Substantiation of criteria of professional suitability in patients with polyneuropathies of the upper limbs from functional overvoltage

Occupational polyneuropathy of the upper extremities from the effects of physical overload in the Russian Federation is a common occupational disease that leads to a long-term decrease in the occupational capacity of patients. But at the same time, the current regulatory documents do not contain any detailed recommendations for the examination of professional suitability in patients with this disease. The aim of the study is to substantiate the ways of improving expert approaches to determining the professional suitability of patients with occupational polyneuropathy caused by physical overload. The adequacy of two alternative approaches to assessing the professional suitability of patients with occupational polyneuropathy was assessed, the first of which allowed the patients to continue working under the influence of physical overload, and the second indicated the need to employ these patients at work without the influence of physical overload. The adequacy of labor recommendations was assessed by the dynamics of the health status of workers in different employment options. According to the dynamic observation of a group of 412 patients with occupational polyneuropathy, it was found that when they continued to work under conditions of physical overload, an unfavorable course of occupational pathology in the form of progression of polyneuropathy was regularly noted (36,1%), less often the development of new occupational diseases of the musculoskeletal system from physical overload. Among patients employed at work without physical overload, cases of progression of occupational pathology were not observed. Among patients with occupational polyneuropathy, in the majority (61.9%) this disease was combined with occupational pathology of the musculoskeletal system, occupational radiculopathies of the cervical and lumbosacral levels. Periodic exacerbations of these diseases can also lead to the need to establish contraindications for admission to physically demanding work. During dynamic observation of patients with occupational polyneuropathy in 39.5% of patients, due to the unfavorable course of cardiovascular diseases, there were grounds for determining contraindications to work under the influence of all harmful industrial factors. As a justification for contraindications to continue working under conditions of physical overload and other harmful production factors (general and local vibration, general hypothermia), the probability of progression of an occupational disease should be considered. When choosing the types of work, one should consider the presence of concomitant occupational and general diseases.

Automatically Determining Lumbar Load during Physically Demanding Work: A Validation Study

A sensor-based system using inertial magnetic measurement units and surface electromyography is suitable for objectively and automatically monitoring the lumbar load during physically demanding work. The validity and usability of this system in the uncontrolled real-life working environment of physically active workers are still unknown. The objective of this study was to test the discriminant validity of an artificial neural network-based method for load assessment during actual work. Nine physically active workers performed work-related tasks while wearing the sensor system. The main measure representing lumbar load was the net moment around the L5/S1 intervertebral body, estimated using a method that was based on artificial neural network and perceived workload. The mean differences (MDs) were tested using a paired t-test. During heavy tasks, the net moment (MD = 64.3 ± 13.5%, p = 0.028) and the perceived workload (MD = 5.1 ± 2.1, p < 0.001) observed were significantly higher than during the light tasks. The lumbar load had significantly higher variances during the dynamic tasks (MD = 33.5 ± 36.8%, p = 0.026) and the perceived workload was significantly higher (MD = 2.2 ± 1.5, p = 0.002) than during static tasks. It was concluded that the validity of this sensor-based system was supported because the differences in the lumbar load were consistent with the perceived intensity levels and character of the work tasks.

OP0086 THE DEGREE OF BONE MARROW EDEMA AS DETECTED BY MAGNETIC RESONANCE IMAGING IN THE SACROILIAC JOINTS AND THE SPINE SUSPICIOUS OF AXIAL SPONDYLOARTHRITIS IN THE GENERAL POPULATION IS ASSOCIATED WITH DIFFERENT FACTORS

