Possibilities of using neodymium laser to improve the condition of vaginal mucosa in women of various ages with initial stages of genital prolapse

Genital prolapse is a sort of epidemic and is registered today in 30% to 56% of women of both reproductive and menopausal ages. Until now, the initial stages of prolapse were not taken into account; as a rule, the correction began immediately with surgical treatment, the results of which were not always satisfactory, and the recurrence rate with plastic correction with one’s own tissues ranged from 37 to 45%. One of the main manifestations of prolapse of the vaginal walls, especially n perimenopause, is vulvovaginal mucosal atrophy, which directly depends on the pH in the vagina. The study is devoted to the analysis of the effectiveness of using neodymium laser to improve the condition of the vaginal mucosa in women of different age groups with initial degrees of genital prolapse. Purpose: scientific substantiation of using neodymium laser in patients of different age groups with grade I–II cysto-rectocele. Material and research methods. Studies were carried out in 69 women aged 31 to 52 years with cysto-rectocele of grade I–II (ICD-10 code N81.6), with the duration of the disease from 4 to 15 years. All patients, depending on their age and the method of treatment used, were divided into 2 groups comparable in terms of clinical and functional characteristics — the main and control groups, each of which had 2 subgroups. In the main group: subgroup 1 included 27 patients of reproductive age with grade I–II cysto-rectocele, who underwent a neodymium laser course with Magic Gyno, consisting of 3 intravaginal procedures with an interval of 28 days; subgroup 2 included 22 patients of perimenopausal and menopausal age with grade I–II cysto-rectocele, who underwent a course of 3 intravaginal procedures with Magic Gyno neodymium laser with an interval of 28 days. The control group included 20 patients with grade I–II cysto-rectocele, who underwent a special complex of exercise therapy; depending on their age, they were also divided into two subgroups: 1 (10 patients) — of reproductive age, 2 (10 patients) — of perimenopausal and menopausal age. The results obtained indicate a pronounced effect of the course application of intravaginal exposure by a neodymium laser on the state of the vulvovaginal mucosa in patients with grade I–II cysto-rectocele, of both reproductive and, most importantly, peri-menopausal age, which was manifested in the normalization of the pH of vaginal discharge and elimination of signs of atrophy of the mucous membrane of the vulva and vagina and was confirmed by the data of pH-metry and the Vaginal Health Index Score. Conclusion. The course use of a neodymium laser in patients of different age groups with grade I–II cysto-rectocele contributes to the formation of a pronounced tropho-stimulating effect, which is manifested in the normalization of the pH of the vaginal discharge and the elimination of signs of atrophy of the mucous membrane of the vulva and vagina.

An Optimal Geometry Configuration Algorithm of Hybrid Semi-Passive Location System Based on Mayfly Optimization Algorithm

In view of the demand of location awareness in a special complex environment, for an unmanned aerial vehicle (UAV) airborne multi base-station semi-passive positioning system, the hybrid positioning solutions and optimized site layout in the positioning system can effectively improve the positioning accuracy for a specific region. In this paper, the geometric dilution of precision (GDOP) formula of a time difference of arrival (TDOA) and angles of arrival (AOA) hybrid location algorithm is deduced. Mayfly optimization algorithm (MOA) which is a new swarm intelligence optimization algorithm is introduced, and a method to find the optimal station of the UAV airborne multiple base station’s semi-passive positioning system using MOA is proposed. The simulation and analysis of the optimization of the different number of base stations, compared with other station layout methods, such as particle swarm optimization (PSO), genetic algorithm (GA), and artificial bee colony (ABC) algorithm. MOA is less likely to fall into local optimum, and the error of regional target positioning is reduced. By simulating the deployment of four base stations and five base stations in various situations, MOA can achieve a better deployment effect. The dynamic station configuration capability of the multi-station semi-passive positioning system has been improved with the UAV.

Vestibular Rehabilitatiоn in Vestibular Migraine

The search for possible ways to minimize dizziness in patients with vestibular migraine is especially relevant in the aspect of individualized complex vestibular rehabilitation. Aim. To study the possibilities of complex individualized vestibular rehabilitation in patients with vestibular migraine. Material and methods. The study included 122 patients (40 men and 82 women) aged 18 to 50 years, with significant vestibular migraine. We used the Dizziness Handicap Inventory scale for assessing dizziness and a 5-point Scale for subjective assessment of the severity of dizziness and a special complex method including a set of vestibular exercises, a method of the computer stabilometry with biofeedback. Objective control of vestibular rehabilitation was carried out with the help of stabilometric testing. Results and discussion. Positive dynamics were observed when analyzing the data of the physical, functional and emotional subscales of the Dizziness Handicap Inventory and the Scale of Subjective Assessment of the Dizziness Severity. In addition, the presented stabilometric diagnostics made it possible to fix the difference between the initial condition of patients with vestibular dysfunction and after 3 months of the special vestibular rehabilitation.Тhere was a statistically significant decrease in the basic stabilometric parameters: the area of the statokinesiogram (median area, mm² – 254 (95% CI 222-285)) and the rate of deviation of the center of pressure (median speed, mm/s – 21 (95% CI 17-24)) as well as a decrease in the shifts of the spectrum energy in the low-frequency and high-frequency spectrum that indicates an improvement in stability. The presented method for influencing the compensatorycapabilities of regulatory mechanisms in patients with vestibular migraine positively affects the efficiency of the equilibrium system as a whole, optimizing postural stability in this category of patients. Conclusion. An individually selected comprehensive program of vestibular gymnastics and hardware rehabilitation techniques on the stabilographic platform with biofeedback helps to improve postural stability and minimize dizziness in patients with vestibular migraine.

