An estimation of the seismic risk in Castilla - La Mancha (Spain) is set forth in the current work, in order to develop the special emergency programme. To carry out the study it has been necessary to define a multidisciplinary group of experts in each involved discipline: geology and tectonics, seismology, architecture, engineering and geographical information systems. The main aim is to develop different seismic risk maps to provide the basis to elaborate the emergency plans in Castilla - La Mancha. These plans must follow the stipulated guidelines in the seismic risk field. A probabilistic methodology is adopted to define the seismic risk, considering this as the human and material losses in presence of the expected seismic event. The seismic hazard of the area of study is evaluated through return periods of 475 and 975 years, equivalents to exceedance probabilities of 10% and 5% in 50 years respectively. These probabilities are proposed in the framework of the Spanish seismic code “Normativa Sismorresistente Española, NCSE-02”, for conventional and special buildings. In a first approach, the study attempt to estimates the expected losses in each city of the overall of Castilla - La Mancha in the presence of the probable movements in 50 and 100 years. The results allow us to make a relative estimation of the seismic risk in different areas, identify those cities which undergo highest damages indexes and which ones would require a more in-depth assessment so as to mitigate the risk. Besides, the results contribute to establish objective priorities to define emergency plans at city scale.http://dx.doi.org/10.4995/CIGeo2017.2017.6670