EUSOBI Young Physician-Scientist Grant Presentation: Camouflaged cardiac alert: Correlation of breast vascular calcification with intima media thickness - surrogate marker of cardiac health

Chronic kidney disease is associated with a high mortality rate, especially cardiovascular disease associated with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing the occurrence of vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The aim of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing hemodialysis. In this cross section, the concentration of sclerostin was measured by examination of enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are declared high if above 162 pg / ml there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis duration is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.

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Association Between Carotid Artery Intima-Media Thickness and Combinations of Mild Cognitive Impairment and Pre-Frailty in Older Adults

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16162978 ◽

2019 ◽

Vol 16 (16) ◽

pp. 2978

Author(s):

Jinkee Park ◽

Jong-Hwan Park ◽

Hyuntae Park

Keyword(s):

Older Adults ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Surrogate Marker ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Analysis Of Covariance ◽

Frailty Status ◽

Media Thickness

Carotid intima-media thickness (CIMT) has been proposed as a surrogate marker of cardiovascular disease. Mild cognitive impairment (MCI) and pre-frailty are reportedly associated with increased CIMT. As the evidence on the association of CIMT with combinations of MCI and pre-frailty is limited, this association is examined. A total of 231 older adults participated. MCI was defined according to clinical consensus or psychometric criteria by a dementia specialist, and considering detailed neuropsychological assessments. Also, pre-frailty was defined as subjects with frail component of 1 or 2. Carotid variables were measured using a B-mode ultrasound. The analysis of covariance (ANCOVA) was performed to assess independent differences in CIMT among the four groups, according to the cognitive function and frailty status after a multivariate adjustment. Increased CIMT is associated with combinations of MCI and pre-frailty. ANCOVA showed that CIMTs were significantly different among the four groups according to the cognitive function and frailty status. CIMTmax combined with MCI and pre-frailty was the thickest (1.04 ± 0.3 mm), whereas the CIMT of no MCI and no pre-frailty was the thinnest (0.82 ± 0.2 mm). The results suggest that combinations of MCI and pre-frailty are associated with increased CIMT in older adults.

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Abstract 111: Effect of Thyroxin Treatment on Carotid Intima Media Thickness (CIMT) Reduction in Patients With Subclinical Hypothyroidism (SCH)-A Meta-Analysis of Randomized Clinical Trials

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.37.suppl_1.111 ◽

2017 ◽

Vol 37 (suppl_1) ◽

Author(s):

Yugandhar Kandimalla ◽

Muhammad Aziz ◽

Archana Machavarapu ◽

Rehan Malik ◽

Adnan Younus ◽

...

Keyword(s):

Clinical Trials ◽

Subclinical Hypothyroidism ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Hormone Replacement ◽

Surrogate Marker ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Post Treatment ◽

Media Thickness

Background: Research shows that subclinical hypothyroidism (SCH) is related to increased carotid intima media thickness (CIMT), a surrogate marker of stroke and subclinical cardiovascular disease (CVD). It is controversial whether SCH should be treated or not to reduce risk of stroke and CVD morbidity and mortality. The aim of this meta-analysis was to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether thyroxin therapy in SCH can reverse the change in CIMT. Methods: Two independent reviewers did an extensive database search up to December 2016. Total of 12 randomized clinical trials discussed effect of thyroxin treatment on CIMT values at pre-and-post treatment in SCH subjects. Results: CIMT was significantly higher among SCH (n=280) as compared to EU controls (n=263) at baseline, pooled standardized mean difference (SMD) of CIMT was 0.44 mm [95%CI 0.14, 0.74], SE=0.15; p=0.004 with heterogeneity I 2 = 65%. After treatment with thyroxin in SCH subjects (n=314), there was a statistically significant decrease in CIMT from pre-to-post treatment, pooled SMD of CIMT decrease was [SMD -0.32; 95%CI (-0.47, -0.16), SE=0.08; p<0.0001, with heterogeneity I 2 = 2%], and was no longer different from EU controls [SMD 0.13 mm; 95% CI (-0.04, 0.30); p= 0.14; I 2 = 27%]. The total cholesterol, triglycerides, and low density lipoprotein were higher in SCH as compared to EU controls and decreased significantly after treatment with thyroxin. Conclusion: This meta-analysis shows that thyroxin therapy in SCH subjects significantly decreases CIMT and improves lipid profile, modifiable risk factors for stroke and CVD. Thyroid hormone replacement in SCH subjects might have a role in slowing down or preventing progression of atherosclerosis.

