Comprehensive analysis of BTN3A1 in cancers: mining of omics data and validation in patient samples and cellular models

AbstractUnderstanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Here, we present Phase 1 of a multi-omics, multi-model data resource for FTD research which will allows in-depth molecular research into these mechanisms. We have integrated and analysed data from the frontal lobe of FTD patients with mutations in MAPT, GRN and C9orf72 and detected common and distinct dysregulated cellular pathways. Our results highlight that excitatory neurons are the most vulnerable neuronal cell type and that vascular aberrations are a common hallmark in FTD. Via integration of multi-omics data, we detected several transcription factors and pathways which regulate the strong neuroinflammation observed in FTD-GRN. Finally, using small RNA-seq data and verification experiments in cellular models, we identified several up-regulated miRNAs that inhibit cellular trafficking pathways in FTD and lead to microglial activation. In this work we shed light on novel mechanistic and pathophysiological hallmarks of FTD. In addition, we believe that this comprehensive, multi-omics data resource will further mechanistic FTD research by the community.

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Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy

Nature Communications ◽

10.1038/s41467-019-12282-7 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 3

Author(s):

Madoka Iida ◽

Kentaro Sahashi ◽

Naohide Kondo ◽

Hideaki Nakatsuji ◽

Genki Tohnai ◽

...

Keyword(s):

Skeletal Muscles ◽

Kinase Inhibitor ◽

Muscular Atrophy ◽

Intraperitoneal Administration ◽

Src Kinase ◽

Comprehensive Analysis ◽

Cag Repeat ◽

Cellular Models ◽

Phosphorylated Proteins ◽

Three Stages

Abstract Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by an expanded CAG repeat in the androgen receptor (AR) gene. Here, we perform a comprehensive analysis of signaling pathways in a mouse model of SBMA (AR-97Q mice) utilizing a phosphoprotein assay. We measure the levels of 17 phosphorylated proteins in spinal cord and skeletal muscle of AR-97Q mice at three stages. The level of phosphorylated Src (p-Src) is markedly increased in the spinal cords and skeletal muscles of AR-97Q mice prior to the onset. Intraperitoneal administration of a Src kinase inhibitor improves the behavioral and histopathological phenotypes of the transgenic mice. We identify p130Cas as an effector molecule of Src and show that the phosphorylated p130Cas is elevated in murine and cellular models of SBMA. These results suggest that Src kinase inhibition is a potential therapy for SBMA.

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New Source Book Offers Comprehensive Analysis of Kinship Care Policies and Practices

PsycEXTRA Dataset ◽

10.1037/e724542011-001 ◽

2003 ◽

Keyword(s):

Kinship Care ◽

Comprehensive Analysis ◽

Source Book ◽

Care Policies ◽

Policies And Practices

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Review for "The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community"

10.1002/jbmr.4147/v1/review3 ◽

2020 ◽

Keyword(s):

Scientific Community ◽

Omics Data ◽

Knowledge Portal

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Sozial-räumliche Dynamiken der Agrartreibstoffe.

PROKLA Zeitschrift für kritische Sozialwissenschaft ◽

10.32387/prokla.v46i184.123 ◽

2016 ◽

Vol 46 (184) ◽

pp. 423-440 ◽

Cited By ~ 1

Author(s):

Kristina Dietz ◽

Bettina Engels ◽

Oliver Pye

Keyword(s):

Political Economy ◽

Capital Flows ◽

Spatial Dynamics ◽

Financial Sector ◽

Comprehensive Analysis ◽

Spatial Theory ◽

Global Political Economy

This article explores the spatial dynamics of agrofuels. Building on categories from the field of critical spatial theory, it shows how these categories enable a comprehensive analysis of the spatial dynamics of agrofuels that links the macro-structures of the global political economy to concrete, place-based struggles. Four core socio-spatial dynamics of agrofuel politics are highlighted and applied to empirical findings: territorialization, the financial sector as a new scale of regulation, place-based struggles and transnational spaces of resources and capital flows.

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Concerning the abuse of power by an official

Scientific and Informational Bulletin of Ivano-Frankivsk University of Law Named after King Danylo Halytskyi - Scientific and informational bulletin of Ivano-Frankivsk University of Law named after King Danylo Halytskyi ◽

10.33098/2078-6670.2020.9.21.103-110 ◽

2020 ◽

pp. 103-110

Author(s):

Ihor Oheruk

Keyword(s):

