Synthesis andin vitroassessment of novel water-soluble dextran-docetaxel conjugates as potential pH sensitive system for tumor-targeted delivery

2017 ◽  
Vol 134 (43) ◽  
pp. 45457 ◽  
Author(s):  
Elahehnaz Parhizkar ◽  
Saeid Daneshamouz ◽  
Soliman Mohammadi-Samani ◽  
Amirhossein Sakhteman ◽  
Golnaz Parhizkar ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Ph Sensitive ◽  
Water Soluble

scholarly journals Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 216 ◽  
Author(s):  
Ana Santos-Rebelo ◽  
Catarina Garcia ◽  
Carla Eleutério ◽  
Ana Bastos ◽  
Sílvia Castro Coelho ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Lines ◽  
Targeted Delivery ◽  
Water Soluble ◽  
Pancreatic Cell ◽  
Pharmaceutical Dosage Form ◽  
Alternative Approach ◽  
Water Soluble Compound ◽  
Efficient Alternative ◽  
Method Yield

Pancreatic cancer is the eighth leading cause of cancer death worldwide. For this reason, the development of more effective therapies is a major concern for the scientific community. Accordingly, plants belonging to Plectranthus genus and their isolated compounds, such as Parvifloron D, were found to have cytotoxic and antiproliferative activities. However, Parvifloron D is a very low water-soluble compound. Thus, nanotechnology can be a promising delivery system to enhance drug solubility and targeted delivery. The extraction of Parvifloron D from P. ecklonii was optimized through an acetone ultrasound-assisted method and isolated by Flash-Dry Column Chromatography. Then, its antiproliferative effect was selectivity evaluated against different tumor cell lines (IC50 of 0.15 ± 0.05 μM, 11.9 ± 0.7 μM, 21.6 ± 0.5, 34.3 ± 4.1 μM, 35.1 ± 2.2 μM and 32.1 ± 4.3 μM for BxPC3, PANC-1, Ins1-E, MCF-7, HaCat and Caco-2, respectively). To obtain an optimized stable Parvifloron D pharmaceutical dosage form, albumin nanoparticles were produced through a desolvation method (yield of encapsulation of 91.2%) and characterized in terms of size (165 nm; PI 0.11), zeta potential (−7.88 mV) and morphology. In conclusion, Parvifloron D can be efficiently obtained from P. ecklonii and it has shown selective cytotoxicity to pancreatic cell lines. Parvifloron D nanoencapsulation can be considered as a possible efficient alternative approach in the treatment of pancreatic cancer.

scholarly journals The Unique Protein-To-Protein Carotenoid Transfer Mechanism

2017 ◽  
Author(s):  
Eugene G. Maksimov ◽  
Nikolai N. Sluchanko ◽  
Yury B. Slonimskiy ◽  
Kirill S. Mironov ◽  
Konstantin E. Klementiev ◽  
...  
Keyword(s):  
Transfer Process ◽  
Targeted Delivery ◽  
Green Light ◽  
Water Soluble ◽  
Uncharacterized Protein ◽  
Water Soluble Protein ◽  
Orange Carotenoid Protein ◽  
Highly Hydrophobic

Orange Carotenoid Protein (OCP) is known to be an effector and regulator of cyanobacterial photoprotection. This 35 kDa water-soluble protein provides specific environment for keto-carotenoids, the excitation of which induced by the absorption of blue-green light causes dramatic but fully reversible rearrangements of the OCP structure, including carotenoid translocation and separation of C- and N-terminal domains upon transition from the basic orange to photoactivated red OCP form. While recent studies significantly improved our understanding of the OCP photocycle and interaction with phycobilisomes and the fluorescence recovery protein, the mechanism of OCP assembly remains unclear. Apparently, this process requires targeted delivery and incorporation of a highly hydrophobic carotenoid molecule into the water-soluble apoprotein of OCP. Recently, we introduced a novel carotenoid carrier protein, COCP, which consists of dimerized C-domain(s) of OCP and can combine with the isolated N-domain to form transient OCP-like species. Here, we demonstrate that in vitro COCP efficiently transfers otherwise tightly bound carotenoid to the full-length OCP apoprotein, resulting in formation of the photoactive OCP from completely photoinactive species. We accurately analyze peculiarities of this carotenoid transfer process which, to the best of our knowledge, seems unique, previously uncharacterized protein-to-protein carotenoid transfer process. We hypothesize that a similar OCP assembly can occur in vivo, substantiating specific roles of the COCP carotenoid carrier in cyanobacterial photoprotection.

