This chapter addresses several key background topics, including the range and types of psychological dysfunctions, the scope of the problems in terms of incidence and prevalence of cases, and the burdens these place on individuals, families, and society at large. The chapter conveys core features of the mental health crisis and why innovation in developing remedies is so critical. The aim of the chapter is to establish the need for more effective interventions in light of the range of dysfunctions, the high number of people who experience them, and the burdens these dysfunctions cause. The burdens can be evaluated in many ways, including measures of impairment, costs, disability, and lost days. Overall, the costs and lost days of adequate functioning and lost days of life are enormous as a result of mental illness.