461Alcohol use and anti-retroviral adherence among people living with HIV in ART centre of Nepal

Background Alcohol use is known to have higher prevalence among HIV infected individuals. Hazardous use of alcohol in many studies is negatively associated with the adherence to antiretroviral therapy. Use of alcohol and ART adherence among PLHIV is inadequately explored in Nepalese context. This study aimed at identifying the level of alcohol use and its relationship with adherence to ART among PLHIV. Methods A total of 205 PLHIV of age 18 years or more were randomly selected at a national ART centre of Nepal. Self-reported adherence questionnaire was used to get the level of adherence, Alcohol Use Disorder Identification Test (AUDIT) with five questions was adopted for screening the hazardous alcohol use. Those who took more than 95% of the prescribed doses were considered as adherent. Results About 86% of the respondents were adherent to ART in four days recall. About one third of the respondents were alcohol user and 40% of them had hazardous use of alcohol. Those having hazardous use of alcohol were four times (AOR=4.60, 95% CI 1.27,16.62) more likely to be non-adherent as compared to those who had not hazardous use of alcohol. Multivariate analyses adjusted ethnicity, Knowledge on dangers of non-adherence, subjective feeling of own health, use of memory aid, IDU background, treatment substitution and depression category. Conclusion Hazardous use of alcohol was independently associated with non-adherence with the ART. Key message Screening at the start of the treatment and intervention targeting alcohol use may improve HIV outcomes in individuals with hazardous alcohol use.

Cole Crops Disease Management Approaches Practiced by Farmers and its Impact on their Health: A Case Study of Nala, Kavre District of Nepal

A case study was conducted at Nala, Kavre district to assess the present cultivation and disease management status in cole crops in the year 2019 with use of semi-structured questionnaire among the local farmers. It was found that majority of respondent cultivated cole crops seasonally and faced five major disease problem in it namely: stalk root (Sclerotina sclerotiorum), Alternaria leaf spot (Alternaria brassicae and A. brassicicola), damping off (Pythium sp.), root rot (Rhizoctonia solani) and club root (Plasmodiophora brassicae). For management of those diseases, 83% respondent used conventional method of disease management i.e. chemical fungicides and insecticides. But the methods of management of disease was found significant with IPM training and awareness on biological approaches they have heard or related program attained. Almost 40% respondent had practices IPM packages of pest control based on training they have received and 33% has practiced based on the awareness program they have received. Also female guided farming has more probability to adapt IPM tools to minimize effect of pesticides and cooperatives had also played major role in mass communicating benefits of IPM. With 83% conventional management practicing farmers, they reported to face piles of immediate and chronic health issues due to continuous pesticidal use. Eye irritation (16.9%), skin problems (21.4%), headache (10.7%), respiratory problems (7.1%), and vomiting (5.3%), and chronically cancer (27.7%) was reported in the area due to prolonged and hazardous use of pesticides in conventional practices as per the respondents.

Factors associated with adherence to a web-based alcohol intervention among college students

This study aimed to evaluate the association between student characteristics and recruitment strategies in the adherence of college students to a web-based alcohol intervention. Participants were 46,329 Brazilian students aged from 18 to 30, who consumed alcohol during the past three months. Three recruitment strategies were implemented: open invitations, and personally-addressed invitations with or without non-monetary incentives. We evaluated the educational, sociodemographic, motivational, and alcohol consumption effects on adherence using logistic regression models. Women (aOR = 1.09 [1.04; 1.14]), students with higher income (aOR = 1.32 [1.21; 1.45]), and more motivated students (aOR = 1.04 [1.03; 1.05]) were more adherent to the intervention, as well as those reporting binge drinking (aOR = 1.26 [1.19; 1.33]) and alcohol hazardous use (aOR = 1.11 [1.05; 1.18]). The use of incentives was the main factor associated with adherence (aOR = 3.69 [2.46; 5.55]). Our results may help the development of future web-based interventions related to alcohol use.

A COMPARATIVE STUDY TO EVALUATE THE EFFECT OF VIRECHANA KARMA WITH TRIVRITADI KWATH AND SHAMAN CHIKITSA WITH AVIPATIKARA CHURNA IN THE MANAGEMENT OF URODAHA (RETROSTERNAL BURNING) IN AMLAPITTA (ACID PEPTIC DISORDER)

In the recent years there has been an unprecedented increase in the incidence of Gastrointestinal System disorders due to change in lifestyle, diet pattern, behavioral pattern, mental stress and also hazardous use of painkillers. Ayurveda comes with varieties of treatment options to cure the GI disorders without causing any harmful effect. The aim of this study is to compare between Shodhan and Shaman therapy in Amlapitta, to evaluate the efficacy of Virechana Karma and Shaman Chikitsa. The criterions of diagnosis of patients was based on sign and symptoms of Amlapitta and Ayurvedic and modern text. Two groups were taken, and duration of study was of one month. In group A, virechana therapy was given with Trivritadi Kwath, and in group B, shaman therapy was given with Avipatikara churna. Follow up of patients was done after given therapy. Result shows that shodhana therapy is more effective than shaman therapy in patients of Amlapitta.