Decades ago, researchers thought about 21st century learning and created different frameworks. The frameworks were similar and refocused learning from low-level skills to higher cognitive strategies. These frameworks called for thinking, working together, finding information, and problem solving. One popular framework, the Four Cs model, included critical thinking, communication, collaboration, and creativity, which the National Association of Education promoted. The Four Cs framework became popular at the same time Common Core State Standards were distributed. Districts and schools incorporated the Four Cs framework with the Common Core State Standards. Implicit in the Four Cs model is the integration of technology. Over time, the Four Cs was expanded to include social and emotional learning. The insight from the research helps educators to construct a holistic framework. This chapter gives historical background, defines terms, explains a new model called Four Cs Plus SEL, and suggests future research directions.