Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

2004 ◽  
Author(s):  
Ed Day ◽  
Peter Bentham ◽  
Rhiannon Callaghan ◽  
Turu Kuruvilla ◽  
Sanju George
Keyword(s):  
At Risk ◽  
Alcohol Abuse ◽  
Korsakoff Syndrome

Screening tests for alcoholism or people at risk of alcohol abuse

2000 ◽  
Vol 57 (4) ◽  
pp. 185-190 ◽  
Author(s):  
Allemann
Keyword(s):  
At Risk ◽  
Alcohol Abuse ◽  
Alcohol Dependence ◽  
Screening Tests ◽  
Frühe Diagnose ◽  
Carbohydrate Deficient Transferrin

Es ist allgemein bekannt, daß eine frühe Diagnose im Suchtbereich zu einem besseren therapeutischen Resultat führt und körperliche sowie psychosoziale Folgeschäden, aber auch massive Folgekosten verhindert. Deshalb wurden im Bereich Alkoholscreening in den letzten 15 Jahren weltweit aufwendige Forschungsarbeiten durchgeführt mit allerdings ernüchternden Resultaten. Abgesehen vom noch relativ neuen und teuren CDT-Test (Carbohydrate-deficient Transferrin) und einigen Abänderungen von Fragebögen (vorwiegend Kürzungen) stehen uns momentan als Screeningtests weiterhin nur die seit Jahrzehnten verwendeten und etablierten Methoden zur Verfügung. Das persönliche Gespräch, eine spezifische Anamnese und die Erfahrung des einzelnen Therapeuten wird deshalb auch in Zukunft nicht so rasch ersetzt werden können. Dabei gilt es aber auch in der Zukunft, eigene Ängste vor der Diagnose Alkoholismus und deren allfälligen Folgen sowohl für den Patienten wie auch den Praxisbetrieb zu überwinden. Die Plinius Major Society empfiehlt in ihren «Guidelines on evaluation of treatment of alcohol dependence» als Kurztest (allgemeines Screening) den CAGE-Fragebogen abzugeben, der vom Patienten in kurzer Zeit selbständig durchgeführt werden kann. In der Hausarztpraxis oder der Klinik besser bewährt und aufschlußreicher sind der MALT oder AUDIT, da diese schnell durchführbar und aussagekräftiger sind. Als gängigste und immer noch als die am weitesten verbreiteten Labormarker empfiehlt sie die Durchführung von gamma-GT, MCV, GOT/GPT und CDT

Performance of the Pictorial Representation of Illness and Self Measure in Individuals with Alcohol Dependence, Alcohol Abuse or At-Risk Drinking

2006 ◽  
Vol 75 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Susa Reinhardt ◽  
Gallus Bischof ◽  
Janina Grothues ◽  
Ulrich John ◽  
Hans-Jürgen Rumpf
Keyword(s):  
At Risk ◽  
Alcohol Abuse ◽  
Alcohol Dependence ◽  
Pictorial Representation

scholarly journals Parenteral thiamine use in the prevention and treatment of Wernicke–Korsakoff syndrome

2005 ◽  
Vol 29 (3) ◽  
pp. 94-97 ◽  
Author(s):  
Claire McIntosh ◽  
Valerie Kippen ◽  
Fiona Hutcheson ◽  
Andrew McIntosh
Keyword(s):  
At Risk ◽  
Odds Ratio ◽  
Clinical Implications ◽  
Post Intervention ◽  
Parenteral Treatment ◽  
Korsakoff Syndrome ◽  
Appropriate Treatment ◽  
Prevention And Treatment ◽  
Alcohol Detoxification ◽  
The Mean

Aims and MethodA pre-/post-intervention audit of 163 case notes was conducted to assess the efficacy of printing information about the identification and treatment of the Wernicke–Korsakoff syndrome on the hospital alcohol detoxification sheet.ResultsParenteral thiamine was indicated in 42 of 163 patients; 26 had symptoms suggestive of Wernicke's encephalopathy and 16 were at risk. The intervention increased the chance of appropriate parenteral treatment by an odds ratio of 5.9 (95% CI 1.3–27.8). Admission to a specialist alcohol unit increased the chance of appropriate treatment by an odds ratio of 7.0 (95% CI 1.52–32.25). The mean number of doses rose from 3.08 to 4.62.Clinical ImplicationsA simple intervention may lead to improved treatment of patients with Wernicke–Korsakoff syndrome.

scholarly journals Impact of Alcohol Abuse on Susceptibility to Rare Neurodegenerative Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Iskra Araujo ◽  
Amy Henriksen ◽  
Joshua Gamsby ◽  
Danielle Gulick
Keyword(s):  
Alcohol Abuse ◽  
Neurodegenerative Diseases ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Small Population ◽  
Ample Evidence ◽  
Korsakoff Syndrome ◽  
Niemann Pick Disease ◽  
Population Sizes ◽  
Niemann Pick

Despite the prevalence and well-recognized adverse effects of prenatal alcohol exposure and alcohol use disorder in the causation of numerous diseases, their potential roles in the etiology of neurodegenerative diseases remain poorly characterized. This is especially true of the rare neurodegenerative diseases, for which small population sizes make it difficult to conduct broad studies of specific etiological factors. Nonetheless, alcohol has potent and long-lasting effects on neurodegenerative substrates, at both the cellular and systems levels. This review highlights the general effects of alcohol in the brain that contribute to neurodegeneration across diseases, and then focuses on specific diseases in which alcohol exposure is likely to play a major role. These specific diseases include dementias (alcohol-induced, frontotemporal, and Korsakoff syndrome), ataxias (cerebellar and frontal), and Niemann-Pick disease (primarily a Type B variant and Type C). We conclude that there is ample evidence to support a role of alcohol abuse in the etiology of these diseases, but more work is needed to identify the primary mechanisms of alcohol’s effects.

