Moringa oleifera decrease blood sugar level and blood pressure in pregnant diabetic rats

2021 ◽  
Vol 11 (2) ◽  
pp. 88-91
Author(s):  
Harry Kurniawan Gondo
Keyword(s):  
Blood Pressure ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Moringa Oleifera ◽  
Diabetic Rats ◽  
Pregnant Diabetic

scholarly journals Effect of nicorandil, on blood glucose level in alloxan induced diabetic rats and its pharmacodynamic interaction with glibenclamide

2018 ◽  
Vol 7 (12) ◽  
pp. 2378
Author(s):  
Soni .
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Potassium Channel ◽  
Blood Sugar ◽  
Glucose Level ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
Potassium Channel Opener ◽  
Pharmacodynamic Interaction

Background: Diabetes increases the risk of macrovascular complications and is often associated with angina in patient. Currently nicorandil, a potassium channel opener is being frequently used for the prevention and long-term treatment of angina pectoris. Glibenclamide exerts its antidiabetic action by closing the ATP sensitive potassium channels. Simultaneous use of nicorandil may antagonizes this action and may worsens the existing diabetes. To evaluate the pharmacodynamic interaction present study has been taken to study the effect of Nicorandil, a potassium channel opener on blood glucose level of alloxan induced diabetic rats and its pharmacodynamics interaction with Glibenclamide.Methods: Albino rats, weighing 150-200gm of male sex were used for the study. Diabetes was induced by injecting alloxan monohydrate 2% solution intra peritoneally in a dose of 150mg/kg body weight. Animal with Fasting Blood Sugar level between 250-300g/dl was selected for study and they were divided into 4 groups of 5 animals each. Group I- serving as control received 0.5ml normal saline orally for 28 days. Group II was given glibenclamide (0.5mg/kg body wt) for 28 days. Group III was treated orally with nicorandil (0.3mg/kg body wt) for 28 days. Group IV was given glibenclamide (0.5mg/kg) and nicorandil (0.3mg/kg) for 28 days. Fasting Blood Sugar level was recorded in all rats on 1st,3rd,7th,14th,21st and 28th day of the treatments.Results: results showed that glibenclamide significantly reduce blood sugar level (p <0.05) Wherase nicorandil showed rise in blood glucose level (p <0.05) While the combination (glibenclamide + nicorandil) showed rise in blood glucose (p <0.05) overall.Conclusions: Nicorandil worsen the existing diabetes and to be avoided or replaced with alternative drug in case of diabetes being treated with sulfonyl urease group of drugs.

Glucose Uptake by Isolated Normal and Diabetic Rat Lenses

1956 ◽  
Vol 186 (3) ◽  
pp. 406-408 ◽  
Author(s):  
M. Neil Macintyre ◽  
Sarah S. Polt ◽  
John W. Patterson
Keyword(s):  
Glucose Uptake ◽  
Blood Sugar ◽  
Incubation Medium ◽  
Blood Sugar Level ◽  
Intraperitoneal Administration ◽  
Diabetic Rats ◽  
Diabetic Rat

The uptake of glucose by isolated lenses from normal and diabetic rats has been measured and found to average 1.1 and 0.5 mg of glucose/gm of lens/hr., respectively. The uptake is not affected by fasting the rats or by the addition of insulin to the incubation medium. The injection of insulin 2 hours before killing increases the uptake of normal lenses to 1.4 mg of glucose/gm of lens/hr. The same result is obtained if the blood sugar level of the insulin injected animal is maintained by intraperitoneal administration of glucose.

scholarly journals Intervensi Keperawatan pada Pasien Terkonfirmasi COVID-19 dengan Komorbid DM Tipe 2 dan Hipertensi: Studi Kasus

2021 ◽  
Vol 16 (2) ◽  
pp. 126-137
Author(s):  
Alif Khanifudin ◽  
Arifin Triyanto ◽  
Dwi Asih Rohmawati
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Data Collection ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Oxygen Therapy ◽  
Health Workers ◽  
Anxiety Reduction ◽  
High Morbidity

