was 3,33 with an average decrease by 7,60. Through the statistical test, it was obtained the p value <(0.05) so that this study concluded that administration of ginger candy was effective in reduring nausea and vomiting in first trimester pregnant women. Further researchers are expected toreduce the use of non-pharmacological drugs to overcome nausea and vomiting in first trimester pregnant women and collaborate with the pharmacy department to facilitate the process of making good qualityy ginger candy.


e-CliniC ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jessica F. Rorrong ◽  
John J. E. Wantania ◽  
Anastasi M. Lumentut

Abstract: Nausea and vomiting are common problems in early pregnancy. Symptoms of nausea and vomiting in pregnant women that persist and get worse are called hyperemesis gravidarum. The causes of hyperemesis gravidarum are not exactly known, but it is supposed that they could be caused inter alia by psychological factors. This study was aimed to determine the relationship between the psychological state of pregnant women and the incidence of hyperemesis gravidarum. This was a literature review study by using three databases, namely Google Scholar, ClinicalKey, and Pubmed. The keywords used were psychological AND hyperemesis gravidarum. The result showed that the psychological conditions assessed in most literatures were anxiety disorders, depression, and stress. Pregnant women who suffered from anxiety and stress could trigger or worsen the depression. The higher level of anxiety would increase the chance of suffering from hyperemesis gravidarum. Therefore, pregnant women need additional psychological support during treatment and as a follow-up for pregnant women with hyperemesis gravidarum. In conclusion, the psychological state of pregnant women is related to the incidence of hyperemesis gravidarum.Keywords: psychological, hyperemesis gravidarum, nausea and vomiting Abstrak: Mual dan muntah merupakan masalah yang biasa terjadi pada awal kehamilan. Gejala mual dan muntah pada ibu hamil yang menetap dan bahkan bertambah berat disebut hiperemesis gravidarum. Faktor pemicu terjadinya hiperemesis gravidarum pada ibu hamil belum diketahui secara pasti, tetapi diperkirakan antara lain oleh faktor psikologis. Penelitian ini bertujuan untuk mengetahui hubungan keadaan psikologis ibu hamil dengan kejadian hiperemesis gravidarum. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu Google Scholar, ClinicalKey, dan Pubmed. Kata kunci yang digunakan yaitu psikologis /psychological AND hiperemesis gravidarum/hyperemesis gravidarum. Hasil penelitian mendapatkan bahwa kondisi psikologis yang dinilai pada sebagian besar literatur yang dikaji ialah mengenai gangguan kecemasan, depresi, dan stres. Ibu hamil yang mengalami cemas dan stres dapat memicu atau memperburuk terjadinya depresi. Tingkat kecemasan yang semakin tinggi akan meningkatkan peluang untuk mengalami hiperemesis gravidarum sehingga diperlukan dukungan psikologis tambahan selama perawatan dan sebagai tindak lanjut ibu hamil dengan hiperemesis gravidarum. Simpulan penelitian ini ialah keadaan psikologis ibu hamil berhubungan dengan kejadian hiperemesis gravidarum. Kata kunci: psikologis, hiperemesis gravidarum, mual dan muntah


2018 ◽  
Vol 39 (01) ◽  
pp. 029-035 ◽  
Author(s):  
Michael Schatz ◽  
Jennifer Namazy

AbstractPregnancy may be complicated by new onset or preexisting asthma. This article reviews diagnosis and management of asthma in the pregnant patient. Special attention is paid to the challenges in diagnosis and management of this condition during pregnancy. Asthma is one of the most common potentially serious medical problems to complicate pregnancy, and asthma may adversely affect both maternal quality of life and perinatal outcomes. Asthma may adversely affect both maternal quality of life and, perinatal outcomes. Pregnant asthmatics have been shown to be at an increased risk of adverse perinatal outcomes. Optimal management of asthma during pregnancy is thus important for both mother and baby. This article provides an update on the available literature regarding the safety of commonly used asthma medications during pregnancy.


Clinics ◽  
2009 ◽  
Vol 64 (8) ◽  
pp. 751-756 ◽  
Author(s):  
Carlos Zubaran ◽  
Katia Foresti ◽  
Marina Verdi Schumacher ◽  
Mariana Rossi Thorell ◽  
Lucia Cristina Muller ◽  
...  

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