Personalizing Medication Recommendation with a Graph-Based Approach

The broad adoption of electronic health records (EHRs) has led to vast amounts of data being accumulated on a patient’s history, diagnosis, prescriptions, and lab tests. Advances in recommender technologies have the potential to utilize this information to help doctors personalize the prescribed medications. However, existing medication recommendation systems have yet to make use of all these information sources in a seamless manner, and they do not provide a justification on why a particular medication is recommended. In this work, we design a two-stage personalized medication recommender system called PREMIER that incorporates information from the EHR. We utilize the various weights in the system to compute the contributions from the information sources for the recommended medications. Our system models the drug interaction from an external drug database and the drug co-occurrence from the EHR as graphs. Experiment results on MIMIC-III and a proprietary outpatient dataset show that PREMIER outperforms state-of-the-art medication recommendation systems while achieving the best tradeoff between accuracy and drug-drug interaction. Case studies demonstrate that the justifications provided by PREMIER are appropriate and aligned to clinical practices.

PNTRS

A news recommendation system not only must recommend the latest, trending and personalized news to the users but also give opportunity to know about the people’s opinion on trending news. Most of the existing news recommendation systems focus on recommending news articles based on user-specific tweets. In contrast to these recommendation systems, the proposed Personalized News and Tweet Recommendation System (PNTRS) recommends tweets based on the recommended article. It firstly generates news recommendation based on user’s interest and twitter profile using the Multinomial Naïve Bayes (MNB) classifier. Further, the system uses these recommended articles to recommend various trending tweets using fuzzy inference system. Additionally, feedback-based learning is applied to improve the efficiency of the proposed recommendation system. The user feedback rating is taken to evaluate the satisfaction level and it is 7.9 on the scale of 10.

The Simpson’s Paradox in the Offline Evaluation of Recommendation Systems

Recommendation systems are often evaluated based on user’s interactions that were collected from an existing, already deployed recommendation system. In this situation, users only provide feedback on the exposed items and they may not leave feedback on other items since they have not been exposed to them by the deployed system. As a result, the collected feedback dataset that is used to evaluate a new model is influenced by the deployed system, as a form of closed loop feedback. In this article, we show that the typical offline evaluation of recommender systems suffers from the so-called Simpson’s paradox. Simpson’s paradox is the name given to a phenomenon observed when a significant trend appears in several different sub-populations of observational data but disappears or is even reversed when these sub-populations are combined together. Our in-depth experiments based on stratified sampling reveal that a very small minority of items that are frequently exposed by the deployed system plays a confounding factor in the offline evaluation of recommendation systems. In addition, we propose a novel evaluation methodology that takes into account the confounder, i.e., the deployed system’s characteristics. Using the relative comparison of many recommendation models as in the typical offline evaluation of recommender systems, and based on the Kendall rank correlation coefficient, we show that our proposed evaluation methodology exhibits statistically significant improvements of 14% and 40% on the examined open loop datasets (Yahoo! and Coat), respectively, in reflecting the true ranking of systems with an open loop (randomised) evaluation in comparison to the standard evaluation.

BitterMatch: Recommendation systems for matching molecules with bitter taste receptors

Bitterness is an aversive cue elicited by thousands of chemically diverse compounds. Bitter taste may prevent consumption of foods and jeopardize drug compliance. The G protein-coupled receptors for bitter taste, TAS2Rs, have species-dependent number of subtypes and varying expression levels in extraoral tissues. Molecular recognition by TAS2R subtypes is physiologically important, and presents a challenging case study for ligand-receptor matchmaking. Inspired by hybrid recommendation systems, we developed a new set of similarity features, and created the BitterMatch algorithm that predicts associations of ligands to receptors with ~80% precision at ~50% recall. Associations for several compounds were tested in-vitro, resulting in 80% precision and 42% recall. The encouraging performance was achieved by including receptor properties and integrating experimentally determined ligand-receptor associations with chemical ligand-to-ligand similarities. BitterMatch can predict off-targets for bitter drugs, identify novel ligands and guide flavor design. Inclusion of neighbor-informed similarities improves as experimental data mounts, and provides a generalizable framework for molecule-biotarget matching.

Multipointer Coattention Recommendation with Gated Neural Fusion between ID Embedding and Reviews

Recently, the interaction information from reviews has been modeled to acquire representations between users and items and improve the sparsity problem in recommendation systems. Reviews are more responsive to information about users’ preferences for the different aspects and attributes of items. However, how to better construct the representation of users (items) still needs further research. Inspired by the interaction information from reviews, auxiliary ID embedding information is used to further enrich the word-level representation in the proposed model named MPCAR. In this paper, first, a multipointer learning scheme is adopted to extract the most informative reviews from user and item reviews and represent users (items) in a word-by-word manner. Then, users and items are embedded to extract the ID embedding that can reveal the identity of users (items). Finally, the review features and ID embedding are input to the gated neural network for effective fusion to obtain richer representations of users and items. We randomly select ten subcategory datasets from the Amazon dataset to evaluate our algorithm. The experimental results show that our algorithm can achieve the best results compared to other recommendation approaches.

A review of a recommendation filtering system approach based on reliable sustainable opinion mining

PurposeIn this article the authors will focus on the state of the art on information filtering and recommender systems based on trust. Then the authors will represent a variety of filtering and recommendation techniques studied in different literature, like basic content filtering, collaborative filtering and hybrid filtering. The authors will also examine different trust-based recommendation algorithms. It will ends with a summary of the different existing approaches and it develops the link between trust, sustainability and recommender systems.Design/methodology/approachMethodology of this study will begin with a general introduction to the different approaches of recommendation systems; then define trust and its relationship with recommender systems. At the end the authors will present their approach to “trust-based recommendation systems”.FindingsThe purpose of this study is to understand how groups of users could improve trust in a recommendation system. The authors will examine how to evaluate the performance of recommender systems to ensure their ability to meet the needs that led to its creation and to make the system sustainable with respect to the information. The authors know very well that selecting a measure must depend on the type of data to be processed and user interests. Since the recommendation domain is derived from information search paradigms, it is obvious to use the evaluation measures of information systems.Originality/valueThe authors presented a list of recommendations systems. They examined and compared several recommendation approaches. The authors then analyzed the dominance of collaborative filtering in the field and the emergence of Recommender Systems in social web. Then the authors presented and analyzed different trust algorithms. Finally, their proposal was to measure the impact of trust in recommendation systems.

A Survey of Recommendation Systems: Recommendation Models, Techniques, and Application Fields

This paper reviews the research trends that link the advanced technical aspects of recommendation systems that are used in various service areas and the business aspects of these services. First, for a reliable analysis of recommendation models for recommendation systems, data mining technology, and related research by application service, more than 135 top-ranking articles and top-tier conferences published in Google Scholar between 2010 and 2021 were collected and reviewed. Based on this, studies on recommendation system models and the technology used in recommendation systems were systematized, and research trends by year were analyzed. In addition, the application service fields where recommendation systems were used were classified, and research on the recommendation system model and recommendation technique used in each field was analyzed. Furthermore, vast amounts of application service-related data used by recommendation systems were collected from 2010 to 2021 without taking the journal ranking into consideration and reviewed along with various recommendation system studies, as well as applied service field industry data. As a result of this study, it was found that the flow and quantitative growth of various detailed studies of recommendation systems interact with the business growth of the actual applied service field. While providing a comprehensive summary of recommendation systems, this study provides insight to many researchers interested in recommendation systems through the analysis of its various technologies and trends in the service field to which recommendation systems are applied.