Comorbidities in COVID-19 patients with the highest percentage are hypertension and diabetes mellitus. Patients with comorbid hypertension and DM have high morbidity and mortality. This study aims to determine the interventions in COVID-19 patients with comorbid DM and hypertension. The method used is a case study with data collection through patient and family interviews, medical record studies and direct observation or through CCTV. The studies showed that the patient was diagnosed with severe COVID-19 by  oxygen therapy (NRM 15 L/min), treating COVID-19 and managing comorbid hypertension and DM with medication and monitoring and reducing anxiety. During treatment, the patient was desaturated, blood pressure and blood sugar level had not been controlled, and the anxiety was quite high. It can be said that interventions that can be given to COVID-19 patients with comorbid hypertension and DM are oxygen therapy, medication, anxiety reduction, and comorbid management. Comorbid hypertension and DM were controlled with medication and regular monitoring. the patient's blood pressure and blood sugar level had not been controlled, it is possible that the patient's anxiety is still experienced. So that as health workers in providing care are expected to pay attention to the biopsychosociospiritual aspects so that the patient's problems are resolved.

Modulatory Effect of Whole Flour and Hydroalcoholic Extract of Finger Millet (Elusine coracana) on the Abnormalities Associated with Metabolic Syndrome in Hyperlipidemic Diabetic Rats

2021 ◽  
Vol 1 (30) ◽  
pp. 39-48
Author(s):  
Upma Bhandari *Mamta F Singh
Keyword(s):  
Metabolic Syndrome ◽  
Body Weight ◽  
Blood Sugar ◽  
High Fat Diet ◽  
Blood Sugar Level ◽  
Finger Millet ◽  
Diabetic Rats ◽  
Fasting Blood Sugar ◽  
High Fat ◽  
Hydroalcoholic Extract

Abstract- The present study was designed to evaluate the effect of whole flour and hydroalcoholic extract of finger millet (Elusine coracana) in high fat diet (HFD) and streptozotocin induced metabolic syndrome in rats. The HFD was fed to the rats for a period of 45 days to induce hyperlipidemia. Diabetes was induced by single intraperitoneal injection of streptozotocin (65mg/kg i.p) in 0.1M citrate buffer pH 4.5. Animals with fasting blood sugar level of 250 mg/dl were considered as hyperlipidemic diabetic rats (HDR) and were selected for the study. The HDR were divided into five groups with six animals in each group and one group of normal animals. The HDR received whole flour and hydroalcoholic extract of Elusine coracana at a dose of 100, 200 and 400 mg/kg for a period of 21 days. Body weight, body mass index, fasting blood sugar level, lipid profile and the level of oxidative stress was measured in animals after the treatment. All treatments significantly decreased body weight, BMI, fasting blood sugar and also improved lipid profile in HDR as compared to the toxicant control. The treatments significantly reduced the level of lipid peroxidation and improved superoxide dismutase and reduced glutathione in the pancreas of HDR. Whole flour and hydroalcoholic extract of Elusine coracana at a dose of 200 and 400 mg/kg caused significant alleviation of the abnormalities of metabolic syndrome in rats. Keywords: Finger millet, High fat diet, Hyperlipidemic diabetic rats, Metabolic syndrome.

scholarly journals Beneficial Effects of Soygurt Intake in Type 2 Diabetes Mellitus in Animal Model Rat (Rattus Norvegitus)

2020 ◽  
Vol 1 (1) ◽  
Author(s):  
Ni Wayan Desi Bintari ◽  
Putu Ayu Parwati
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Weight ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Diabetic Rats ◽  
Male Rats ◽  
Probiotic Food

