The second part of the article continues the analytical and historiographical overview of the problems that are substantively related to the question of the role, meaning and historical fate of metaphysics. The author focuses on the phenomenon of the return of metaphysics to the philosophy of our time. The author traces the gradual rehabilitation of metaphysical problems in post-positivist studies of sci-ence. An attempt is made to differentiate these studies from the viewpoint of the opposition between internalism and externalism. The author shows the limits of this differentia-tion and highlights the mixed type of re-search, which focuses on the interaction of “external” and “internal” determinants of knowledge. It is shown that the postpositivist idea of the background knowledge extends not only to scientific (empirical) knowledge, but also to its philosophical (theoretical) justification, which is recognized by many re-searchers as historically and culturally conditioned. This opens up the possibility of a historical critique of the ontological presuppositions of the epistemological (transcendental) justification of science. Such presuppositions are considered in relation to the dis-course of negative ontology, which prohibits the cognitive experience of transcendent be-ing. The author shows that the criticism of these assumptions is carried out in the form of a regressive transcendental argument, which, comparing them with a new, philo-sophically revised scientific ontology, reveals their historically limited character. Thus, the regressive transcendental argument allows us to go beyond the negative ontology of the transcendental justification of science. This leads to the replacement of historical epistemology, whose subject matter is limited to knowledge and its historically mobile structures, with historical ontology, which returns to the description and explanation of reality. The author considers the concepts of new re-alism in the context of historical ontology and traces the connection of the new realism with the post-metaphysical and metametaphysical discourses.