Identification of Plasmodium secreted proteins based on monoDiKGap and distance-based Top-n-gram methods

Background: Many malaria infections are caused by Plasmodium falciparum. Accurate classification of the proteins secreted by the malaria parasite, which are essential for the development of anti-malarial drugs, is essential. Objective: To accurately classify the proteins secreted by the malaria parasite. Methods: Therefore, in order to improve the accuracy of the prediction of plasmodium secreted proteins, we established a classification model MGAP-SGD. MonodikGap features (k=7) of the secreted proteins were extracted, and then the optimal features were selected by the AdaBoost method. Finally, based on the optimal set of secreted proteins, the model was used to predict the secreted proteins using the stochastic gradient descent (SGD) algorithm. Results: Our model uses a 10-fold cross-validation set and independent test set in the stochastic gradient descent (SGD) classifier to validate the model, and the accuracy rates are 98.5859% and 97.973%, respectively. Conclusion: This also fully proves that the effectiveness and robustness of the prediction results of the MGAP-SGD model can meet the prediction needs of the secreted proteins of plasmodium.

A deep learning approach based on stochastic gradient descent and least absolute shrinkage and selection operator for identifying diabetic retinopathy

More than eighty-five to ninety percentage of the diabetic patients are affected with diabetic retinopathy (DR) which is an eye disorder that leads to blindness. The computational techniques can support to detect the DR by using the retinal images. However, it is hard to measure the DR with the raw retinal image. This paper proposes an effective method for identification of DR from the retinal images. In this research work, initially the Weiner filter is used for preprocessing the raw retinal image. Then the preprocessed image is segmented using fuzzy c-mean technique. Then from the segmented image, the features are extracted using grey level co-occurrence matrix (GLCM). After extracting the fundus image, the feature selection is performed stochastic gradient descent, and least absolute shrinkage and selection operator (LASSO) for accurate identification during the classification process. Then the inception v3-convolutional neural network (IV3-CNN) model is used in the classification process to classify the image as DR image or non-DR image. By applying the proposed method, the classification performance of IV3-CNN model in identifying DR is studied. Using the proposed method, the DR is identified with the accuracy of about 95%, and the processed retinal image is identified as mild DR.

A Computational Intelligence Approach for Predicting Medical Insurance Cost

In the domains of computational and applied mathematics, soft computing, fuzzy logic, and machine learning (ML) are well-known research areas. ML is one of the computational intelligence aspects that may address diverse difficulties in a wide range of applications and systems when it comes to exploitation of historical data. Predicting medical insurance costs using ML approaches is still a problem in the healthcare industry that requires investigation and improvement. Using a series of machine learning algorithms, this study provides a computational intelligence approach for predicting healthcare insurance costs. The proposed research approach uses Linear Regression, Support Vector Regression, Ridge Regressor, Stochastic Gradient Boosting, XGBoost, Decision Tree, Random Forest Regressor, Multiple Linear Regression, and k-Nearest Neighbors A medical insurance cost dataset is acquired from the KAGGLE repository for this purpose, and machine learning methods are used to show how different regression models can forecast insurance costs and to compare the models’ accuracy. The results shows that the Stochastic Gradient Boosting (SGB) model outperforms the others with a cross-validation value of 0.0.858 and RMSE value of 0.340 and gives 86% accuracy.

Kinerja Algoritma Optimasi Root-Mean-Square Propagation dan Stochastic Gradient Descent pada Klasifikasi Pneumonia Covid-19 Menggunakan CNN

Penelitian ini berkaitan dengan proses klasifikasi Pneumonia Covid-19 (radang paru-paru atau pneumonia yang disebabkan oleh virus corona SARS-CoV-2) dari citra hasil foto rontgen / x-ray paru-paru dengan menggunakan pendekatan pembelajaran mesin. Klasifikasi dilakukan untuk menentukan apakah kondisi paru-paru seseorang mengalami Pneumonia Covid-19, Pneumonia biasa, atau Normal / Sehat. Untuk menghasilkan kinerja klasifikasi yang lebih baik, proses optimasi seringkali digunakan pada tahap pelatihan data. Banyak teknik yang digunakan untuk melakukan optimasi tersebut, diantaranya adalah algoritma Root-Mean-Square Propagation (RMSprop) dan Stochastic Gradient Descent (SGD). Pada penelitian ini, pengujian dilakukan terhadap kedua metode tersebut untuk mengetahui kinerjanya pada klasifikasi Pneumonia Covid-19. Metode klasifikasi menggunakan Convolutional Neural Network (CNN) yang menerapkan 5 layer konvolusi dengan nilai filter 16, 32, 64, 128, dan 256. Proses pelatihan menggunakan 3.900 citra yang terdiri atas 1.300 citra pneumonia covid-19, 1.300 citra pneumonia, dan 1.300 citra normal. Sedangkan proses validasi menggunakan 450 citra dan proses pengujian mengunakan 225 citra. Berdasarkan uji coba yang telah dilakukan, implementasi algoritma optimasi RMSprop menghasilkan akurasi 87,99%, presisi 0,88, recall 0,86, dan f1 score 0,87. Sedangkan implementasi algoritma optimasi SGD menghasilkan akurasi 66,22%, presisi 0,69, recall 0,64, dan f1 score 0,67. Hasil ini memberikan informasi penting bahwa algoritma optimasi RMSprop menghasilkan kinerja yang jauh lebih baik daripada SGD pada klasifikasi Pneumonia Covid-19.

Entropic gradient descent algorithms and wide flat minima*

The properties of flat minima in the empirical risk landscape of neural networks have been debated for some time. Increasing evidence suggests they possess better generalization capabilities with respect to sharp ones. In this work we first discuss the relationship between alternative measures of flatness: the local entropy, which is useful for analysis and algorithm development, and the local energy, which is easier to compute and was shown empirically in extensive tests on state-of-the-art networks to be the best predictor of generalization capabilities. We show semi-analytically in simple controlled scenarios that these two measures correlate strongly with each other and with generalization. Then, we extend the analysis to the deep learning scenario by extensive numerical validations. We study two algorithms, entropy-stochastic gradient descent and replicated-stochastic gradient descent, that explicitly include the local entropy in the optimization objective. We devise a training schedule by which we consistently find flatter minima (using both flatness measures), and improve the generalization error for common architectures (e.g. ResNet, EfficientNet).