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The starting of DDT production during World War II signalized also the beginning of very rapid increase in pesticide use. Pesticides applied in the control of invertebrates are insecticides. On the other site, vertebrates are controlled by rodenticides killing rodents, avicides are applying to repel birds and piscicides are used in fish control. Herbicides are most important in agriculture by plants cultivation,fungicides are useful in killing fungi, bactericides are used against bacteria, slimicides against slime- cusing organisms in water and algicides against algae. Many pesticides which were used in agriculture last 30-40 years ago are no longer authorised and have been replaced by pesticides on non-chemical basis. Currently, the aim of the REACH Regulation in European Union is to provide better protection for humans and the environment from possible chemical risks and to promote sustainable development. The European Chemicals Agency established under this regulation and based in Helsinki, is responsible for managing the technical, scientific and administrative aspects of REACH, and for ensuring consistency in its application (www.europarl.europa.eu). In order to enhance the level of protection of human health and the environment, the same criteria for identifying, and labels for describing, chemical hazards should be used throughout the EU and the world (www.europarl.europa.eu). This contribution briefly refers about the pesticides classification and their most commonly used detoxification.