Effect of degree of substitution and molecular weight of carboxymethyl chitosan nanoparticles on doxorubicin delivery

2006 ◽  
Vol 100 (6) ◽  
pp. 4689-4696 ◽  
Author(s):  
Xiaowen Shi ◽  
Yumin Du ◽  
Jianhong Yang ◽  
Baozhong Zhang ◽  
Liping Sun
Keyword(s):  
Molecular Weight ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
Degree Of Substitution ◽  
Doxorubicin Delivery

scholarly journals Chitosan and Carboxymethyl Chitosan from Fish Scales of Labeo rohita

2013 ◽  
Vol 61 (1) ◽  
pp. 145-148 ◽  
Author(s):  
Tanvir Muslim ◽  
Mohammad Habibur Rahman ◽  
HOsne Ara Begum ◽  
Md. Azizur Rahman
Keyword(s):  
Molecular Weight ◽  
Spectral Analysis ◽  
Labeo Rohita ◽  
Carboxymethyl Chitosan ◽  
Degree Of Substitution ◽  
Monochloroacetic Acid ◽  
Fish Scales ◽  
Ft Ir

Chitin was extracted from the fish scales of Labeo rohita and chitosan was successfully prepared from it by deacetylation reaction. The prepared chtiosan was characterized by FT-IR spectral analysis and degree of decetylation was determined by pH-metric titration. The molecular weight of chitosan was estimated by viscometric method. Chitosan was converted into its carboxymethyl derivative using alkali and monochloroacetic acid. The prepared carboxymethyl chitosan was characterized by FT-IR spectral analysis and degree of substitution was estimated. Dhaka Univ. J. Sci. 61(1): 145-148, 2013 (January) DOI: http://dx.doi.org/10.3329/dujs.v61i1.15116

Preparation and optimization of N-trimethyl-O-carboxymethyl chitosan nanoparticles for delivery of low-molecular-weight heparin

2014 ◽  
Vol 21 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Reza Mahjub ◽  
Tavakol Heidari Shayesteh ◽  
Moojan Radmehr ◽  
Seyed Yaser Vafaei ◽  
Mohsen Amini ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
Low Molecular Weight

HES 200/0.5 Is not HES 200/0.5

1995 ◽  
Vol 74 (06) ◽  
pp. 1452-1456 ◽  
Author(s):  
Johannes Treib ◽  
Anton Haass ◽  
Gerhard Pindur ◽  
Ulrich T Seyfert ◽  
Wolfgang Treib ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Hydroxyethyl Starch ◽  
Clinical Relevance ◽  
Dilution Effect ◽  
Repeated Administration ◽  
Plasma Viscosity ◽  
Degree Of Substitution ◽  
Pronounced Increase ◽  
Large Molecules ◽  
Mean Molecular Weight

SummaryThe plasma clearance of hydroxyethyl starch (HES) depends on the initial molecular weight and the degree of substitution. So far, little attention has been paid to the clinical relevance of the C2/C6 substitution ratio of hydroxyethyl starch.10 patients with cerebrovascular circulatory disturbance received hemodilution therapy for 10 days, consisting of 10% HES 200/0.5 (mean molecular weight 200 kD, degree of substitution 0.5) with a C2/C6 ratio of 13.4. A second group of 10 patients received a starch solution with identical initial molecular weight and degree of substitution but with a C2/C6 ratio of 5.7.After the administration of a single dose, no significant differences between the two groups were observed. After repeated administration, significant differences could be detected in hemorheology, coagulation and elimination (p<0.01). The larger C2/C6 ratio led to a higher intravascular mean molecular weight (95 vs. 84 kD), which in turn led to a higher increase in serum concentration during the therapy (14.7 vs.8.6 mg/ml). Hematocrit was lowered more (-30,5 vs. -23,5%) and plasma viscosity was increased more. There was also a more pronounced increase in partial thromboplastin time (+30% vs. +13%) and a factor of 2 larger decrease of factor VIII/von Willebrand factor-complex (p <0.01), which exceeded the dilution effect.The higher C2/C6 ratio of HES 200/0.5/13.4 slows down enzymatic degradation. After repeated administration of this starch, large molecules accumulate which are inefficiently degraded. The same effect has been observed after therapy with highly-substituted HES. This accumulation of large molecules leads to a beneficial longer lasting volume effect. The disadvantages include an increase in plasma viscosity and coagulation disturbances, which cannot be explained with the respective dilution effect alone. For these reasons, the C2/C6 ratio is of clinical relevance and should be included in the product labeling in the future.