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Major dietary patterns and carotid intima-media thickness in Bangladesh

Public Health Nutrition ◽

10.1017/s136898001500124x ◽

2015 ◽

Vol 19 (2) ◽

pp. 218-229 ◽

Cited By ~ 5

Author(s):

Tyler R McClintock ◽

Faruque Parvez ◽

Fen Wu ◽

Tariqul Islam ◽

Alauddin Ahmed ◽

...

Keyword(s):

Low Income ◽

Surrogate Marker ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Low Income Countries ◽

Vegetable Diet ◽

Media Thickness ◽

Balanced Diet ◽

Root Vegetable ◽

Cardiovascular Morbidity And Mortality

AbstractObjectiveCarotid intima-media thickness (IMT) is a validated surrogate marker of preclinical atherosclerosis and is predictive of cardiovascular morbidity and mortality. Research on the association between IMT and diet, however, is lacking, especially in low-income countries or low-BMI populations.DesignCross-sectional analysis. Dietary intakes were measured using a validated, thirty-nine-item FFQ at baseline cohort recruitment. IMT measurements were obtained from 2010–2011.SettingRural Bangladesh.SubjectsParticipants (n 1149) randomly selected from the Health Effects of Arsenic Longitudinal Study, an ongoing, population-based, prospective cohort study established in 2000. Average age at IMT measurement was 45·5 years.ResultsPrincipal component analysis of reported food items yielded a ‘balanced’ diet, an ‘animal protein’ diet and a ‘gourd and root vegetable’ diet. We observed a positive association between the gourd/root vegetable diet and IMT, as each 1 sd increase in pattern adherence was related to a difference of 7·74 (95 % CI 2·86, 12·62) μm in IMT (P<0·01), controlling for age, sex, total energy intake, smoking status, BMI, systolic blood pressure and diabetes mellitus diagnoses. The balanced pattern was associated with lower IMT (−4·95 (95 % CI −9·78, −0·11) μm for each 1sd increase of adherence; P=0·045).ConclusionsA gourd/root vegetable diet in this Bangladeshi population positively correlated with carotid IMT, while a balanced diet was associated with decreased IMT.

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Mo-S6:5 Arterial intima-media thickness as a surrogate marker for atherosclerosis - regulatory perspective in EU

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)80133-9 ◽

2006 ◽

Vol 7 (3) ◽

pp. 43

Author(s):

J.T. Salonen

Keyword(s):

Surrogate Marker ◽

Intima Media Thickness ◽

Media Thickness ◽

Regulatory Perspective ◽

Arterial Intima

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Anterior Tragal Crease Is Associated With Atherosclerosis: A Study Evaluating Carotid Artery Intima–Media Thickness

Angiology ◽

10.1177/0003319716685481 ◽

2017 ◽

Vol 68 (8) ◽

pp. 683-687 ◽

Cited By ~ 5

Author(s):

Pawinee Rerknimitr ◽

Korbkarn Pongpairoj ◽

Chanat Kumtornrat ◽

Ratchathorn Panchaprateep ◽

Cameron P. Hurst ◽

...

Keyword(s):

Carotid Artery ◽

Health Care Professionals ◽

Venous Blood ◽

Univariate Analysis ◽

Clinical Signs ◽

Surrogate Marker ◽

Density Lipoprotein ◽

High Sensitivity ◽

Intima Media Thickness ◽

Media Thickness

The utility of the ear crease sign, anterior tragal crease (ATC), as a marker of atherosclerosis is yet to be established. The intima–media thickness of the common carotid artery (IMT-CCA) has been used as a noninvasive surrogate marker for atherosclerosis. History of traditional risk factors for atherosclerosis was obtained from 147 volunteers; ear examination was also performed and venous blood was drawn for laboratory analysis. The volunteers then underwent an ultrasonography measurement of the IMT-CCA. In univariate analysis, presence of ATC, age, underlying hypertension, diabetes mellitus, ischemic heart disease, cerebrovascular disease, cigarette smoking, low-density lipoprotein, and high-sensitivity C-reactive protein were significantly associated with the IMT-CCA. Further multivariate analysis confirmed a significant association between the presence of ATC and IMT-CCA, when adjusted for other factors (adjusted βATC = .010, 95% confidence interval: 0.0021-0.019). Anterior tragal crease is a potential clinical sign that can predict atherosclerosis. The sign is easily recognizable and may help health-care professionals to identify those at risk of atherosclerosis, especially in people with no clinical signs of the disease.

