A number of North American artist project spaces established in 2003 activated alternatives to display and programming practices found in mainstream museums, giving voice to artists who did not fit existing durational, disciplinary and authorial parameters. One such site was Elsewhere in Greensboro, North Carolina, an artist residency and living museum set within a 1930s Depression-era thrift store. Here, an archival approach emerged from the mess of thrift store Americana that considered what an artist project space could be if nothing was sold, altered beyond repair or thrown away. Central to the artist organizing practices that emerged on-site are archival principles that enable empathetic connections to form in relation to object meanings, lost subjectivities and neighbourhood relationships. Elsewhere, as a site, offered a means for hidden voices to be heard and alternative archiving practices to be tested as a form of community memory, with their museological presentation indebted to the implications of mess and its endless reordering. This article builds on the idea of empathy as a capacity to be engendered in museum audiences by seeing it also as a structuring principle to invoke organizational difference at every turn. Such structural empathy became tellingly significant in 2020 as racial justice protests and the COVID-19 pandemic underscored the inequities of American life. For Elsewhere, the principles of practice that enabled them to become a platform for imagining and securing hyper-local change are bound to successive reformulations of both the site since 2003 and the resulting archive.