Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI

Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from low- and middle-income countries (LMICs) is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14–20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/day algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 were enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 × 2 = 400 mg/day) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (≤20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; n = 478 and placebo; n = 479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo groups for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, p = 0.54), length (47.3 ± 2.0 vs. 47.5 ± 2.0 cm, p = 0.13), or head circumference (33.7 ± 1.4 vs. 33.8 ± 1.4 cm, p = 0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, p = 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400 mg/day DHA did not impact the offspring‘s birthweight, length, or head circumference.

Prenatal Maternal Docosahexaenoic Acid (DHA) Supplementation and Newborn Anthropometry in India: Findings from DHANI

Long-chain omega-3 fatty acid status during pregnancy may influence newborn anthropometry and duration of gestation. Evidence from high-quality trials from LMICs is limited. We conducted a double-blind, randomized, placebo-controlled trial among 957 pregnant women (singleton gestation, 14-20 weeks’ gestation at enrollment) in India to test the effectiveness of 400 mg/d algal docosahexaenoic acid (DHA) compared to placebo provided from enrollment through delivery. Among 3379 women who were screened, 1171 were found eligible; 957 enrolled and were randomized. The intervention was two microencapsulated algal DHA (200 X 2= 400 mg/d) or two microencapsulated soy and corn oil placebo tablets to be consumed daily from enrollment (20 weeks) through delivery. The primary outcome was newborn anthropometry (birth weight, length, head circumference). Secondary outcomes were gestational age and 1 and 5 min Appearance, Pulse, Grimace, Activity, and Respiration (APGAR) score. The groups (DHA; n=478 and placebo; n=479) were well balanced at baseline. There were 902 live births. Compliance with the intervention was similar across groups (DHA: 88.5%; placebo: 87.1%). There were no significant differences between DHA and placebo group for birth weight (2750.6 ± 421.5 vs. 2768.2 ± 436.6 g, p=0.54), length (47.3 ± 2.0 vs. 47.5 ±2.0 cm, p=0.13) or head circumference (33.7 ± 1.4 vs 33.8 ± 1.4 cm, p=0.15). The mean gestational age at delivery was similar between groups (DHA: 38.8 ± 1.7 placebo: 38.8 ± 1.7 wk, p= 0.54) as were APGAR scores at 1 and 5 min. Supplementing mothers through pregnancy with 400mg/d DHA did not impact the offspring birthweight, length or head circumference.

Estimation Model On Newborn Anthropometry Based On Mid- Upper Arm Circumference (MUAC)

The measurement of MUAC is a way to identify the risk of chronic energy deficiency (CED). Pregnant women with CED are at risk of delivering Low Birth Weight Babies (LBW), short body length babies (stunting). The objective: to analyze the accuracy and estimation prediction of MUAC measurements on Newborn anthropometry. The Method: The design of this study is descriptive korelatiff, with a cross sectional approach. Quota sampling sampling techniques were 30 mothers and newborn babies. The data is secondary data taken from KIA book. Analysis using Spearman rank test and linear regression. Results: The accuracy measurement of MUAC for birth weight was 81.6% (r = 0.903, r2 = 0.816, p value = .0001). The accuracy measurement of MUAC for the birth length of a baby was 45.9% (r = 0.691, r2 = 0.459, p value = 0.0001). Estimation model for a baby’s birth wieght : -639,540+139,240* MUAC (cm), Estimation model for noewborn’s length : 37,566+0.409* MUAC (cm). The conclusions: Every 1 cm increase in MUAC there is a baby's birth weight gain of 139.240 grams. Each increase of 1 cm of MUAC there is addition of length of newborn baby 0.409 cm.

The Relationship of The Weight of The Placenta With a Status of Newborn Anthropometry Aterm Area Clinics Kassi-Kasi Makassar

The phenomenon of sexual intercourse in women Premenopausal In Makassar city birth weight infants depends on the nutrition of mother and placenta's ability to transport nutrients from mother to fetus. The weight of the placenta, and the size and shape of the surface, reflecting its ability to transfer nutrients. The weight of the placenta is a measure commonly used to summarize the growth and function of the placenta. This research aims to analyze the relationship of the weight of the placenta with a status of newborn Anthropometry term. Type of this research is descriptive analytic with a cross-sectional design. The number of samples in this study was 59 people mother intrapartum taken by way of Simple Random Sampling. Data analysis was done with the chi-square test, with a confidence level of α = 0.05. Based on the results of this research noted that the value of significance p = 0,013 birth weight (p < 0.05), birth length p = 0.00 (p < 0.05), head circumference p = 0,010 (p < 0.05), the ratio of the weight of the placenta the normal 46 people (78%) abnormal 13 people (8.5%), and index ponderal baby normal 54 people (91.5%) and not normal 5 people (8.5%). Thus it can be concluded that there is a relationship between the weight of the placenta with a status of Anthropometry weight born babies, birth, body length and head circumference, but not with the ratio of the weight of the placenta and baby ponderal index

Serum Zinc Level at Term Pregnancy and Newborn Anthropometry

Objective: To determine the relationship between serum zinc level at term pregnancy and newborn anthropometry. Methods: This study is an observational study with cross-sectional design. Serum zinc level at term pregnancy was measured and then anthropometric measurement was done to the newborn, including birth weight, birth length and head circumference at birth. The data were statistically analyzed using regression correlation test. Results: Mean serum zinc level at term pregnancy is 36.01 μg/dl (SD=18.34 μg/dl), the average birth weight is 3158 gr (SD=480.4 gr), the average birth length is 48.42 cm (SD=1.75 cm) and the average head circumference at birth is 33.13 cm (SD=1.14 cm). There was no statistically significant relationship between serum zinc levels at term pregnancy and birth weight (p-value=0.152). Meanwhile, there are statistically significant relationships between serum zinc level at term pregnancy with birth length and head circumference with pvalue 0.026 and 0.012, respectively. Conclusion: Serum zinc level at term pregnancy is correlated with birth length and head circumference, but is not correlated with birth weight. [Indones J Obstet Gynecol 2015; 3-4: 190-195] Keywords: birth length, birth weight, head circumference at birth, serum zinc level, term pregnancy