Graphene oxide as a pH-sensitive carrier for targeted delivery of eco-friendly corrosion inhibitors in chloride solution: Experimental and theroretical investigations

In this study, Typhonium giganteum containing dual-function nanofibers composed of poly(butylene carbonate), polylactic acid, and graphene oxide (PBC/PLA/GO) were successfully fabricated by electrospinning. The results from thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR) indicate that no interactions occurred between PBC and PLA. The nanofiber microstructure upon which graphene oxide was evenly distributed was studied by scanning electron microscopy (SEM) and showed good silk properties. The nanofibers can be used as a drug carrier since loaded Typhonium giganteum fibers possess excellent biocompatibility. Such nanofibers are effective in inhibiting the proliferation of A549 lung cancer cells, and thus they have potential for replacing chemotherapy-based treatments of lung cancer. In addition, the PBC/PLA/GO nanofibers degrade in physiological and natural environments, which is an important feature when engineering tissues and environment-friendly materials.

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pH-Sensitive graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel with improved mechanical strength

RSC Advances ◽

10.1039/c5ra19637j ◽

2015 ◽

Vol 5 (108) ◽

pp. 89083-89091 ◽

Cited By ~ 17

Author(s):

Huijuan Zhang ◽

Xianjuan Pang ◽

Yuan Qi

Keyword(s):

Graphene Oxide ◽

Mechanical Strength ◽

Sodium Alginate ◽

Ph Sensitive ◽

Swelling Behavior ◽

Ph Dependent

A pH-sensitive and mechanically strong graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel was designed and prepared. The composite semi-IPN hydrogel showed superior mechanical strength and pH-dependent swelling behavior.

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In-situ synthesis of Zn doped polyaniline on graphene oxide for inhibition of mild steel corrosion in 3.5 wt.% chloride solution

Journal of Industrial and Engineering Chemistry ◽

10.1016/j.jiec.2018.02.033 ◽

2018 ◽

Vol 63 ◽

pp. 322-339 ◽

Cited By ~ 39

Author(s):

Niloufar Notghi Taheri ◽

Bahram Ramezanzadeh ◽

Mohammad Mahdavian ◽

Ghasem Bahlakeh

Keyword(s):

Graphene Oxide ◽

Mild Steel ◽

Chloride Solution ◽

Steel Corrosion ◽

In Situ Synthesis ◽

Mild Steel Corrosion ◽

Doped Polyaniline

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Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

Nanotechnology Reviews ◽

10.1515/ntrev-2018-0029 ◽

2018 ◽

Vol 7 (4) ◽

pp. 291-301 ◽

Cited By ~ 16

Author(s):

Zepeng Jiao ◽

Bin Zhang ◽

Chunya Li ◽

Weicong Kuang ◽

Jingxian Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Graphene Oxide ◽

Drug Delivery System ◽

Delivery System ◽

Carboxymethyl Cellulose ◽

Drug Carrier ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

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