The relationship between interictal and ictal paroxysms in an in vitro model of focal hippocampal epilepsy

Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected.

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A Human 3D In Vitro Model to Assess the Relationship Between Osteoporosis and Dissemination to Bone of Breast Cancer Tumor Cells

Journal of Cellular Physiology ◽

10.1002/jcp.25708 ◽

2017 ◽

Vol 232 (7) ◽

pp. 1826-1834 ◽

Cited By ~ 9

Author(s):

Francesca Salamanna ◽

Veronica Borsari ◽

Silvia Brogini ◽

Paola Torricelli ◽

Simona Cepollaro ◽

...

Keyword(s):

Breast Cancer ◽

Tumor Cells ◽

In Vitro Model ◽

3D In Vitro Model ◽

Cancer Tumor ◽

Vitro Model ◽

The Relationship

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The influence of downstream arterial perfusion parameters on Doppler pulsatility index and resistance index in an in-vitro perfusion model

VASA ◽

10.1024/0301-1526.35.1.5 ◽

2006 ◽

Vol 35 (1) ◽

pp. 5-10 ◽

Cited By ~ 2

Author(s):

Schmidt ◽

Ockert ◽

Deußen ◽

Schellong

Keyword(s):

Reflection Coefficient ◽

Pulsatility Index ◽

In Vitro Model ◽

Peripheral Resistance ◽

Resistance Index ◽

In Vitro Perfusion ◽

Arterial Perfusion ◽

Vitro Model ◽

The Relationship

Background: To investigate in vitro how downstream perfusion parameters influence pulsatility index (PI), resistance index (RI) and their constituting Doppler velocities. Materials and methods: We analyzed the influence of resistance, compliance, reflection coefficient and input impedance on PI and RI in an in-vitro model of arterial flow. Results: The nominators of PI and RI were determined by resistance. The numerators were determined by compliance and by the reflection coefficient. There were close relationships of PI and RI with resistance under the condition of constant compliance, but not when compliance was variable. Conclusion: PI and RI consist of velocity terms which are independently influenced by different parameters of impedance: compliance, reflection coefficient and resistance. These findings explain the contradictory results reported for the relationship between the indices and peripheral resistance in studies where compliance and reflection effects were not considered.

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The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression

Oncogene ◽

10.1038/sj.onc.1206709 ◽

2003 ◽

Vol 22 (39) ◽

pp. 7969-7980 ◽

Cited By ~ 38

Author(s):

Trond Aasen ◽

Malcolm B Hodgins ◽

Michael Edward ◽

Sheila V Graham

Keyword(s):

Cervical Cancer ◽

Gap Junctions ◽

Cancer Progression ◽

In Vitro Model ◽

Tumour Invasion ◽

Tissue Architecture ◽

Hpv 16 ◽

Vitro Model ◽

The Relationship

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A New in vitro Model to Study the Relationship of Gap Size and Secondary Caries

Caries Research ◽

10.1159/000107934 ◽

2007 ◽

Vol 41 (6) ◽

pp. 467-473 ◽

Cited By ~ 77

Author(s):

P. Totiam ◽

C. González-Cabezas ◽

M.R. Fontana ◽

D.T. Zero

Keyword(s):

In Vitro Model ◽

Gap Size ◽

Secondary Caries ◽

Vitro Model ◽

Relationship Of ◽

The Relationship

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An in vitro model for investigation of vitamin A effects on wound healing

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000692 ◽

2021 ◽

pp. 1-6

Author(s):

Hoda Keshmiri Neghab ◽

Mohammad Hasan Soheilifar ◽

Gholamreza Esmaeeli Djavid

Keyword(s):

Wound Healing ◽

Endothelial Cell ◽

Vitamin A ◽

In Vitro Model ◽

Cellular Proliferation ◽

Endothelial Cell Migration ◽

Normal Fibroblast ◽

Anti Inflammatory ◽

Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inﬂammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inﬂammation responses.

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