scholarly journals Simvastatin maintains white matter integrity in healthy middle‐aged adults with increased risk for Alzheimer’s disease: A secondary analysis of a randomized controlled trial

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Nicholas M Vogt ◽  
Jack FV Hunt ◽  
Yue Ma ◽  
Carol A Van Hulle ◽  
Nagesh Adluru ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Randomized Controlled Trial ◽  
White Matter ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
White Matter Integrity ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Increased Risk ◽  
Middle Aged Adults

scholarly journals Improved balance in middle-aged adults after 8 weeks of a modified version of Otago Exercise Program: A randomized controlled trial

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0235734
Author(s):  
Rana Almarzouki ◽  
Gurinder Bains ◽  
Everett Lohman ◽  
Bruce Bradley ◽  
Todd Nelson ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Exercise Program ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Middle Aged Adults

scholarly journals Exercise Training as a Treatment for Cardiometabolic Risk in Sedentary Adults: Are Physical Activity Guidelines the Best Way to Improve Cardiometabolic Health? The FIT-AGEING Randomized Controlled Trial

2019 ◽  
Vol 8 (12) ◽  
pp. 2097 ◽  
Author(s):  
Francisco J. Amaro-Gahete ◽  
Alejandro De-la-O ◽  
Lucas Jurado-Fasoli ◽  
Borja Martinez-Tellez ◽  
Jonatan R. Ruiz ◽  
...  
Keyword(s):  
Physical Activity ◽  
Randomized Controlled Trial ◽  
Exercise Training ◽  
Cardiometabolic Risk ◽  
Controlled Trial ◽  
Whole Body ◽  
Control Group ◽  
Middle Aged ◽  
Randomized Controlled ◽  
Middle Aged Adults

This 12-week randomized controlled trial investigates the effects of different training modalities on cardiometabolic risk in sedentary, middle-aged adults, and examines whether alterations in cardiometabolic risk are associated with changes in those health-related variables that are modifiable by exercise training. The study subjects were 71 middle-aged adults (~54 years old; ~50% women) who were randomly assigned to one of the following treatment groups: (1) no exercise (control group), (2) concurrent training based on international physical activity recommendations (PAR group), (3) high intensity interval training (HIIT) group, or (4) HIIT plus whole-body electromyostimulation (HIIT+EMS group). A cardiometabolic risk score was calculated based on the International Diabetes Federation’s clinical criteria. A significant reduction in cardiometabolic risk was observed for all exercise training groups compared to the control group (all p < 0.05), which persisted after adjusting potential confounders (all p < 0.05). However, the HIIT+EMS group experienced the most significant reduction (p < 0.001). A significant inverse relationship was detected between the change in lean mass and the change in cardiometabolic risk (p = 0.045). A 12-week exercise training programs-especially the HIIT+EMS program-significantly reduced cardiometabolic risk in sedentary, middle-aged adults independent of sex, age, and cardiorespiratory fitness.

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