Circumstantial determinants in the structure of a complex sentencein modern French

Рассмотрены некоторые особенности функционирования обстоятельственного детерминанта в структуре сложноподчиненного предложения. Теоретическая значимость определяется в поле конструктивного синтаксиса и выявления наиболее устойчивых и частотных признаков функционирования различных структурных компонентов предложения. В результате компонентного анализа намечены основные параметры систематизации особенностей функционирования детерминирующих компонентов в структуре сложного предложения, что формирует практическую значимость проведенного исследования при работе с текстами. Исследование строилось на проведении анализа конструктивных показателей полипредикативных конструкций, связанных характером включения детерминантов в структуру предложения. В результате выявлена специфика семантико-синтаксического взаимодействия детерминанта со структурными компонентами сложного предложения, определены условия, которые могут влиять на типологические свойства при образовании особых сложноподчиненных конструкций. Some peculiarities of functioning of a circumstantial determinant in the structure of a complex sentence are considered. The theoretical significance is determined in the field of constructive syntax and the identification of the most stable and frequency signs of the functioning of various structural components of the sentence. The component analysis made it possible to outline the main parameters of the systematization of the features of the functioning of the determinant components in the structure of the complex sentence, which form the practical significance of the study when working with texts. The study was based on analysis of structural indices of polypredicative constructions related to the nature of inclusion of determinants in the sentence structure. As a result, the specifics of the semantic-syntactic interaction of the determinant with the structural components of the complex sentence were revealed, the conditions that can affect typological properties in the formation of special complex structures have been identified.

Modified nonlinear Schrödinger models, 𝒞𝒫s𝒯d invariant N-bright solitons and infinite towers of anomalous charges

Modifications of the nonlinear Schrödinger (MNLS) model [Formula: see text] where [Formula: see text] and [Formula: see text], are considered. We show that the MNLS models possess infinite towers of quasi-conservation laws for soliton-type configurations with a special complex conjugation, shifted parity and delayed time reversion ([Formula: see text]) symmetry. Infinite towers of anomalous charges appear even in the standard NLS model for [Formula: see text] invariant [Formula: see text]-bright solitons. The true conserved charges emerge through some kind of anomaly cancellation mechanism. Our analytical results are supported by numerical simulations of two-bright-soliton scatterings with potential [Formula: see text]. Our numerical simulations show the elastic scattering of bright solitons for a wide range of values of the set [Formula: see text] and a variety of amplitudes and relative velocities. The MNLS-type systems are quite ubiquitous, and so, our results may find potential applications in several areas of nonlinear physics, such as Bose–Einstein condensation, superconductivity, soliton turbulence and the triality among gauge theories, integrable models and gravity theories.

A New Generalized Variance Approach for Measuring Multidimensional Inequality and Poverty

The paper suggests a new generalized variance concept for measuring multidimensional inequality of a stratified society, based on multivariate statistical methods, where the members of society form a cloud in the oblique space of dimensions of inequality, such as income, expenditure and property. The cloud presents the multidimensional inequality capsulized in the cloud. The goal is to condense all the inequality information embodied by the cloud into a composite compact metric characterizing both the shape and the inner structure of the cloud. Contrary to the conventional literature that considers multidimensionality as a unidimensional weighted combination of the dimensions, our new composite index measures the inequality of the configuration of the points in the cloud. Our aim is twofold. First, we introduce the Inequality Covariance Matrix (ICM) assigned to the cloud, with elements measuring the correlations among dimensions. Having ICM, we propose the Generalized Variance (GV) of ICM to measure the composite Generalized Variance Inequality (GVI) level. Second, to evaluate the stratum-specific structure of the overall inequality, we suggest a new two-stage procedure. In the first stage, we divide the total GVI into between-groups and within-groups effects. Then, in the second stage the contributions of the strata to the within-groups inequality and, the contributions of the dimensions to the between-groups inequality are calculated. This GVI approach is sensitive to the correlation system, decomposable into stratum effects and, the number of dimensions is not limited. Moreover, including the log-dimensions in the analysis, GVI yields an Entropy Covariance Matrix giving a new Generalized Variance Entropy index. Finally, the GVI of censored poverty indicators means multidimensional poverty measurement. This special complex task is not yet solved in the traditional literature so far.