Type 2 Diabetes Mellitus (T2DM) is the more common type of diabetes results from the ineffective use of insulin. Improvement of the metabolic system in T2DM patients can be done through the regulation of gut microbiota balance. Gut microbial improvement can be modulated directly by probiotic food consumption. Soygurt is probiotic food with a low glycemic index (GI) and glycemic load (GL) value and rich in isoflavones, which has a potential effect in reducing diabetes risk. The aim of this study is to determine the effect of soygurt consumption in blood glucose levels and body weight of albino wistar rats (Rattus norvegitus). Reseach using a completely randomized design for experimental study. Subjects of this research are 30 male rats (R. norvegistus) aged 2-3 months with average body weight 150-200 gr. Diabetic rats were induced by using single intraperitoneal injection (175 mg/kg BW) alloxan monohydrate. Soygurt feeding given once daily using oral gavage feeding. The result showed that soygurt feeding in diabetic rats with three variations of treatment could significantly (p<0,05), lowering blood sugar level and improve body weight after 28 days of treatment. Treatment of 4ml/day soygurt has the highest effect in lowering blood sugar level and improving body weight, followed by treatment of 3ml/day and 2ml/day soygurt.

Benefit effect of ethanolic extract of Bay leaves (Laura nobilis) on blood sugar level in adult diabetic rats induced by alloxan monohydrate

2020 ◽  
Vol 23 (16) ◽  
Author(s):  
Salah M.M. Al Chalabi ◽  
Duha Mysire Majeed ◽  
Ahmed Abdulmunem Jasim ◽  
Khalid Suhail Al-Azzawi
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Alloxan Monohydrate

Pancreatic beta-cell regeneration

1988 ◽  
Vol 77 (03) ◽  
pp. 147-151 ◽  
Author(s):  
D.P. Rastogi ◽  
A.C. Saxena ◽  
Sunil Kumar
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Pancreatic Beta Cell ◽  
Diabetic Rats ◽  
Alcoholic Extract ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Treatment Of Diabetes ◽  
Wild Variety ◽  
Histopathological Studies

Abstract Cephalendra, indica ∅ (41% v/v alcoholic extract of the wild variety of Cephalendra indica Naud.), on regular administration in doses ranging from 25 μml to 75 μml/100 g of body weight (gbw) by the oral or intraperitoneal (ip) route produced a significant fall in blood sugar level in alloxan-induced diabetic rats. Biochemical studies showed stabilization of blood sugar level in 70% of cases of fourteen to twenty days after withdrawal of the drug. Histopathological studies revealed regeneration of pancreatic β cells. The hypothesis is that the drug acts through the hypothalamo-hypophysial-pancreatic axis, producing selective regeneration of β cells. The drug may indirectly release inhibitory factors from hypothalamic neurons, inhibiting the secretion of growth hormone and triggering insulin secretion from β cells. The therapeutic action of the drug on pancreatic β cells and lack of acute and subacute toxicity may open up new prospects in the treatment of diabetes mellitus.

Alloxan-diabetic rats during acclimation to cold

1963 ◽  
Vol 205 (1) ◽  
pp. 184-188 ◽  
Author(s):  
Robert H. Poe ◽  
Joseph W. White ◽  
Thomas R. A. Davis
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Survival Rate ◽  
Insulin Sensitivity ◽  
Blood Sugar ◽  
Cold Exposure ◽  
Muscle Glycogen ◽  
Blood Sugar Level ◽  
Quantitative Relationship ◽  
Diabetic Rats

The survival rate of alloxan-diabetic rats at 5 C was found to be related to the pre-exposure nonfasting blood sugar level. The majority of deaths occurred within the first 2 weeks of cold. Once cold acclimation had been accomplished, the survival rate was 100%. A significant decrease in skeletal muscle glycogen, and the highest percentage of weight loss were found after 2 weeks of cold exposure. A quantitative relationship between survival in the cold and available insulin is suggested. An augmented ability to utilize carbohydrate, related in part to an increased insulin sensitivity, is hypothesized to account for the postacclimation findings.

Sign in / Sign up

Export Citation Format

Share Document