Academic women leaders are teaching, conducting research, running departments, making policies, and overseeing their faculty and students, all while taking responsibility for their own homes, families, and children, and doing it all under one roof. Motherscholars (i.e., academic mothers who accepted administrative and/or leadership positions in higher education) have a particular story to tell during this pandemic. This chapter will highlight the issues confronting these MotherLeaders and illustrate how institutional gender inequities and societally imposed responsibilities in the home, and with children, impact women's ability to lead in colleges and universities during the COVID-19 pandemic.