Smart flame retardant coating containing carboxymethyl chitosan nanoparticles decorated graphene for obtaining multifunctional textiles

Cellulose ◽  
2021 ◽  
Author(s):  
Emad S. Goda ◽  
Mahmoud H. Abu Elella ◽  
Sang Eun Hong ◽  
Bidhan Pandit ◽  
Kuk Ro Yoon ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan

The effect of doxycycline-containing chitosan/carboxymethyl chitosan nanoparticles on NLRP3 inflammasome in periodontal disease

2020 ◽  
Vol 237 ◽  
pp. 116163
Author(s):  
Shuo Xu ◽  
Qihui Zhou ◽  
Zhongxin Jiang ◽  
Yanwen Wang ◽  
Kai Yang ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Nlrp3 Inflammasome ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan

1H-NMR Analysis of Degree of Substitution in N,O-Carboxymethyl Chitosans from Various Chitosan Sources and Types

2012 ◽  
Vol 506 ◽  
pp. 158-161 ◽  
Author(s):  
A. Jaidee ◽  
Pornchai Rachtanapun ◽  
S. Luangkamin
Keyword(s):  
Chemical Structure ◽  
Carboxymethyl Chitosan ◽  
Degree Of Substitution ◽  
Resonance Spectroscopy ◽  
Nmr Analysis ◽  
Reaction Conditions ◽  
H Nmr ◽  
Fourier Transformed Infrared Spectroscopy ◽  
Chitosan Oligomer ◽  
Ft Ir

N,O-Carboxymethyl chitosans were synthesized by the reaction between shrimp, crab and squid chitosans with monochloroacetic acid under basic conditions at 50°C. The mole ratio of reactants was obtained from various reaction conditions of shrimp chitosan polymer and oligomer types. The mole ratio 1:12:6 of chitosan:sodium hydroxide:monochloroacetic acid was used for preparing carboxymethyl of chitosan polymer types while carboxymethyl of chitosan oligomer types were used the mole ratio 1:6:3 of chitosan:sodium hydroxide:monochloroacetic acid. The chemical structure was analyzed by fourier transformed infrared spectroscopy (FT-IR) and proton nuclear magnatic resonance spectroscopy (1H-NMR). The FT-IR was used for confirm the insertion of carboxymethyl group on chitosan molecules. The 1H-NMR was used for determining the degree of substitution (DS) of carboxymethylation at hydroxyl and amino sites of chitosans. Carboxymethyl chitosan samples had the total DS of carboxymethylation ranging from 1.0-2.2. The highest of DS of carboxymethylation was from shrimp chitosan oligomer type.

O-Carboxymethyl chitosan nanoparticles for metformin delivery to pancreatic cancer cells

2012 ◽  
Vol 89 (3) ◽  
pp. 1003-1007 ◽  
Author(s):  
K.S. Snima ◽  
R. Jayakumar ◽  
A.G. Unnikrishnan ◽  
Shantikumar. V. Nair ◽  
Vinoth-Kumar Lakshmanan
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
Pancreatic Cancer Cells

scholarly journals Synthesis, Characterization, and Evaluation of Genistein-Loaded Zein/Carboxymethyl Chitosan Nanoparticles with Improved Water Dispersibility, Enhanced Antioxidant Activity, and Controlled Release Property

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1604
Author(s):  
Yu Xiao ◽  
Chi-Tang Ho ◽  
Yulian Chen ◽  
Yuanliang Wang ◽  
Zihao Wei ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Controlled Release ◽  
Water Solubility ◽  
Uv Light ◽  
Chitosan Nanoparticles ◽  
Carboxymethyl Chitosan ◽  
Food Ingredient ◽  
Beneficial Effects ◽  
Release Property ◽  
Water Dispersibility

Genistein is one of major isoflavones derived from soybean products and it is believed to have beneficial effects on human health. However, its low water-solubility and poor oral bioavailability severely hamper its use as a functional food ingredient or for pharmaceutical industry. In this study, zein and zein/carboxymethyl chitosan (CMCS) nanoparticles were prepared to encapsulate genistein using a combined liquid–liquid phase separation method. The physicochemical properties of fabricated nanoparticles were characterized by dynamic light scattering (DLS), atomic force microscopy (AFM), and Fourier transform infrared spectroscopy (FTIR). The results demonstrated that genistein encapsulated with zein nanoparticles significantly improved its water dispersibility, antioxidant activity in the aqueous phase, and photostability against UV light. Moreover, genistein encapsulated in zein nanoparticles showed a sustained release property. Furthermore, it was found that encapsulation efficiency of genistein was significantly enhanced after CMCS coating, and this effect was more pronounced after the complex nanoparticles cross-linked with calcium ions when compared with the use of zein as a single encapsulant. In addition, compared to zein nanoparticles without biopolymer coating, CMCS coating significantly enhanced the thermal and storage stability of the formed nanoparticles, and delayed the release of genistein. A schematic diagram of zein and zein/carboxymethyl chitosan (CMCS) nanoparticles formation mechanism for encapsulation of genistein was proposed. According to the results of the current study, it could be concluded that encapsulation of genistein in zein/CMCS nanoparticles is a promising approach to improve its water dispersibility, antioxidant activity, photostability against UV light and provide controlled release for food/pharmaceutical applications.

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