Phage-Choline Kinase Inhibitor Combination to Control Pseudomonas aeruginosa: A Promising Combo

Background: : Pseudomonas aeruginosa is one of the most prevalent opportunistic pathogens in humans that has thrived and proved to be difficult to control in this “post-antibiotic era.” Antibiotic alternatives are necessary for fighting against this resilient bacterium. Even though phages might not be “the wonder drug” that solves everything, they still provide a viable option to combat P. aeruginosa and curb the threat it imposes. Main findings: : The combination of antibiotics with phages, however, poses a propitious treatment option for P. aeruginosa. Choline kinase (ChoK) is the enzyme that synthesizes phosphorylcholine subsequently incorporated into lipopolysaccharide located at the outer membrane of gram-negative bacteria. Recently, inhibition of ChoKs has been proposed as a promising antibacterial strategy. Successful docking of Hemicholinium-3, a choline kinase inhibitor, to the model structure of P. aeruginosa ChoK also supports the use of this inhibitor or its derivatives to inhibit the growth of this microorganism. Conclusion: : Therefore, the combination of the novel antimicrobial “choline kinase inhibitors (ChoKIs)” with a phage cocktail or synthetic phages as a potential treatment for P. aeruginosa infection has been proposed.

A rare case of recurrent paroxysmal supraventricular tachycardia in pregnancy managed with adenosine, a wonder drug

Paroxysmal supraventricular tachycardia (PSVT) is the most common sustained arrhythmia during pregnancy and a challenging situation due to lack of evidence based guidelines. About 50% of PSVT, who fail to respond to vagal maneuvres, responds to therapies as pharmacologic agents as adenosine and electrocardioversion. We reported a case of 29 years old primigravida women with no organic heart disease who presented at 21 weeks of period of gestation with complaints of palpitations and shortness of breath. Her ECG revealed PSVT for which she received adenosine as anti-arrhythmic for conversion to sinus rhythm. She was started prophylactically on tablet metoprolol 25 mg twice daily, as advised by cardiologist. In third trimester, she had recurrent episodes of PSVT for which she received adenosine in emergency department. She delivered a healthy female baby by an elective caesarean section done under spinal anesthesia. Fortunately, her intraoperative and postpartum was uneventful with no recurrence of PSVT during hospital stay. She was discharged on day 4 of caesarean section on tablet metoprolol 12.5 mg twice daily and followed in postpartum period for complications. To summarize, PSVT occurring during pregnancy, labour or at caesarean section is not uncommon. Treatment remains a challenge though, as clinical decision must be tackled with appropriate consideration of both maternal and fetal factors. So, multi-disciplinary approach is needed for treatment including obstetrician, cardiologists, physician and neonatologists. Our case highlighted the necessity of keeping anti-arrhythmic drugs such as adenosine readily available on the labour ward.

Triphala: A Wonder Drug of Ayurveda

Triphala is used in the traditional Indian system of medicine. Triphala is composed of three fruits namely Haritaki, Vibhitaki, Amalaki. The fruit of three together called Triphala. It is widely prescribed Ayurvedic drug and is used in various diseases. Triphala is a traditional Ayurvedic formula that tones and supports normal function to the bowel. This three fruit formula is simply a bowel toner, designed to store the muscular function and contractibility of the intestinal wall. It is used as an anti oxidant and possesses various beneficial properties. Key words: Triphala, Ayurveda, Charak Samhita, Sushruta Samhita, Astanga Hridaya.

A Micronutrient Mixture may Reduce the incidence and Improve the Effectiveness of Drug Therapy of Alzheimer’s Disease

Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are used for traditional and herbal medicine. The plant Costus spicatus commonly known as ‘Spiral ginger’ as ‘insulin plant’, a wonder drug down blood sugar level and hypoglycemic properties. The plant has been found to have numerous pharmacological exercises, for example, antibacterial, antifungal, anticholineesterase, cancer prevention agent, antihyperglycemic, calming, pain relieving, antipyretic, antidiuretic, antistress and estrogenic action. The rhizomes of Costus species are harsh, astringent, bitter, cooling, love potion, laxative, anthelminthic, depurative, febrifuge, expectorant, tonic, improve assimilation, and is an energizer herb that clears poisons. It additionally has against richness, anabolic properties. This audit plainly demonstrates the need to perform logical investigations with therapeutic vegetation featuring potential for Costus species because of its antidiabetic, pharmacological and cell reinforcement properties. The rhizome is credited with purgative and tonic properties. India is a botanical garden of the world for natural resources.

A Literature Review of Anti- Diabetic Medicinal Plant Properties (Costus speices)

Costus species is a significant restorative and decorative plant used to fix various illnesses. In India 6,000 plants are used for traditional and herbal medicine. The plant Costus spicatus commonly known as ‘Spiral ginger’ as ‘insulin plant’, a wonder drug down blood sugar level and hypoglycemic properties. The plant has been found to have numerous pharmacological exercises, for example, antibacterial, antifungal, anticholineesterase, cancer prevention agent, antihyperglycemic, calming, pain relieving, antipyretic, antidiuretic, antistress and estrogenic action. The rhizomes of Costus species are harsh, astringent, bitter, cooling, love potion, laxative, anthelminthic, depurative, febrifuge, expectorant, tonic, improve assimilation, and is an energizer herb that clears poisons. It additionally has against richness, anabolic properties. This audit plainly demonstrates the need to perform logical investigations with therapeutic vegetation featuring potential for Costus species because of its antidiabetic, pharmacological and cell reinforcement properties. The rhizome is credited with purgative and tonic properties. India is a botanical garden of the world for natural resources.

GILO (TINOSPORA CORDIFOLIA (WILLD.) MIERS: A WONDER DRUG OF UNANI SYSTEM OF MEDICINE

Gilo or Tinospora cordifolia is considered as a wonder drug of Unani System of Medicine because of its broad-spectrum therapeutic properties. It is an herbaceous vine, commonly grown in tropical India, and is being widely used in AYUSH system and unorganized systems (folk, tribal, native) of medicine. It is a storehouse of various phyto constituents like alkaloids, terpenoids, glycosides, hormones, polysaccharides, steroids, minerals etc. Its main pharmacological properties are antipyretic, anti-diabetic, antioxidant, hepato protective etc. Now a days, Gilo is being extensively assessed for its immunomodulator activity and it is proving to be a promising herb in this respect. The current study presents a critical review on the morphology, habitat, phytochemistry, pharmacological actions and therapeutic uses of this medicinal plant as mentioned in the classical literature of Unani System of Medicine as well as to cover its recent researches.