Microstructure, morphology, Physico‐chemical properties of nanocomposites containing hydroxyapatite/vivianite/graphene oxide for biomedical applications

Luminescence ◽  
2021 ◽  
Author(s):  
Mehrez E. El‐Naggar ◽  
Ola A. Abu Ali ◽  
Dalia I. Saleh ◽  
M. A. Abu‐Saied ◽  
M. K. Ahmed ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Physico Chemical ◽  
Microstructure Morphology

scholarly journals Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Epithelial Cells ◽  
Biomedical Applications ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Lateral Size ◽  
Human Lung Cells ◽  
Physico Chemical

Abstract Graphene derivatives (GD) are currently being evaluated for technological and biomedical applications owing to their unique physico-chemical properties over other carbon allotrope such as carbon nanotubes (CNTs). But, the possible association of their properties with underlying in vitro effects have not fully examined. Here, we assessed the comparative interaction of three GD - graphene oxide (GO), thermally reduced GO (TRGO) and chemically reduced GO (CRGO), which significantly differ in their lateral size and functional groups density, with phenotypically different human lung cells; bronchial epithelial cells (BEAS-2B) and alveolar epithelial cells (A549). The cellular studies demonstrate that GD significantly ineternalize and induce oxidative stress mediated cytotoxicity in both cells. The toxicity intensity was in line with the reduced lateral size and increased functional groups revealed more toxicity potential of TRGO and GO respectively. Further, A549 cells showed more susceptibility than BEAS-2B which reflected cell type dependent differential cellular response. Molecular studies revealed that GD induced differential cell death mechanism which was efficiently prevented by their respective inhibitors. This is prior study to the best of our knowledge involving TRGO for its safety evaluation which provided invaluable information and new opportunities for GD based biomedical applications.

scholarly journals How to Improve Physico-Chemical Properties of Silk Fibroin Materials for Biomedical Applications?—Blending and Cross-Linking of Silk Fibroin—A Review

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1510
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska
Keyword(s):  
Silk Fibroin ◽  
Biomedical Applications ◽  
Magnetic Particles ◽  
Chemical Properties ◽  
Ternary Mixtures ◽  
Cross Linking ◽  
Advantages And Disadvantages ◽  
Physico Chemical ◽  
Binary And Ternary Mixtures ◽  
To Receive

This review supplies a report on fresh advances in the field of silk fibroin (SF) biopolymer and its blends with biopolymers as new biomaterials. The review also includes a subsection about silk fibroin mixtures with synthetic polymers. Silk fibroin is commonly used to receive biomaterials. However, the materials based on pure polymer present low mechanical parameters, and high enzymatic degradation rate. These properties can be problematic for tissue engineering applications. An increased interest in two- and three-component mixtures and chemically cross-linked materials has been observed due to their improved physico-chemical properties. These materials can be attractive and desirable for both academic, and, industrial attention because they expose improvements in properties required in the biomedical field. The structure, forms, methods of preparation, and some physico-chemical properties of silk fibroin are discussed in this review. Detailed examples are also given from scientific reports and practical experiments. The most common biopolymers: collagen (Coll), chitosan (CTS), alginate (AL), and hyaluronic acid (HA) are discussed as components of silk fibroin-based mixtures. Examples of binary and ternary mixtures, composites with the addition of magnetic particles, hydroxyapatite or titanium dioxide are also included and given. Additionally, the advantages and disadvantages of chemical, physical, and enzymatic cross-linking were demonstrated.

scholarly journals Tuning Properties of Partially Reduced Graphene Oxide Fibers upon Calcium Doping

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 957 ◽  
Author(s):  
Krzysztof Tadyszak ◽  
Jacek K. Wychowaniec ◽  
Karol Załęski ◽  
Emerson Coy ◽  
Łukasz Majchrzycki ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Chemical Properties ◽  
Fiber Axis ◽  
Paramagnetic Resonance ◽  
Physico Chemical ◽  
Reduced Graphene ◽  
Calcium Doping ◽  
Bulk Structures ◽  
Pulsed Electron Paramagnetic Resonance ◽  
Electron Paramagnetic

The arrangement of two-dimensional graphene oxide sheets has been shown to influence physico-chemical properties of the final bulk structures. In particular, various graphene oxide microfibers remain of high interest in electronic applications due to their wire-like thin shapes and the ease of hydrothermal fabrication. In this research, we induced the internal ordering of graphene oxide flakes during typical hydrothermal fabrication via doping with Calcium ions (~6 wt.%) from the capillaries. The Ca2+ ions allowed for better graphene oxide flake connections formation during the hydrogelation and further modified the magnetic and electric properties of structures compared to previously studied aerogels. Moreover, we observed the unique pseudo-porous fiber structure and flakes connections perpendicular to the long fiber axis. Pulsed electron paramagnetic resonance (EPR) and conductivity measurements confirmed the denser flake ordering compared to previously studied aerogels. These studies ultimately suggest that doping graphene oxide with Ca2+ (or other) ions during hydrothermal methods could be used to better control the internal architecture and thus tune the properties of the formed structures.

scholarly journals Graphene and its derivatives as biomedical materials: future prospects and challenges

2018 ◽  
Vol 8 (3) ◽  
pp. 20170056 ◽  
Author(s):  
Arghya Narayan Banerjee
Keyword(s):  
Tissue Engineering ◽  
Cell Culture ◽  
Graphene Oxide ◽  
Cell Growth ◽  
Drug Loading ◽  
Chemical Properties ◽  
Culture Cell ◽  
Biomedical Materials ◽  
Physico Chemical ◽  
Bio Imaging