Background:Taking advantage of a large population-based study we have recently reported that the frequency of bone marrow edema (BME) and fatty lesions (FL) in the sacroiliac joints (SIJ) and the spine of individuals <45 years detected by magnetic resonance imaging (MRI) suggestive of axial spondyloathritis (axSpA) is higher than expected.Objectives:To identify and compare factors associated with the extension of MRI lesions in the spine and the SIJ in the general population.Methods:All available spinal- (sagittal T1/T2 sequences) and SIJ- (semicoronal STIR sequences) MRIs were evaluated by two trained readers blinded to clinical data. BME (SIJ and spine) suggestive of axSpA were recorded. The extension of BME was quantified using the Berlin MRI score. Discrepancies were resolved by consensus. Degenerative lesions of the Modic type were excluded. The association of age (increase per decade), sex, HLA-B27 and hsCRP positivity, smoking (ever smoker vs. no smoker), spinal pain (yes vs. no in last 3 months), body mass index (BMI) categories (WHO definition), physically demanding job, and giving birth within the last 12 month with the severity of BME were examined. Associations between clinical factors and the Berlin MRI score were analyzed by negative binomial regression models resulting in incidence rate ratios (IRRs).Results:MRIs of 793 volunteers from the general population, mean age 37.3±6.3 years, 49.4% male, 8.9% HLA B27+, 7% CRP-positive, 56.9% with back pain in the last 3 months (28.8% with back pain NRS ≥4/10), 35.7% reported physically heavy work, 55% with BMI > 25 kg/m2, 16.2% current smokers, and 5% of females with pregnancy in the last year before MRI examination, were evaluated.For BME on SIJ-MRIs, significant associations (IRR, 95% confidence level) were found for pregnancy in the last year (3.82, 1.17-14.24), HLA-B27+ (2.42, 1.33-4.55), BMI (25-30 vs. <25; 2.09 (1.33-3.31)) and presence of back pain in the last 3 months (1.54, 1.02-2.33).For BME on spinal MRIs, significant associations were found for age per decade increase (1.45, 1.10-1.91) and physically demanding work (1.45, 1.04-2.00), while HLA-B27+ (1.32, 0.79-2.24), BMI (>30: 0.84, 0.53-1.32 (<25 reference)) and back pain in the last 3 months (1.29, 0.95-1.77) showed no association. Overall, spinal BME was more frequent than SIJ BME in the participants working at a desktop (61.5% vs. 54.4%), while smokers (66.9% vs. 63.8%) and participants with back pain in the last 3 months (62.5% vs. 56.9%) had more often SIJ BME than spinal BME, respectively.Conclusion:In this population-based study, individuals aged <45 years, HLA-B27+, women with pregnancy in the last year and presence of back pain were associated with the extent of BME in the SIJ, while age and physically demanding work were associated with the extent of BME in the spine. These data support the hypothesis of a mechanic origin of BME in the general population aged <45 years, while HLA B27 is a severity but not a susceptibility factor for BME in the SIJ.Acknowledgments:n/aDisclosure of Interests:Xenofon Baraliakos Grant/research support from: Grant/research support from: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Consultant of: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Speakers bureau: AbbVie, BMS, Celgene, Chugai, Merck, Novartis, Pfizer, UCB and Werfen, Adrian Richter: None declared, Daniel Feldmann: None declared, Anne Ott: None declared, Robin Buelow: None declared, Carsten Schmidt: None declared, Juergen Braun Grant/research support from: Abbvie (Abbott), Amgen, BMS, Boehringer, Celgene, Celltrion, Centocor, Chugai, Eli Lilly and Company, Medac, MSD (Schering Plough), Mundipharma, Novartis, Pfizer (Wyeth), Roche, Sanofi- Aventis, and UCB Pharma, Consultant of: Abbvie (Abbott), Amgen, BMS, Boehringer, Celgene, Celltrion, Centocor, Chugai, EBEWE Pharma, Eli Lilly and Company, Medac, MSD (Schering-Plough), Mundipharma, Novartis, Pfizer (Wyeth), Roche, Sanofi-Aventis, and UCB Pharma, Speakers bureau: Abbvie (Abbott), Amgen, BMS, Boehringer, Celgene, Celltrion, Centocor, Chugai, EBEWE Pharma, Eli Lilly and Company, Medac, MSD (Schering-Plough), Mundipharma, Novartis, Pfizer (Wyeth), Roche, Sanofi-Aventis, and UCB Pharma

Work-relatedness of inguinal hernia: a systematic review including meta-analysis and GRADE

