Game-Centred Study Using Eigenvector Centrality in High-Level Women’s Volleyball: Play Efficacy is Independent of Game Patterns… Or is it?

In sports, it is often assumed that distinct game patterns may influence the outcome of the play differently. However, a few articles about men’s volleyball have suggested that play efficacy may rely more on the quality of individual attack actions, and not on game patterns. Therefore, the goal of this paper was to scrutinize if and how game patterns influence play efficacy in high-level women’s volleyball. Eigenvector Centrality was assessed to integrate direct and indirect relationships between games actions. Thirteen matches from the women’s World Grand Prix’2015 were analysed (46 sets; 2,016 plays). Actions were categorized according to game complex (K0 to KV) and three levels of the efficacy of each play: error, continuity, and point. The results showed that play efficacy was independent of game patterns (the central pattern was non-ideal setting conditions in all complexes and preference for using slow attacks in the extremities of the net). There were, however, some regularities for each game complex. For example, while in KI to KIII, Zone 4 was the most used attack zone, in KIV and KV there was a complete inversion to Zone 2. Moreover, results revealed that women’s volleyball games are more predictable in relation to the play space (attack zones) while increasing the risk through enhanced game speed (attack tempo), in comparison with what studies in men’s volleyball have shown. Future studies should consider situational variables (e.g., match status, home vs away matches), and individual players’ actions should be considered in order to understand their relationships with team patterns better.

A case of complete inversion of the uterus after childbirth

On December 19, 1894, sick Eleanor M ko, diagnosed with polypus uteri, was sent to me by a comrade of the land. Arriving to the patient at the hotel, I found her in a very bad state: deathly pale, with a very weak pulse, with t to 40.0 ; dirty blood with a strongly putrid odor was discharged from the vagina. The patient was immediately sent to the hospital, where a thorough examination gave the following: the patient is of medium height, the skeletal system is developed correctly, muscles and skin are flabby; the outer covers are very pale; the visible mucous membranes are very pale with a cyanotic tinge; heart, lungs, and urine are normal. External genitals, heavily soiled with a dirty red fluid, are normal; first degree perineal rupture; the genital gap gapes a little; 2 snt. from the entrance to the vagina, the finger comes across a round, rather soft and elastic body, reminiscent, at first impression, of a fibrous polyp; this body, the size of a slightly enlarged uterus, has only a round outline below; above it tapers and passes into a small groove, limited by the external os of the uterus. In place of the body of the uterus, a small solid formation is felt, the size of a slightly enlarged ovary; this formation closes a funnel, which in this case cannot be felt; nothing pathological is felt in the vaults. When viewed in mirrors, the described body appears to be a dirty gray color, in places even completely black; at the slightest touch, the body bleeds quite a lot. The patient's body temperature is 39.6 C., pulse 120, very weak and easily compressed; the patient cannot move without assistance.

Cremmelin. A case of complete inversion of the uterus, or invesion of the third degree. (Austr. Med. Gaz. May, 1892). A case of complete inversion of the uterus or third degree eversion.

Mrs. N., 33 years old, multipara; 13 Feb urgent labor; as the last was tightly fastened, the uneducated midwife began to pull the umbilical cord, all through which there was an inversion, which passed unnoticed at first. But. when on the next day the woman in labor, who had not urinated for a whole day, got up for this purpose from the bed, a prolapse of the uterus occurred. The author, invited Feb 15 found the uterus protruding from the genital gap by 6-8 inches, partial vaginal inversion, easy bleeding, frequent pulse, severe abdominal pain.

Evolution-guided engineering of small-molecule biosensors

Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection and regulation of cellular metabolism. However, both the biosensor specificity and the correlation between ligand concentration and biosensor output signal, also known as the transfer function, often needs to be optimized before meeting application needs. Here, we present a versatile and high-throughput method to evolve and functionalize prokaryotic aTF specificity and transfer functions in a eukaryote chassis, namely baker’s yeastSaccharomyces cerevisiae. From a single round of directed evolution of the effector-binding domain (EBD) coupled with various toggled selection regimes, we robustly select aTF variants of thecis, cis-muconic acid-inducible transcription factor BenM evolved for change in ligand specificity, increased dynamic output range, shifts in operational range, and a complete inversion of function from activation to repression. Importantly, by targeting only the EBD, the evolved biosensors display DNA-binding affinities similar to BenM, and are functional when ported back into a non-native prokaryote chassis. The developed platform technology thus leverages aTF evolvability for the development of new host-agnostic biosensors with user-defined small-molecule specificities and transfer functions.