Graphene and its derivatives possess some intriguing properties, which generates tremendous interests in various fields, including biomedicine. The biomedical applications of graphene-based nanomaterials have attracted great interests over the last decade, and several groups have started working on this field around the globe. Because of the excellent biocompatibility, solubility and selectivity, graphene and its derivatives have shown great potential as biosensing and bio-imaging materials. Also, due to some unique physico-chemical properties of graphene and its derivatives, such as large surface area, high purity, good bio-functionalizability, easy solubility, high drug loading capacity, capability of easy cell membrane penetration, etc., graphene-based nanomaterials become promising candidates for bio-delivery carriers. Besides, graphene and its derivatives have also shown interesting applications in the fields of cell-culture, cell-growth and tissue engineering. In this article, a comprehensive review on the applications of graphene and its derivatives as biomedical materials has been presented. The unique properties of graphene and its derivatives (such as graphene oxide, reduced graphene oxide, graphane, graphone, graphyne, graphdiyne, fluorographene and their doped versions) have been discussed, followed by discussions on the recent efforts on the applications of graphene and its derivatives in biosensing, bio-imaging, drug delivery and therapy, cell culture, tissue engineering and cell growth. Also, the challenges involved in the use of graphene and its derivatives as biomedical materials are discussed briefly, followed by the future perspectives of the use of graphene-based nanomaterials in bio-applications. The review will provide an outlook to the applications of graphene and its derivatives, and may open up new horizons to inspire broader interests across various disciplines.

Synthesis, physico-chemical properties and biomedical applications of poly(amidoamine)s

Polymer ◽  
1985 ◽  
Vol 26 (9) ◽  
pp. 1336-1348 ◽  
Author(s):  
Paolo Ferruti ◽  
Maria Antonietta Marchisio ◽  
Rolando Barbucci
Keyword(s):  
Biomedical Applications ◽  
Chemical Properties ◽  
Physico Chemical

scholarly journals Self-Assembling Peptides and Carbon Nanomaterials Join Forces for Innovative Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4084
Author(s):  
Petr Rozhin ◽  
Costas Charitidis ◽  
Silvia Marchesan
Keyword(s):  
Carbon Nanostructures ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Chemical Properties ◽  
Building Blocks ◽  
Research Areas ◽  
Self Assembling ◽  
Concise Review ◽  
Physico Chemical ◽  
Great Progress

Self-assembling peptides and carbon nanomaterials have attracted great interest for their respective potential to bring innovation in the biomedical field. Combination of these two types of building blocks is not trivial in light of their very different physico-chemical properties, yet great progress has been made over the years at the interface between these two research areas. This concise review will analyze the latest developments at the forefront of research that combines self-assembling peptides with carbon nanostructures for biological use. Applications span from tissue regeneration, to biosensing and imaging, and bioelectronics.

Synthesis, Physico-Chemical Properties, and Biomedical Applications of Gold Nanorods—A Review

2016 ◽  
Vol 12 (6) ◽  
pp. 1136-1158 ◽  
Author(s):  
ValeriaS. Marangoni ◽  
Juliana Cancino-Bernardi ◽  
Valtencir Zucolotto
Keyword(s):  
Gold Nanorods ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Physico Chemical

Chemo-physical Properties and Biomedical Applications of Hyaluronic Acid in Medicine

2017 ◽  
Vol 68 (2) ◽  
pp. 384-386 ◽  
Author(s):  
Danut Vasile ◽  
Raluca Iancu ◽  
Camelia Bogdanici ◽  
Emil Ungureanu ◽  
Dana Ciobotea ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Elastic Behavior ◽  
Current Evidence ◽  
Hydroxyl Groups ◽  
Carboxylate Group ◽  
Medical Problems ◽  
Physico Chemical

Hyaluronic acid is a mucopolysaccharide encountered in most body fluids and extracellular matrix. The aim of our review is to summarize current evidence about chemico-physical properties of hyaluronic acid, highlighting biomedical applications of hyaluronan derivatives. It is a glycosaminoglycan made of repeating disaccharide units containing a carboxylate group, four hydroxyl groups and one carboxylate group, with hydrophilic properties. Its particular structure with multiple coils forming an entangled network results in unique pseudoplastic and viscoelastic characteristics. Its viscous and elastic behavior, depending on the applied strain, makes hyaluronan widely applicable in biomedical field. The large amount of functions and applications is determined by the physico-chemical properties, which allows a polymorphism of the hyaluronic acid structures depending on the molecular weight variations, concentration and ionic status. It is currently used in ophthalmology, orthopedics and rheumatology, in plastic surgery, surgery and otolaryngology as well. Already widely used in clinical practice, hyaluronic acid proves to be often the best solution for difficult medical problems. Future developments in nanomedicine and drug delivery linked to hyaluronic acid are emerging.

scholarly journals Author Correction: Physico-chemical properties based differential toxicity of graphene oxide/reduced graphene oxide in human lung cells mediated through oxidative stress

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Sandeep Mittal ◽  
Veeresh Kumar ◽  
Nitesh Dhiman ◽  
Lalit Kumar Singh Chauhan ◽  
Renu Pasricha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Human Lung ◽  
Chemical Properties ◽  
Lung Cells ◽  
Human Lung Cells ◽  
Physico Chemical ◽  
Differential Toxicity ◽  
Reduced Graphene
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