Synthesis of Amphiphilic Copolymers of Poly(ethylene oxide) and Poly(ε-caprolactone) with Different Architectures, and Their Role in the Preparation of Stealthy Nanoparticles

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.

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Increase in the length of poly(ethylene oxide) blocks in amphiphilic copolymers facilitates their cellular uptake

Journal of Applied Polymer Science ◽

10.1002/app.45492 ◽

2017 ◽

Vol 134 (44) ◽

pp. 45492 ◽

Cited By ~ 6

Author(s):

Irene D. Grozdova ◽

Gennadiy A. Badun ◽

Maria G. Chernysheva ◽

Victor N. Orlov ◽

Andrey V. Romanyuk ◽

...

Keyword(s):

Ethylene Oxide ◽

Cellular Uptake ◽

Amphiphilic Copolymers ◽

Poly Ethylene Oxide ◽

Poly Ethylene

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Diblock, Triblock and Cyclic Amphiphilic Copolymers with CO2 Switchability: Effects of Topology

Polymers ◽

10.3390/polym12040984 ◽

2020 ◽

Vol 12 (4) ◽

pp. 984

Author(s):

Yuting Jiang ◽

Tong Zhang ◽

Zheng Yi ◽

Yixiu Han ◽

Xin Su ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Oxide ◽

Atom Transfer Radical Polymerization ◽

Radical Polymerization ◽

Hydrodynamic Size ◽

Amphiphilic Copolymers ◽

Ethyl Methacrylate ◽

Cyclic Molecules ◽

Poly Ethylene Oxide ◽

Poly Ethylene

The combination of topology and CO2 switchability could provide new options for amphiphilic copolymers. Cyclic molecules supply novel topologies, and CO2 switching provides stimulus responsiveness. Cyclic poly(2–(diethylamino)ethyl methacrylate)–b–poly(ethylene oxide) and their corresponding block copolymers were prepared from poly(ethylene oxide) and 2–(diethylamino)ethyl methacrylate via atom transfer radical polymerization and Keck allylation with a Hoveyda–Grubbs catalyst. Changes in conductivity, surface activity, and hydrodynamic size were examined to illustrate the switchability of the produced amphiphilic copolymers upon contact with CO2 in the presence of water. The reversible emulsification and switchable viscosity behaviors of the copolymers were also demonstrated.

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A comparison of covalent and noncovalent strategies for paclitaxel release using poly(ester amide) graft copolymer micelles

Canadian Journal of Chemistry ◽

10.1139/cjc-2014-0349 ◽

2015 ◽

Vol 93 (4) ◽

pp. 399-405 ◽

Cited By ~ 6

Author(s):

Abdolrasoul Soleimani ◽

Mahmoud M. Abd Rabo Moustafa ◽

Aneta Borecki ◽

Elizabeth R. Gillies

Keyword(s):

Ethylene Oxide ◽

Graft Copolymer ◽

Drug Carriers ◽

Prolonged Release ◽

Amphiphilic Copolymers ◽

Release Rates ◽

Drug Molecules ◽

Poly Ethylene Oxide ◽

Poly Ethylene

Micelles formed from amphiphilic copolymers are promising for the delivery of drug molecules, potentially leading to enhanced properties and efficacies. Critical aspects of these systems include the use of biocompatible, biodegradable polymer backbones as well as the ability to control the incorporation of drugs and their release rates. In this work, a poly(ester amide)–poly(ethylene oxide) graft copolymer with paclitaxel conjugated via ester linkages was prepared and assembled into micelles. For comparison, micelles with physically encapsulated paclitaxel were also prepared. The release rates of these two systems were studied, and the micelles with covalently conjugated paclitaxel exhibited a prolonged release of the drug in comparison to the noncovalent system, which rapidly released the payload. In vitro studies suggested that the poly(ester amide)–poly(ethylene oxide) copolymers were nontoxic, whereas the toxicities of the drug-loaded micelles were dependent on their release rates. Overall, these systems are promising for further development as anticancer drug carriers.

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Synthesis of amphiphilic copolymers with a dendritic polyethylene core and poly(ethylene oxide) arms and their self-assembled nanostructures

Polymer Chemistry ◽

10.1039/c2py20831h ◽

2013 ◽

Vol 4 (4) ◽

pp. 1107-1114 ◽

Cited By ~ 22

Author(s):

Haiyang Gao ◽

Ying Tang ◽

Zhilong Hu ◽

Qirui Guan ◽

Xinbo Shi ◽

...

Keyword(s):

Ethylene Oxide ◽

Amphiphilic Copolymers ◽

Poly Ethylene Oxide ◽

Self Assembled ◽

Poly Ethylene

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The Structure of Radiation Cross-Linked Poly (ethylene oxide) Gels

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100064438 ◽

1971 ◽

Vol 29 ◽

pp. 76-77

Author(s):

C. E. Cluthe ◽

G. G. Cocks

Keyword(s):

Molecular Weight ◽

Ethylene Oxide ◽

Parallel Plate ◽

Average Molecular Weight ◽

Radical Reaction ◽

Free Radical Reaction ◽

Nitrogen Gas ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Initial Viscosity

Aqueous solutions of a 1 weight-per cent poly (ethylene oxide) (PEO) were degassed under vacuum, transferred to a parallel plate viscometer under a nitrogen gas blanket, and exposed to Co60 gamma radiation. The Co60 source was rated at 4000 curies, and the dose ratewas 3.8x105 rads/hr. The poly (ethylene oxide) employed in the irradiations had an initial viscosity average molecular weight of 2.1 x 106.The solutions were gelled by a free radical reaction with dosages ranging from 5x104 rads to 4.8x106 rads.

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