Peculiarities of energy production in glial cells of sympathetic ganglia

Aim. To determine the energy profile of satellite gliocytes in the cranial cervical sympathe-tic ganglia (CCSG) in normal functioning of nicotinic cholinergic synapses (nChS) and in their pharmaceutical deprivation. Materials and Methods. Deprivation of CCSG in rabbits was implemented by using cholinolytic dimecolinum. The activity of H- and M-isoforms of lactate de-hydrogenase (LDH) was determined in gliocytes offrozen sections by integral cytophotomentry using Brumberg and Pevzner method. Results. In satellite gliocytes a considerably higher activity of M-isoforms of LDH in comparison with that of H-isoforms was found which evidences predomination of anaerobic mechanisms of energy metabolism over aerobic ones in the studied cells. The relationship between the levels of activity of (Н/М) isoforms of LDH in gliocytes with experimental deprivation of nChR exhibited a complete inversion as compared to glial cells of CCSG with normal functioning of synapses. Conclusion. Satellite gliocytes of cranial cervical sympathetic ganglion, like any other somatic cells, possess initially programmed aerobic system of energy production which transforms into anaerobic system under influence of impulses arriving through nicotine-sensitive cholinergic synapses.

Nonno e Arato: alcune proposte = Nono y Arato: algunas propuestas = Nonnus and Aratus: some proposals

Il presente articolo si propone di indagare il rapporto che Nonno intrattiene nelle Dionisiache con Arato, uno dei suoi molteplici modelli. Lo studio prende in analisi quattro passi significativi (1, 163-175; 25, 123-133; 38, 354-371; 47, 448-452) e li pone a confronto con i relativi versi dei Fenomeni e con il poema arateo nel suo complesso. Sarà messo in luce il duplice atteggiamento di semplice imitatio cum variatione/totale rovesciamento in cui si esplica la sfida ingaggiata dal Panopolitano. Il poeta, descrivendo le immobili costellazioni aratee come creature reali, giunge a superare il predecessore tramite un mimetismo sempre più esasperato, fino a dare vita a un'astronomia "dionisiaca", consona sia alle proprie tendenze stilistiche (paradosso) sia ai motivi portanti della propria opera (rapporto tra originale e copia). Questa astronomia personale prende forma nella Corona di Arianna, simbolo dell'unità cui, in un'ottica ispirata al Neoplatonismo, la ποικιλία finisce per tornare.El presente artículo pretende investigar la relación entre Nono y Arato, uno de sus muchos modelos, en las Dionisíacas. El estudio examina cuatro pasajes significativos (1, 163-175; 25, 125-133; 38, 354-371; 47, 448-452) y los compara con los relacionados versos de los Fenómenos y el poema arateo en su conjunto. Se destacará la actitud dual de sencilla imitatio cum variatione/total derrocamiento en la que se manifiesta el reto lanzado por Nono. El poeta, describiendo las inmóviles constelaciones arateas como criaturas reales, llega a superar su predecesor por medio de un mimetismo cada vez más acentuado, hasta crear una astronomía "dionisíaca", apropiada tanto para sus tendencias estilísticas (e. g. paradoja) como para los principales motivos de su obra, es decir la relación entre original y copia. Esta astronomía personal toma forma en la Corona de Ariadne, símbolo de la unidad a la cual, en una perspectiva inspirada en el Neoplatonismo, la ποικιλία tiene que volver.The aim of this paper is to investigate the relationship between Nonnus and one of his many models, Aratus, in the Dionysiaca. The study examines four significant passages (1, 163-175; 25, 125-133; 38, 354-371; 47, 448-452) and compares them with related verses of the Phaenomena and the aratean poem as a whole. The dual attitude, i. e. bare imitatio cum variatione/complete inversion, the Panopolitan shows in his competition with the predecessor will thus be highlighted. Describing the fixed aratean constellations as real creatures, the poet finally overcomes his model through an increasingly enphasized mimetism whose main outcome is a novel and authentic "dionysiac" astronomy: appropriate both to his own stylistic devices (e. g. paradox) and to the underpinning themes of his work, namely the relationship between original and copy. This personal astronomy finds expression in Ariadne's Crown, a symbol of unity to which, in a Neoplatonism-inspired perspective, ποικιλία is meant to go back.

A Direct Approach to Enantiopure Propionate Derivatives from Ethyl Lactate

The S-propargyl xanthate derived from ethyl (S)-lactate reacts upon heating with various acidic substances to give the propionate transfer product in high yield and with complete inversion of configuration.

OVID'S HERMIONE: A KALEIDOSCOPIC HEROINE

Critics generally have not warmed to Heroides 8 (in which Hermione appeals to her husband, Orestes, to rescue her from Pyrrhus, who has claimed her as his promised bride, carried her off, and holds her prisoner). Jacobson opined that the poem is ‘not very successful’ and claimed that the lengthy argumentation is ‘rather boring, not to say sometimes silly and annoying’, while Palmer described it as ‘the feeblest and least poetical of all the Heroides’. However, scholars have largely neglected some typically Ovidian cleverness and complexity in kaleidoscopic play with character. Ovid's Hermione is Hermione, but she also takes on the guise of other mythological heroines, and she represents a complete inversion of an earlier depiction of Hermione. All of this gives the poem a distinct intellectual appeal to supplement the emotional impact, with witty touches to ensure that the epistle is not mawkish.