Thiamine for Wernicke-Korsakoff Syndrome in people at risk from over-consumption of alcohol

2002 ◽  
Author(s):  
E Day ◽  
P Bentham ◽  
R Callaghan ◽  
T Kuruvilla ◽  
S George
Keyword(s):  
At Risk ◽  
Korsakoff Syndrome

scholarly journals COVID-19-Related Neuropsychiatric Symptoms in Patients With Alcohol Abuse Conditions During the SARS-CoV-2 Pandemic: A Retrospective Cohort Study Using Real World Data From Electronic Health Records of a Tertiary Hospital

2021 ◽  
Vol 12 ◽  
Author(s):  
Carolina Varela Rodríguez ◽  
Francisco Arias Horcajadas ◽  
Cristina Martín-Arriscado Arroba ◽  
Carolina Combarro Ripoll ◽  
Alba Juanes Gonzalez ◽  
...  
Keyword(s):  
At Risk ◽  
Cohort Study ◽  
Alcohol Abuse ◽  
Retrospective Cohort ◽  
Neuropsychiatric Symptoms ◽  
Personal History ◽  
Real World Data ◽  
Health Records ◽  
History Of ◽  
Electronic Health

Patients with an alcohol abuse disorder exhibit several medical characteristics and social determinants, which suggest a greater vulnerability to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and a worse course of the coronavirus disease 2019 (COVID-19) once infected. During the first wave of the COVID-19, most of the countries have register an increase in alcohol consumption. However, studies on the impact of alcohol addiction on the risk of COVID-19 infection are very scarce and inconclusive. This research offers a descriptive observational retrospective cohort study using real world data obtained from the Electronic Health Records. We found that patients with a personal history of alcohol abuse were 8% more likely to extend their hospitalization length of stay for 1 day (95% CI = 1.04–1.12) and 15% more likely to extend their Intensive Care Unit (ICU) length of stay (95% CI = 1.01–1.30). They were also 5.47 times more at risk of needing an ICU admission (95% CI = 1.61–18.57) and 3.54 times (95% CI = 1.51–8.30) more at risk of needing a respirator. Regarding COVID-19 symptoms, patients with a personal history of alcohol abuse were 91% more likely of exhibiting dyspnea (95% CI = 1.03–3.55) and 3.15 times more at risk of showing at least one neuropsychiatric symptom (95% CI = 1.61–6.17). In addition, they showed statistically significant differences in the number of neuropsychiatric symptoms developed during the COVID-19 infection. Therefore, we strongly recommend to warn of the negative consequences of alcohol abuse over COVID-19 complications. For this purpose. Clinicians should systematically assess history of alcohol issues and drinking habits in all patients, especially for those who seek medical advice regarding COVID-19 infection, in order to predict its severity of symptoms and potential complications. Moreover, this information should be included, in a structured field, into the Electronic Health Record to facilitate the automatic extraction of data, in real time, useful to evaluate the decision-making process in a dynamic context.

scholarly journals The influence of alcohol abuse on agitation, delirium and sedative requirements of patients admitted to a general intensive care unit

2018 ◽  
Vol 20 (3) ◽  
pp. 208-215
Author(s):  
Donald Stewart ◽  
John Kinsella ◽  
Joanne McPeake ◽  
Tara Quasim ◽  
Alex Puxty
Keyword(s):  
Intensive Care Unit ◽  
At Risk ◽  
Intensive Care ◽  
Alcohol Abuse ◽  
Low Risk ◽  
World Health ◽  
Related Disease ◽  
Risk Patients ◽  
The Impact ◽  
Alcohol Dependent

Purpose Patients with alcohol-related disease constitute an increasing proportion of those admitted to intensive care unit. There is currently limited evidence regarding the impact of alcohol use on levels of agitation, delirium and sedative requirements in intensive care unit. This study aimed to determine whether intensive care unit-admitted alcohol-abuse patients have different sedative requirements, agitation and delirium levels compared to patients with no alcohol issues. Methods This retrospective analysis of a prospectively acquired database (June 2012–May 2013) included 257 patients. Subjects were stratified into three risk categories: alcohol dependency (n = 69), at risk (n = 60) and low risk (n = 128) according to Fast Alcohol Screening Test scores and World Health Organisation criteria for alcohol-related disease. Data on agitation and delirium were collected using validated retrospective chart-screening methods and sedation data were extracted and then log-transformed to fit the regression model. Results Incidence of agitation (p = 0.034) and delirium (p = 0.041) was significantly higher amongst alcohol-dependent patients compared to low-risk patients as was likelihood of adverse events (p = 0.007). In contrast, at-risk patients were at no higher risk of these outcomes compared to the low-risk group. Alcohol-dependent patients experienced suboptimal sedation levels more frequently and received a wider range of sedatives (p = 0.019) but did not receive higher daily doses of any sedatives. Conclusions Our analysis demonstrates that when admitted to intensive care unit, it is those who abuse alcohol most severely, alcohol-dependent patients, rather than at-risk drinkers who have a significantly increased risk of agitation, delirium and suboptimal sedation. These patients may require closer assessment and monitoring for these outcomes whilst admitted.

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