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The Association between the Activin A Serum Level and Carotid Intima-Media Thickness in Chronic Kidney Disease Patients

International Journal of Nephrology ◽

10.1155/2020/8893653 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Ade Yonata ◽

Zulkhair Ali ◽

Taufik Indrajaya ◽

Erial Bahar ◽

Ian Effendi ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Serum Level ◽

Vascular Calcification ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Activin A ◽

Enzyme Linked Immunosorbent Assay ◽

Media Thickness ◽

Imaging Results

Introduction. Chronic kidney disease (CKD) is associated with high mortality rates, mainly as a result of cardiovascular complications. Meanwhile, recent studies have suggested a role of a homodimer protein called activin A in chronic kidney disease-mineral and bone disorder (CKD-MBD) conditions that may exist in the vascular calcification and osteolytic process. Ultrasound examination of the carotid intima-media thickness (cIMT) is a noninvasive method to assess vascular calcification. This study aimed to analyze the relationship between the activin A serum level and cIMT in patients with CKD at Mohammad Hoesin Hospital, Palembang, Indonesia. Methods. We conducted a hospital-based, cross-sectional study of consecutive CKD patients at the Department of Internal Medicine, Mohammad Hoesin Hospital, from July to November 2019. The level of activin A was measured by enzyme-linked immunosorbent assay. Meanwhile, cIMT measurements were collected by B-mode ultrasound imaging. Results. A total of 55 patients with CKD were included in this investigation. The median serum activin A level in these patients was 236.17 (116.33–283) pg/mL, while the median cIMT was 0.8 (0.6–1.45) mm. A relationship between the serum activin A level and cIMT (r = 0.449; p = 0.001 ) was observed. During multivariate analysis with linear regression, triglyceride p = 0.049 , phosphate p = 0.005 , and activin A p = 0.020 serum levels were factors associated with cIMT. Conclusion. In this study, a relationship between the activin A serum level and cIMT in patients with CKD was identified. Vascular calcification should be screened for in all CKD patients by the measurement of cIMT.

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P261 The relationship between carotid intime-media thickness and modified gensini score in patients with acute coronary syndrome

European Heart Journal ◽

10.1093/ehjci/ehz872.086 ◽

2020 ◽

Vol 41 (Supplement_1) ◽

Author(s):

M Y Nguyen Hoang Tai ◽

PHUONG Huynh Kim ◽

NGHIA Nguyen Thuong

Keyword(s):

Acute Coronary Syndrome ◽

Coronary Atherosclerosis ◽

Surrogate Marker ◽

Duplex Ultrasound ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Gensini Score ◽

Cross Sectional ◽

Coronary Syndrome ◽

Media Thickness

Abstract Introduction Detection of extent and severity of atherosclerosis using easy, non-invasive methods is of great importance. Coronary atherosclerotic burden may be evaluated with the modified Gensini score (mGSS) while carotid intima media thickness (CIMT) is well known as a surrogate marker of atherosclerosis. Aim To investigate whether CIMT is a predictor of coronary atherosclerosis in Vietnamese patients. Methods This is a cross-sectional study of 276 patients who was diagnosed index acute coronary syndrome and underwent coronary angiography. mGSS was used to determine the extent and severity of coronary atherosclerosis. CIMT was estimated by carotid duplex ultrasound. Results In 276 patients, there were 192 men and 84 women, with ages ranging from 24 to 90 years. Median CIMT was 0.76mm (IQT 0.26mm); median mGSS was 140 (IQT 70). CIMT and mGSS were correlated with age (r= 0.269, p< 0.001 and r= 0.134, p< 0.001). CIMT were also correlated with vessels score (r= 0.222, p< 0.001), with stenosis score (r= 0.214, p< 0.001) and with the mGSS (r= 0.216, p< 0.001). This correlation were significantly recognized between groups with or without elevated CIMT. Conclusion Our data suggests that CIMT correlates positively with the extent and severity of coronary atherosclerosis. CIMT may be useful as a screening tool for the presence of CAD in Vietnamese population.

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