Acoustofluidic localization of sparse particles on a piezoelectric resonant sensor for nanogram-scale mass measurements

The ability to weigh microsubstances present in low concentrations is an important tool for environmental monitoring and chemical analysis. For instance, developing a rapid analysis platform that identifies the material type of microplastics in seawater would help evaluate the potential toxicity to marine organisms. In this study, we demonstrate the integration of two different techniques that bring together the functions of sparse particle localization and miniaturized mass sensing on a microelectromechanical system (MEMS) chip for enhanced detection and minimization of negative measurements. The droplet sample for analysis is loaded onto the MEMS chip containing a resonant mass sensor. Through the coupling of a surface acoustic wave (SAW) from a SAW transducer into the chip, the initially dispersed microparticles in the droplet are localized over the detection area of the MEMS sensor, which is only 200 µm wide. The accreted mass of the particles is then calibrated against the resulting shift in resonant frequency of the sensor. The SAW device and MEMS chip are detachable after use, allowing the reuse of the SAW device part of the setup instead of the disposal of both parts. Our platform maintains the strengths of noncontact and label-free dual-chip acoustofluidic devices, demonstrating for the first time an integrated microparticle manipulation and real-time mass measurement platform useful for the analysis of sparse microsubstances.

Optical-Thermally Excited Graphene Resonant Mass Detection: A Molecular Dynamics Analysis

In consideration of the presented optical-thermally excited resonant mass detection scheme, molecular dynamics calculations are performed to investigate the thermal actuation and resonant mass sensing mechanism. The simulation results indicate that an extremely high temperature exists in a 6% central area of the graphene sheet exposed to the exciting laser. Therefore, constraining the laser driving power and enlarging the laser spot radius are essential to weaken the overheating in the middle of the graphene sheet, thus avoiding being burned through. Moreover, molecular dynamics calculations demonstrate a mass sensitivity of 214 kHz/zg for the graphene resonator with a pre-stress of 1 GPa. However, the adsorbed mass would degrade the resonant quality factor from 236 to 193. In comparison, the sensitivity and quality factor could rise by 1.3 and 4 times, respectively, for the graphene sheet with a pre-stress of 5 GPa, thus revealing the availability of enlarging pre-stress for better mass sensing performance.

An Extensive Review of Nanotubes Based Mass-Sensors

Sensors have tremendous demand in Industry because of their properties like sensitiveness, responsiveness, stability, selectiveness, and cost-effectiveness. Therefore, it is a dire need to develop advanced sensing materials and technologies. With the rapid advancement in micro and nanotechnologies in Micro-electromechanical Systems/ Nano-electromechanical Systems (MEMS/NEMS), more emphasis has to develop micro and nanomechanical resonators, having great interest for engineering fields. When MEMS/NEMS resonators are used for advancement in sensors, then they could perform both detection and sensing. Both BNNT and CNT are the strongest lightweight nanomaterials used for mass sensing applications. BNNT contradict to CNT have nontoxic property towards health and environment because of its structural stability and chemical inertness, which makes it more suitable for biological applications. From various studies, the conclusion comes out that the non-linear dynamic behavior of Boron Nitride Nanotubes-based mass sensors has not yet been explored. It is required strongly to study the non-linear conduct of BNNT for designing a better performing mass sensor.

Nanomechanical Molecular Mass Sensing Using Suspended Microchannel Resonators

In this work we study the different phenomena taking place when a hydrostatic pressure is applied in the inner fluid of a suspended microchannel resonator. Additionally to pressure-induced stiffness terms, we have theoretically predicted and experimentally demonstrated that the pressure also induces mass effects which depend on both the applied pressure and the fluid properties. We have used these phenomena to characterize the frequency response of the device as a function of the fluid compressibility and molecular masses of different fluids ranging from liquids to gases. The proposed device in this work can measure the mass density of an unknown liquid sample with a resolution of 0.7 µg/mL and perform gas mixtures characterization by measuring its average molecular mass with a resolution of 0.01 atomic mass units.