Phytoclimatic spectrum of Weeds flora of Toormang Valley, Dir Lower, Koh-E-Hindukush Range, Pakistan

Four season’s data of floristic structure and biological spectrum of Toormang Valley, Dir lower was explored during 2018-2019. The flora comprised 238 species, 164 genera associated with 60 families. The most prevailing family was Asteraceae with 42 species (17.64%), trailed by Rosaceae 16 (6.72%), Brassicaceae 13(5.46%), Solanaceae 11 (4.62%), Papilionaceae 10 (4.20%), Apiaceae, and Poaceae each with 9(3.78%), Lamiaceae 8 (3.36%), Boraginaceae, Euphorbiaceae and Moraceae each contributed by 7 species (2.94%), Amaranthaceae and Cucurbitaceae each consisted of 6 species (2.52%), Caryophyllaceae and Chenopodiaceae each with 5(2.10%) while rest of 23 families contributed by 01 species each (0.42%). The largest genera were Euphorbia (6 species), followed by Sonchus and Medicago (4 species) each. Therophytes were the dominant with 102 species (42.85%), followed by nanophanerophytes with 27 (11.34%), hemicryptophytes with 25 (10.50%), chamaephytes with 20(8.40%), microphanerophytes with 18(7.56%), megaphanerophytes with 16(6.72%), geophytes with 15 (6.30%), mesophanerophytes with 14 (5.88%) and parasite with 1 species (0.42%). The observations on leaf size revealed that microphyll was the prevailing class with 73 species (30.67%), followed by mesophyll 69(28.99%), nanophyll 60 (25.21%), leptophyll 23(9.66%), macrophyll 8(3.36%), megaphylly 4(1.1.68%) and aphyllous with 1 species (0.42%). Simple lamina species 154 while 5 species have spiny lamina shape.

FLORISTIC COMPOSITION AND BIOLOGICAL SPECTRUM OF BARA GALI, ABBOTTABAD

Floristic composition and Phytosociological studies on the flora of Bara Gali District Abbottabad, Pakistan was conducted. The altitudinal range of the Bara Gali is from 2100-2370 meter. From the study area 50 species belong to 33 families were recorded. Herbaceous flora was dominant with 35 species, shrubs with 10 species and tree with 5 species. Asteraceae was dominant having 6 species. Microphyll dominant leaf size spectra and hemicryptophytes were dominant life form in the study area. This study provide information about the floristic composition of Bara Gali.

Taxonomic and ecological analysis of flora at locality „Djavolja Varoš“ (South Serbia)

Djavolja Varoš, one of the most atractive natural geological formations of errosive origin in Serbia, is situated in the south of the country, and protected by national legislation as a Natural Monument. The taxonomic and ecological analysis of flora in this area has not been processed yet, so we performed a survey of flora in this locality. Plant species were collected, herbarized, and taxonomic and biological spectrum analyses were conducted. This field study revealed that the vascular flora of the study area was made up of 130 constituent species, which belonged to 81 genera and 41 families. The biological spectrum of the flora is characterised by high presence of hemicryphytes (38%) and geophytes (20%).

An updated checklist of bryophytes for the state of Paraíba, a Brazilian hotspot: new records and biological spectrum in a Seasonally Dry Tropical Forest fragment

As a result of bryological explorations in the the state of Paraíba (Brasil), a total of 36 bryophtes belonging to 18 genera and 14 families were identified from a Seasonally Dry Tropical Forest fragment. Of these, 17 taxa are liverworts and 19 taxa are mosses. In addition, we added nine new records for the bryophyte flora of state of Paraíba with this paper. Among them, two mosses (Rhodobryum roseum and Cryphaea filiformis) and two liverworts (Caudalejeunea lehmanniana and Cheilolejeunea conchifolia) are for the first time in dry tropical forest.

Bis-triazole-containing compounds with anticancer potential: A short review

: The development of novel anticancer agents with high efficiency is of great importance due to the severe anticancer scenario of the currently used drugs. Dimerization is a useful method to develop new drug candidates with a broad biological spectrum, enhanced activity and potency to overcome drug resistance. A wide variety of bis-triazole-containing compounds have been developed with improved properties compared with their parent compounds. These derivatives could inhibit tumor proliferation, invasion and metastasis, revealing their potential as putative anticancer candidates. This review covers the recent advances of bis-triazole-containing compounds as anticancer candidates, and the structure-activity relationship are also discussed to set up the direction for the design and development of bis-triazole-containing compounds with higher efficiency.

Hepatoblastomas with carcinoma features (HBCs) represent a biological spectrum of aggressive neoplasms in children and young adults

Malignant hepatocellular cancers are the most common primary liver malignancies in children, and hepatoblastomas (HBs) account for more than two-thirds of these cases. While most HBs respond to chemotherapy and have favorable outcomes, the 3-year overall survival rate for high-risk HBs is below 50% and guidelines for their classification and treatment are still evolving. HB risk-stratification efforts using clinical, histological, and molecular parameters have been reported to help identify patients that require more or less aggressive therapies in retrospective studies, and are being validated in clinical trials. However, risk assessment is particularly challenging for cancers with certain histologies, including tumors in the recently proposed provisional hepatocellular neoplasm not otherwise specified (HCN NOS) category. HCN NOSs exhibit either intermediate or combined HB and hepatocellular carcinoma (HCC) histological features, and while neoplasms with such features were observed over a decade ago, only a handful have been characterized and little is known about their biology and clinical features. Here, we molecularly characterized a series of clinically annotated HCN NOSs that demonstrated either intermediate HB/HCC histology or distinct coexisting areas with HB and HCC histological features. In addition, molecular profiling of HBs demonstrating focal pleomorphism or anaplasia (HB FPA) after chemotherapy revealed underlying biological features previously observed in HCCs. Our study suggested that HCN NOSs and HB FPAs are aggressive tumors, irrespective of patient age or resectability. Consequently, we designated them collectively as HBs with carcinoma features (HBCs) and outlined histological and molecular characteristics for their diagnosis and treatment. In our single-institution study, transplanted HBC patients were significantly and more than twice as likely to have good outcomes, highlighting the importance of molecular testing and aggressive early intervention.

Autoimmune hypoglycemia expands the biological spectrum of HHV8+ multicentric Castleman disease

Key Points Autoimmune hypoglycemia belongs to the clinical spectrum of HHV8+ MCD and rituximab is an effective treatment of this condition. This rare complication is related to autoantibodies directed toward the insulin receptor and activating the insulin signaling pathway.

FLORISTIC DIVERSITY OF THE OULED BECHIH FOREST (ALGERIA)

The objective of this study is to inventory the flora of the Ouled Bechih forest (Algeria) with a quantitative and qualitative analysis through significant parameters. This study allowed the identification of 27 species belonging to 26 genera and 17 families. The results show an important diversity of the regional flora which is essentially dominated by the Asteraceae, Fabaceae, Fagaceae and Rosaceae. Hemicryptophytes and geophytes dominate the biological spectrum of the flora of this forest, which is morphologically characterised by the dominance of perennial herbs. The analysis of the chorological types shows the predominance of the Mediterranean element.