Skin lesions suspected to be melanoma should be photographed. Gross morphological features of primary melanoma associated with metastases

JAMA ◽  
1982 ◽  
Vol 248 (9) ◽  
pp. 1077-1081 ◽  
Author(s):  
C. L. Day
Cancer ◽  
2014 ◽  
Vol 121 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Viswanath Reddy Belum ◽  
Alyx C. Rosen ◽  
Natalia Jaimes ◽  
George Dranitsaris ◽  
Melissa P. Pulitzer ◽  
...  

2018 ◽  
pp. 99-103
Author(s):  
I. F. Shalyga ◽  
G. V. Tishchenko ◽  
L. A. Martemyanova ◽  
S. Yu. Turchenko ◽  
Yu. N. Avizhets

The article describes a case of Letterer-Siwe disease (Langerhans cells histocytosis, histiocytosis X) in a 1-year-old infant, presents the authors` own observations focusing on the macroscopic and histological picture of skin lesions. The work also notes difficulties of diagnosis of this disease. Reliable morphological features of Letterer-Siwe disease were revealed during the histologic examination of the skin.


2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e20052-e20052
Author(s):  
E. George Elias ◽  
Bhuvnesh K Sharma

e20052 Background: Patients with dermal and subdermal metatases as well as invasive primary melanoma allow a great opportunity to evaluate the local and systemic response to intralesional therapy. Methods: Ten patients were studied and completed 2½ years of of follow-up. Four had multiple small intransit metastases each measured 3mm-1cm with 3 to >100 lesions per patient, three had large coalesced sclerotic lesions, and two had distant metastases with palpable subcutaneous nodules. Each received intralesional GM-CSF 500 μg weekly, and in case of failure, IL-2 was substituted at 18 million IU weekly. One patient with invasive primary melanoma and a satellite lesion received both cytokines at the skin lesions one week preoperatively. All the patients had flow cytometric analysis of the peripheral blood before and during therapy. All resected tissues were examined histopathologically and by immunohistochemistry. Results: This was safe and nontoxic program. Three of the four patints with small lesions had complete response (CR) to GM-CSF and one failed but had CR to IL-2. All four patients are alive free of disease for 31-45 months. The three patients with sclerotic lesions failed to respond to either agents. One of the two patients with distant metastases had CR for 6 months. The resected tissues from the patient with primary and satellite lesions revealed complete tumor necrosis with massive histiocytosis and overexpression of CD8+, CD83+ and CD25+ cells at the injection sites and regional lymph nodes and is alive free of disease for over 32 months. The flow cytometric analysis showed no significant changes in white cell differentiation and no dendritic cells were identified before or during therapy. Conclusions: Consequential intralesional administration of GM-CSF and IL-2 seems to have a role in the management of some high-risk patients. While GM-CSF can stimulate autologous dendritic cells, IL-2 activates T cells in the presence of patient own tumor. Such combination can activate a strong antitumor response specific to the patient, which is taken-up by the lymphatics.


Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6071
Author(s):  
Caterina Cariti ◽  
Martina Merli ◽  
Gianluca Avallone ◽  
Marco Rubatto ◽  
Elena Marra ◽  
...  

Background: The current COVID-19 pandemic has influenced the modus operandi of all fields of medicine, significantly impacting patients with oncological diseases and multiple comorbidities. Thus, in recent months, the establishment of melanoma management during the emergency has become a major area of interest. In addition to original articles, case reports and specific guidelines for the period have been developed. Purpose: This article aims to evaluate whether melanoma management has been changed by the outbreak of COVID-19, and if so, what the consequences are. We summarized the main issues concerning the screening of suspicious lesions, the diagnosis of primary melanoma, and the management of early-stage and advanced melanomas during the pandemic. Additionally, we report on the experience of our dermatological clinic in northern Italy. Methods: We performed a literature review evaluating articles on melanomas and COVID-19 published in the last two years on PubMed, as well as considering publications by major healthcare organizations. Concerning oncological practice in our center, we collected data on surgical and therapeutic procedures in patients with a melanoma performed during the first months of the pandemic. Conclusions: During the emergency period, the evaluation of suspicious skin lesions was ensured as much as possible. However, the reduced level of access to medical care led to a documented delay in the diagnosis of new melanomas. When detected, the management of early-stage and advanced melanomas was fully guaranteed, whereas the follow-up visits of disease-free patients have been postponed or replaced with a teleconsultation when possible.


