Disparities in healthcare limit accessibility to care among affected populations and can include imbalances in the equitable achievement of optimal health. These imbalances occur as a result of differences that others have in financial means, education, culture, age, race, gender, sex, ethnicity, and religion. Consequentially, as health disparities persist among populations, mortality and morbidity rates reflect these inequities in health care. Hence, human life is quantified by geographic location, skin color, language, poverty, and an inability to culturally assimilate with majority populations. Hidden biases overshadow the pricelessness of human life, disease management, and disease prevention. Chapter 1 provides an overview of what encompasses health disparities and how equity is involved. Vulnerable populations within the United States are examined, and hidden biases are discussed as factors that impact the achievement of equitable healthcare.