Pasang Surut Pemikiran Al-Syafi’I Telaah Pemikiran Qaul Qadim dan Qaul Jadid dengan Pendekatan Teori Siklus Ibnu Khaldun

This article discusses the ups and downs of al-Shafi'i's thinking, which are three periods. First, the learning period, is the period when al-Shafi'i in Mecca, Medina, Yemen, Iraq first (pre-Baghdad). second, the period where al-Shafi'i resided in Iraq, qaul qadim, third, the period when al-Shafi'i lived in Egypt, qaul jadid. This library research examines and reveals the following issues: what are the factors behind the change in the law thoughts of al-Shafi'i ? And how did al-Shafi'i's thoughts change according to the perspective of Ibn Khaldun's cycle theory ?, using the law sociology approach, that is Ibn Khaldun's cycle theory as a knife of analysis. The theory conceptualizes the change in civilization from the condition of badawah as a condition of beginning and formation, hadarah as a phase of development and progress, to the condition of inqiradh, a period of decline. Changes in the law thoughts of al-Shafi'i from pre-qaul qadim, qaul qadim to qaul jadid were motivated and influenced by several things, namely: geographical factors, cultural factors and customs, scientific factors, social factors, economic factors, political factors, and difference factor in the use of theorem. Whereas the change experienced three conditions, namely the condition of badawah for the pre-qaul qadim phase, the condition of hadarah for the qaul qadim period, and the condition of inqiradh, during the qaul jadid period.

In vitro Pharmaceutical Equivalence Study of Three Brands of Atenolol Tablets Available in Bangladesh

The aim of the present work was to assess the pharmaceutical equivalence of three brands of atenolol (50 mg) tablets available in Bangladesh using in vitro dissolution study. The dissolution study was carried out using the paddle apparatus according to the guidelines of United States Pharmacopoeia (USP). The dissolution profiles of three locally manufactured atenolol tablets were determined and compared with the dissolution profile of atenolol tablet from innovator’s company. All samples attained more than 85% dissolution within 10 minutes. Mean dissolution values were employed to estimate difference factor (f1) and similarity factor (f2). Difference factor (f1) and similarity factor (f2) were used to assess in vitro bio-equivalency among the three brands. Other general quality assessment parameters such as hardness, friability and disintegration time were also determined. All brands complied with the official specifications for hardness, friability and disintegration time. The study indicated that all brands can be prescribed interchangeably. Dhaka Univ. J. Pharm. Sci. 18(1): 43-48, 2019 (June)

The one and the many: Both/and reasoning and the embracement of pluralism

This article outlines the basic structure of a Pluralistic Thinking Model (PTM). The model posits the activity of endorsing multiplicity and complexity as an individual difference factor. Pluralistic thinking is neither the reverse of prejudice, nor synonymous with multiculturalism, and deserves a conceptual space of its own. At its foundation lies a style of interpreting the world through a “both/and” lens. The PTM posits five drivers of pluralism: cognitive attributes, motivational factors (emotional and personality traits), a developmental trajectory, personal experience, and socio-cultural surround. Each of these is supported by research findings. While pluralism may lead to a sustainable embracement of diversity, it is challenging to maintain across domains and targets, indicating its domain-specificity. This paper presents two new tools for measuring pluralistic thinking: the Pluralistic Thinking Scale (PTS) and the Magic Wand Survey (MWS). Suggestions are offered for further exploration of the concept and for its social and ethical implications.