Criminal Code ◽

Comprehensive Analysis ◽

Practical Significance ◽

Abuse Of Power ◽

Government Functions ◽

Analysis And Synthesis ◽

The Status ◽

The Subject ◽

Criminal Legislation ◽

Logical Semantic

Purpose. The purpose of the work is to analyze the application of the second and third parts of Article 3692 of the Criminal Code of Ukraine to officials in the context, that defines them by the Criminal Code of Ukraine in the note to Article 364 of the Criminal Code of Ukraine. Methodology. The methodology includes a comprehensive analysis and synthesis of the available scientific and theoretical material and the formulation of relevant conclusions and recommendations. In the course of the study, the following methods of scientific knowledge were used: terminological, logical-semantic, system-structural, logical-normative. Results: in the course of research the cause of criminalization of such act as "abuse of power" is considered, the subject of the specified criminal act which has the features of "an official" in the context, that defines it by the note to Article 364 of the Criminal Code of Ukraine is analyzed and the main ways of committing criminal acts, that are provided for in this article of the Criminal Code of Ukraine are identified. Originality. The study found, that one of the key conditions for the opportunity to influence officials, that are authorized to perform government or local self-government functions, is the position held by the official and the related opportunities. Therefore, taking into account the opinion of the scientists, that the subject of crimes, that are provided for by the second and third parts of Article 3692 is special, the peculiarities of which is the cumulative feature, that denotes, that such person is not endowed with the status of an official, well-founded need to specify the criminal legislation of Ukraine in terms of the application the second and third parts of Article 3692 of the Criminal code of Ukraine concerning officials in the context, that defines them by the criminal legislation of Ukraine in the note to Article 364 of the Criminal Code of Ukraine. Practical significance. The research results can be used in lawmaking in the improvement of anti-corruption legislation.

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BASIC FUNDAMENTALS OF CIVIL LAW AND THEIR IMPORTANCE

Scientific and Informational Bulletin of Ivano-Frankivsk University of Law Named after King Danylo Halytskyi - Scientific and informational bulletin of Ivano-Frankivsk University of Law named after King Danylo Halytskyi ◽

10.33098/2078-6670.2019.8.20.120-126 ◽

2019 ◽

pp. 120-126

Author(s):

Diana Vivcharuk

Keyword(s):

Law Enforcement ◽

Scientific Knowledge ◽

Civil Law ◽

Comprehensive Analysis ◽

Practical Significance

Purpose. The purpose of the article is the regulation of relations on the principles of civil law. Methodology. The methodology includes a comprehensive analysis and a synthesis of available scientific and theoretical information. It is includes the formulation of relevant conclusions and recommendations. Such methods of scientific knowledge were used: terminological, functional, systemic-structural, logical-normative. Results: it was determined, that principles of civil law – an ideas of the civil law, that characterized by systematic,versatile, more stable, more regylated. Originality. An article is the special reseach that explores the problems of civil law in Ukraine. Practical significance. The results of the research can be used in legislation and law-enforcement activities.

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AKAD FINANCING OF MURABAHAH BETWEEN CUSTOMERS WITH MUAMALAT BANKS HARKAT VIEWED FROM SHARI'AH PRINCIPLES

Bengkoelen Justice : Jurnal Ilmu Hukum ◽

10.33369/j_bengkoelenjust.v10i1.11340 ◽

2020 ◽

Vol 10 (1) ◽

pp. 13-26

Author(s):

Candra Irawan ◽

Adi Bastian ◽

Febrozi Rohadi

Keyword(s):

Data Collection ◽

Financial Institutions ◽

Research Method ◽

Economic Condition ◽

Field Research ◽

Comprehensive Analysis ◽

Islamic Banks ◽

Legal Research ◽

Trading System ◽

Library Research

Currently in Indonesia Islamic Bank has gained a place and interested in the community, causing many emerging Syari'ah Bank and Financial Institutions of the syari'ah, and products in Islamic banks are widely used is murabahah financing. The formulation of the problem in this research are: (1). How is the implementation of the sale and purchase through murabahah financing between Bank Muamalat Harkat with customers. (2). Is trading system murabahah financing between Bank Muamalat Harkat and customers have been according to the principles of Syari’ah. (3). How murabahah financing efforts to resolve the breach between the customer and Muamalat Harkat. This research method is empirical legal research, this study was conducted in Bank Muamalat Harkat based data collection through field research such as interviews, observation and description as well as information from respondents through library research. The results of this research are: before an agreement Bank to assess carefully the prospective customer in the form of a comprehensive analysis and is divided into several stages, such as the assessment using the principle of 5C Character (Character of the debitor), Chapacity (Capability Candidate Debitor) , Capital (Capital candidate Debitor), Collateral (Collateral candidate Debitor) and Condition of economy (economic condition of the prospective Borrower). Trading system murabahah financing between Bank Muamalat Harkat with the customer has not fully based on the principles of the Syari'ah. Murabahah financing efforts to resolve the defaults can be solved by R3 is Restrukturing (Arrangement Back), Reconditioning (Terms Back) and Rescheduling (rescheduling), sales collateral and auction execution.

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