Author(s):  
K. M. Hiwale ◽  
Avadh Kishor Tyagi

Background: Malignant melanoma is mostly found in mucous membranes and skin. So it’s occurrence on the breast skin is very rare. Case Presentation: In our study, 50-year-old female came to OPD with complaint of skin lesions on the breast since 2 months. On diagnosis, skin lesion was found to be malignant melanoma and the disease had metastasized in right axillary lymph node with discoloration over breast. Conclusion: The prognosis for patients with this disease is very poor. Important procedures which may increase the survival rate include, Early diagnosis and surgical resection with adjuvant therapy.


2021 ◽  
Vol 11 (2) ◽  
pp. 118-124
Author(s):  
V. V. Egorenkov ◽  
F. V. Moiseenko ◽  
N. M. Volkov ◽  
M. S. Molchanov ◽  
M. S. Ravkina ◽  
...  

Background. Malignant melanoma is steadily exaggerating over the recent decades. Nonetheless, improved systemic therapies have substantially increased life expectancy in patients with a locally advanced or disseminated disease. Higherincidence recurrent melanocytic skin lesions become essentially problematic and require more attention and control.Aim. Cross-survey on the incidence of synchronous multiple primary melanomas in patients with solitary melanoma and those with other operable solid tumours.Materials and methods. A total of 289 patients with suspected malignant pigmented skin melanoma were included in the survey. Patients were divided in two cohorts by the presence of primary skin melanoma and its tractability for radical excision. Patients with operable melanoma comprised the study cohort, and those with other solid tumours were the control.Results and discussion. The survey covered 289 patients, with 148 in the study and 141 in the control cohort. The study148 patients revealed 112 malignant pigmented melanomas, but none in the control cohort. A chi-square statistical analysis of clinical values in single and multiple melanoma cases showed a slightly higher prevalence of first-visit melanomas in patients with synchronous tumours (30% pT4 — p = 0.007).Conclusion. The observed 10% rate of second melanoma in the study cohort and a zero melanoma incidence in the control support the alternative hypothesis of a higher rate of newly detected melanomas in primarily diagnosed melanoma patients vs. those with solid tumours.


Author(s):  
W.T. Collins ◽  
Charles C. Capen ◽  
Louis Kasza

The widespread contamination of the environment with PCB, a compound used extensively by industry in hydraulic and heat transfer fluids as well as plasticizers and solvents in adhesives and sealants, has resulted in detectable tissue levels in a large portion of the human population, domestic animals, and wildlife. Intoxication with PCB produces severe hepatic necrosis, degeneration of lymphoid tissues and kidney, skin lesions, decreased reproductive performance, reduced feed efficiency, and decreased weight gain. PCB also has been reported to reduce the binding of thyroid hormone to serum proteins and enhance the peripheral metabolism of thyroxine with increased excretion of thyroxine-glucuronide in the bile (Bastomsky, Endocrinology 95: 1150-1155, 1974).The objectives of this investigation were (1) to investigate the histopathologic, histochemical, and ultrastructural changes in thyroid FC produced by the acute (4 week) and chronic (12 week) administration of low (50 ppm) and high (500 ppm) doses of PCB to rats, (2) to correlate these alterations to changes in serum immunoreactive thyroxine concentration, and (3) to investigate the persistence of the effects of PCB on the thyroid gland.


Author(s):  
Necip Güven ◽  
Rodney W. Pease

Morphological features of montmorillonite aggregates in a large number of samples suggest that they may be formed by a dendritic crystal growth mechanism (i.e., tree-like growth by branching of a growth front).


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