Novel strategy for encapsulation and targeted delivery of poorly water‐soluble active substances

2020 ◽  
Vol 60 (8) ◽  
pp. 2008-2022
Author(s):  
Maja D. Markovic ◽  
Vesna V. Panic ◽  
Sanja I. Seslija ◽  
Ana D. Milivojevic ◽  
Pavle M. Spasojevic ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Water Soluble ◽  
Poorly Water Soluble ◽  
Novel Strategy ◽  
Active Substances

scholarly journals FORMULATION OF NANOPARTICLES OF TELMISARTAN INCORPORATED IN CARBOXYMETHYLCHITOSAN FOR THE BETTER DRUG DELIVERY AND ENHANCED BIOAVAILABILITY

2017 ◽  
Vol 10 (9) ◽  
pp. 236
Author(s):  
Upasana Yadav ◽  
Angshuman Ray Chowdhuri ◽  
Sumanta Kumar Sahu ◽  
Nuzhat Husain ◽  
Qamar Rehman
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Targeted Delivery ◽  
Drug Loading ◽  
Water Soluble ◽  
Bioavailability Enhancement ◽  
Water Soluble Drug ◽  
Efficient Option

  Objective: In this study, we have made an attempt to the developed formulation of nanoparticles (NPs) of telmisartan (TLM) incorporated in carboxymethyl chitosan (CMCS) for the better drug delivery and enhanced bioavailability.Materials and Methods: The NPs size and morphology were investigated by high-resolution transmission electron microscopy and field emission scanning electron microscopy, respectively. The crystal structures and surface functional groups were analyzed using X-ray diffraction pattern, and Fourier transform infrared spectroscopy, respectively.Results: To increase the solubility of TLM by targeted delivery of the drug through polymeric NPs is an alternative efficient, option for increasing the solubility. TLM nanosuspension powders were successfully formulated for dissolution and bioavailability enhancement of the drug. We focused on evaluating the influence of particle size and crystalline state on the in vitro and in vivo performance of TLM.Conclusion: In summary, we have developed a new approach toward the delivery of poorly water-soluble drug TLM by CMCS NPs. The particles having a good drug loading content and drug encapsulation efficiency. The cytotoxicity of the synthesized NPs is also very less.

A flexible yet wear-resistant co-citrate elastomer for on-demand disposable patch sensors

2020 ◽  
Vol 8 (29) ◽  
pp. 10047-10059 ◽  
Author(s):  
Do-Gwan Kim ◽  
Dowon Ahn ◽  
Kang-Han Kim ◽  
Yong-Cheol Jeong
Keyword(s):  
Wear Resistance ◽  
Strain Sensor ◽  
Metal Electrode ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Wear Resistant ◽  
On Demand

Herein, we report a wearable strain sensor, composed of a water-soluble metal electrode and a pH-sensitive encapsulation layer, with conforming flexibility and super wear-resistance.

pH-Sensitive Drug-Conjugates on Water-Soluble Polymer Frameworks

2014 ◽  
Vol 216 (3) ◽  
pp. 265-276 ◽  
Author(s):  
Abu Bakkar Siddique ◽  
Youngjun Cho ◽  
Yujin Kim ◽  
Sung Hoon Bahng ◽  
Sung Woo Kim ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Water Soluble ◽  
Soluble Polymer ◽  
Water Soluble Polymer ◽  
Drug Conjugates
Sign in / Sign up

Export Citation Format

Share Document