Modern view of speech readiness for school of children of older preschool age with typical psychophysical development and speech disorders

A theoretical review of modern scientific sources on the problem of "speech readiness" for the schooling of older preschool children with typical psychophysical development and speech disorders is presented. The aim of research: analysis of modern research on speech readiness for the schooling of older preschool children with typical and speech disorders. The objective of research was to substantiate scientific sources on the study of the terms "speech readiness" and "speech preparation" for school in older preschoolers; determination of components of speech readiness of children of older preschool age with speech disorders. It is established that there are different views on the definition of the terms "speech readiness" and "speech training". Speech readiness for the school includes children's mastery of grammatical, lexical norms of speech, enriched vocabulary, use in educational and everyday activities of various functions of speech; it is determined that speech readiness contributes to the process of speech preparation of the future student to master the school curriculum. Speech training involves general and special training. It was determined that the formation of basic intellectual, semiotic and regulatory components is necessary for the speech readiness of children with speech disorders, which are formed under the influence of a special complex of correctional and developmental speech therapy work. Based on the analysis of scientific sources, the components of speech readiness for the schooling of older preschool children with speech disorders were identified: cognitive is about understanding of the semantic constructions of language and speech; motivational is about understanding of social and cognitive motives of learning; the component of activity - active participation in various types of speech activity; emotional - verbalization of emotions and feelings

A Case Study of Cyclic Top Coal Weakening Process Based on Highly Tough Coal Seam with Partings

The top coal weakening process is an effective mean to increase the coal output, reduce the coal resource waste, and promote the sustainable development in a mine. The conventional blast weakening process and water injection weakening process are more widely applied in fully mechanized caving mining of hard thick coal seams, but under some special complex geological conditions, no desirable performance has been achieved in top coal weakening by one weakening process alone after substantial investment in capital and equipment. In the context of highly tough top coal with partings at working face 110501 for fully mechanized top coal caving mining in Yushutian Coal Mine, effects of parting band and high toughness on top coal breaking were studied in terms of mechanism and extent, a multifunctional compound drilling field integrating blast weakening, water injection weakening, and gas extraction was purposefully designed, and a cyclic top coal weakening process for highly tough coal seams with partings was proposed. Engineering practice and performance testing show that degree of fragmentation and mobility of top coal was improved, mean top coal recovery ratio at the working face increased by about 35%, coal resource waste decreased, and potential risks of gas explosion and mine fire were eliminated, which provides reference for top coal weakening process under similarly complex engineering conditions.

Approaches to the analysis and synthesis of unmanned aircraft system in the research task of aerial survey of area object

The presented research was performed to develop a scientific and methodological apparatus for estimation of aerial survey effectiveness. The work takes into account the parameters of the unmanned aerial vehicle, of the optoelectronic onboard special complex and the spatial properties of the areal object. The result of the research of works in the field of aerial survey using unmanned aerial systems is presented. It is revealed that the analysis and synthesis of specific sets of unmanned aerial vehicles with onboard special complexes is carried out in a qualitative way according to individual technical parameters. At the same time, aggregate indicators characterizing aerial survey effectiveness are not evaluated. Models of an unmanned aerial vehicle, special airborne complex, areal object and requirements for the quality of survey materials are proposed. The assumptions under which the modeling of aerial survey of the areal object is performed are determined. On the basis of models the procedures of analysis and synthesis of aerial survey system are developed. The content of the procedures takes into account the loss of the survey resource that occurs due to the remoteness of the object and making approaches to the next shooting route in tack flight mode. The procedures allow to determine the potential effectiveness of the survey and to choose the configuration of the onboard special complex to ensure optimal performance of the survey of the areal object. The results of a computational experiment on the example of a conditionally real light high-altitude unmanned aerial vehicle are presented. The dependence of the effectiveness of aerial photography on the remoteness and spatial properties of the areal object is presented. For different conditions, the configuration of the onboard special complex, which provide optimal multi-route shooting, is determined.

MICROBIOLOGICAL METHODS FOR DETERMINING RESIDUAL QUANTITIES OF ANTIBIOTICS IN MEAT AND MEAT PRODUCTS

Antibiotics are used not only for treating animals, but also to stimulate growth, fattening, and increase their productivity. When such drugs enter the human body with meat products, resistance, dysbiosis, etc. develops. It is very important to have methods available to control each carcass. The article discusses the microbiological methods used on the territory of the Russian Federation. They are highly sensitive, while at the same time they are not very specific. Some of them can be attributed to express methods, since the analysis time is 3-4 hours. These methods do not require any special complex equipment and can be used in any veterinary laboratory.