Purpose Clinicians need to know whether inguinal hernia (IH) can be attributed to work to answer questions regarding prevention and medical causation. This review describes whether work-related risk factors are associated with IH. Methods A systematic review was performed in Medline via PubMed until February 3rd, 2020. Inclusion criteria were that IH was diagnosed by a clinician, and workers exposed to work-related risk factors were compared to workers less exposed or not at all. A quality assessment and a meta-analysis using Cochrane’s RevMan 5.3 were performed, including GRADE for quality of evidence. Results The search resulted in 540 references. Fourteen studies fulfilled the inclusion criteria, of which three were included in a meta-analysis, all three being of high quality, including 621 workers diagnosed with IH. The meta-analysis revealed significant associations with physically demanding work (OR 2.30, 95% CI 1.56–3.40). Two prospective studies, including 382 and 22,926 cases revealed associations that this was true for male workers with a lateral IH that reported standing or walking for more than six hours per workday (OR 1.45, 95% CI 1.12–1.88) or lifting cumulative loads of more than 4000 kg per workday (OR 1.32, 95% CI 1.27–1.38). The level of certainty for the latter two work-related risk factors was moderate and high according to GRADE. Conclusion Lateral IH among males is associated with work-related risk factors depending on the level of exposure to the time standing/walking per workday, or the amount of load lifted per workday.

A Systematic Review of Workplace Interventions to Rehabilitate Musculoskeletal Disorders Among Employees with Physical Demanding Work

Purpose This systematic review investigates the effectiveness of workplace interventions to rehabilitate musculoskeletal disorders (MSDs) among employees with physically demanding work. Methods A systematic search was conducted in bibliographic databases including PubMed and Web of Science Core Collection for English articles published from 1998 to 2018. The PICO strategy guided the assessment of study relevance and the bibliographical search for randomized controlled trials (RCTs) and non-RCTs in which (1) participants were adult workers with physically demanding work and MSD (including specific and non-specific MSD and musculoskeletal pain, symptoms, and discomfort), (2) interventions were initiated and/or carried out at the workplace, (3) a comparison group was included, and (4) a measure of MSD was reported (including musculoskeletal pain, symptoms, prevalence or discomfort). The quality assessment and evidence synthesis adhered to the guidelines developed by the Institute for Work & Health (Toronto, Canada) focusing on developing practical recommendations for stakeholders. Relevant stakeholders were engaged in the review process. Results Level of evidence from 54 high and medium quality studies showed moderate evidence of a positive effect of physical exercise. Within this domain, there was strong evidence of a positive effect of workplace strength training. There was limited evidence for ergonomics and strong evidence for no benefit of participatory ergonomics, multifaceted interventions, and stress management. No intervention domains were associated with “negative effects”. Conclusions The evidence synthesis recommends that implementing strength training at the workplace can reduce MSD among workers with physically demanding work. In regard to workplace ergonomics, there was not enough evidence from the scientific literature to guide current practices. Based on the scientific literature, participatory ergonomics and multifaceted workplace interventions seem to have no beneficial effect on reducing MSD among this group of workers. As these interventional domains were very heterogeneous, it should also be recognized that general conclusions about their effectiveness should be done with care.Systematic review registration PROSPERO CRD42018116752 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=116752).

Bioarchaeological Analysis of Remains

Presumably in constructing the sidewalk, the bones from these shallow burials were disposed of elsewhere. Remains of five adults and one child were excavated. Seven subadult teeth were surface-collected around a hole at the western edge of the site. Being buried in moist sand meant that most bones excavated were fragmented. Bones and teeth were examined for evidence of pathologies. This small sample is not representative of the community, but the pathologies provide insight on these persons’ lives. The linea aspera on the only femur excavated is fairly robust. The individual’s sex was indeterminate, but this ambiguity reinforced the point that both men and women in this community engaged in physically demanding work. Cranial fragments from two individuals were thickened, an indicator of anemia resulting from nutritional deficiency or disease. Cribra orbitalia was noted in the eye socket of one individual, another indicator of nutritional deficiency. Two of the child’s incisors have transverse lines, evidence of enamel hypoplasia, an indicator of infectious disease and nutritional stress. Individuals buried in this cemetery were likely of low social status, living in congested and unsanitary conditions with limited food. These pathologies raise questions about the extent these conditions existed among African-Bahamian communities. Economic opportunities for free and enslaved workers would have been limited.