Reactivity to unpredictable threat as a treatment target for fear-based anxiety disorders

BackgroundHeightened reactivity to unpredictable threat (U-threat) is a core individual difference factor underlying fear-based psychopathology. Little is known, however, about whether reactivity to U-threat is a stable marker of fear-based psychopathology or if it is malleable to treatment. The aim of the current study was to address this question by examining differences in reactivity to U-threat within patients before and after 12-weeks of selective serotonin reuptake inhibitors (SSRIs) or cognitive-behavioral therapy (CBT).MethodsParticipants included patients with principal fear (n = 22) and distress/misery disorders (n = 29), and a group of healthy controls (n = 21) assessed 12-weeks apart. A well-validated threat-of-shock task was used to probe reactivity to predictable (P-) and U-threat and startle eyeblink magnitude was recorded as an index of defensive responding.ResultsAcross both assessments, individuals with fear-based disorders displayed greater startle magnitude to U-threat relative to healthy controls and distress/misery patients (who did not differ). From pre- to post-treatment, startle magnitude during U-threat decreased only within the fear patients who received CBT. Moreover, within fear patients, the magnitude of decline in startle to U-threat correlated with the magnitude of decline in fear symptoms. For the healthy controls, startle to U-threat across the two time points was highly reliable and stable.ConclusionsTogether, these results indicate that startle to U-threat characterizes fear disorder patients and is malleable to treatment with CBT but not SSRIs within fear patients. Startle to U-threat may therefore reflect an objective, psychophysiological indicator of fear disorder status and CBT treatment response.

Uji Disolusi Terbanding Tablet Ofloxacin Berlogo dan Generik Bermerek Terhadap Inovator Dalam Media Dapar HCl pH 4,5

ABSTRAK Uji disolusi terbanding merupakan pengujian yang dapat digunakan untuk memastikan ekivalensi dan sifat-sifat produk obat. Uji disolusi terbanding dilakukan dalam media disolusi dengan pH yang disesuaikan dengan kondisi in vivo yaitu pada pH 1,2; 4,5; dan 6,8. Obat generik dan generik bermerek yang wajib uji ekivalensi salah satunya yaitu ofloxacin. Ofloxacin merupakan suatu obat yang memiliki sifat kationik, anionik, dan zwitter ion. Penelitian ini bertujuan untuk menentukan ekivalensi profil disolusi terbanding yang dianalisis dengan parameter f1, f2, dan DE70 antara ofloxacin generik berlogo dan generik bermerek terhadap inovator dalam media dapar asetat pH 4,5. Uji disolusi dilakukan sesuai USP 32-NF 27 yaitu menggunakan alat uji tipe 2 pada suhu 37 ± 0,50C dengan kecepatan putar 50 rpm. Analisis hasil yang digunakan untuk menentukan ekivalensi profil disolusi yaitu difference factor (f1), similarity factor (f2), dan dissolution efficiency (DE70). Hasil penelitian ini memberikan kesimpulan bahwa sampel yang memiliki ekivalensi profil disolusi terbanding yang dianalisis dengan parameter f1, f2, dan DE70 terhadap produk inovator dalam media dapar asetat pH 4,5 yaitu sampel A (generik bermerek) dan sampel B (generik berlogo). Kata kunci : ofloxacin, disolusi terbanding, difference factor (f1), similarity factor (f2), dan dissolution efficiency (DE70). ABSTRACT Comparative dissolution is a test that can be used to ensure equivalence and properties of medicinal products. Comparative dissolution test has done in a dissolution medium with pH adjusted to in vivo conditions at pH 1,2; 4,5; and 6,8. One of generic and generic branded drug that need equivalence test is ofloxacin. Ofloxacin is a drug which are cationic, anionic, and zwitter ion. The aim of this study was to determine equivalence comporative of dissolution profiles, then analyzed with f1, f2, and DE70 parameters between generic and generic branded to innovators ofloxacin in media acetate buffer pH 4,5. Dissolution test was accordance to USP 32-NF 27 that used equipment test type 2 at temperature 37 ± 0,50 C with rotary speed 50 rpm. The analysis results were used to determine equivalence dissolution profile e.g. difference factor (f1), similarity factor (f2), and dissolution efficiency (DE70). The results this study showed that samples had equivalence comporative of dissolution profiles which were analyzed with f1, f2, and DE70 parameters to innovator product in media acetate buffer pH 4,5 was sample code A (generic branded) and sample code B (generic). Keywords: ofloxacin, comparative dissolution, difference factor (f1), similarity factor (f2), and dissolution efficiency (DE70).