Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health

Biologically active plant-based compounds, commonly referred to as phytochemicals, can influence the expression and function of various receptors and transcription factors or signaling pathways that play vital roles in cellular functions and are then involved in human health and diseases. Thus, phytochemicals may have a great potential to prevent and treat chronic diseases. Glyceollins, a group of phytoalexins that are isolated from soybeans, have attracted attention because they exert numerous effects on human functions and diseases, notably anticancer effects. In this review, we have presented an update on the effects of glyceollins in relation to their potential beneficial roles in human health. Despite a growing number of studies suggesting that this new family of phytochemicals can be involved in critical cellular pathways, such as estrogen receptor, protein kinase, and lipid kinase signaling pathways, future investigations will be needed to better understand their molecular mechanisms and their specific significance in biomedical applications.

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Mitochondrial Iron in Human Health and Disease

Annual Review of Physiology ◽

10.1146/annurev-physiol-020518-114742 ◽

2019 ◽

Vol 81 (1) ◽

pp. 453-482 ◽

Cited By ~ 14

Author(s):

Diane M. Ward ◽

Suzanne M. Cloonan

Keyword(s):

Human Health ◽

Mammalian Cells ◽

Molecular Mechanisms ◽

Innate Immune ◽

Biological Functions ◽

Mitochondrial Homeostasis ◽

Innate Immune Signaling ◽

Mitochondrial Iron ◽

Health And Disease

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria encompass an active organellar network that fuses, divides, and directs a myriad of vital biological functions, including energy metabolism, cell death regulation, and innate immune signaling in different tissues. Another crucial and often underappreciated function of these dynamic organelles is their central role in the metabolism of the most abundant and biologically versatile transition metals in mammalian cells, iron. In recent years, cellular and animal models of mitochondrial iron dysfunction have provided vital information in identifying new proteins that have elucidated the pathways involved in mitochondrial homeostasis and iron metabolism. Specific signatures of mitochondrial iron dysregulation that are associated with disease pathogenesis and/or progression are becoming increasingly important. Understanding the molecular mechanisms regulating mitochondrial iron pathways will help better define the role of this important metal in mitochondrial function and in human health and disease.

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Abstract 1270: Potential metabolic and molecular mechanisms of black raspberry-mediated oral cancer chemoprevention

10.1158/1538-7445.am2018-1270 ◽

2018 ◽

Author(s):

Steve Oghumu ◽

Thomas J. Knobloch ◽

Logan C. Weghorst ◽

Lei Bruschweiler-Li ◽

Cheng Wang ◽

...

Keyword(s):

Oral Cancer ◽

Molecular Mechanisms ◽

Cancer Chemoprevention ◽

Black Raspberry

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Dietary Components, Microbial Metabolites and Human Health: Reading between the Lines

Foods ◽

10.3390/foods9081045 ◽

2020 ◽

Vol 9 (8) ◽

pp. 1045

Author(s):

Yao Guo ◽

Xiaohan Bian ◽

Jiali Liu ◽

Ming Zhu ◽

Lin Li ◽

...

Keyword(s):

Linoleic Acid ◽

Gut Microbiota ◽

Human Health ◽

Kynurenic Acid ◽

Molecular Mechanisms ◽

Eating Habits ◽

Short Chain Fatty Acids ◽

Human Gut ◽

Dietary Components ◽

Host Metabolism

Trillions of bacteria reside in the human gut and they metabolize dietary substances to obtain nutrients and energy while producing metabolites. Therefore, different dietary components could affect human health in various ways through microbial metabolism. Many such metabolites have been shown to affect human physiological activities, including short-chain fatty acids metabolized from carbohydrates; indole, kynurenic acid and para-cresol, metabolized from amino acids; conjugated linoleic acid and linoleic acid, metabolized from lipids. Here, we review the features of these metabolites and summarize the possible molecular mechanisms of their metabolisms by gut microbiota. We discuss the potential roles of these metabolites in health and diseases, and the interactions between host metabolism and the gut microbiota. We also show some of the major dietary patterns around the world and hope this review can provide insights into our eating habits and improve consumers’ health conditions.

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Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer

The AAPS Journal ◽

10.1208/s12248-013-9486-2 ◽

2013 ◽

Vol 15 (3) ◽

pp. 707-716 ◽

Cited By ~ 48

Author(s):

Harold Ting ◽

Gagan Deep ◽

Rajesh Agarwal

Keyword(s):

Prostate Cancer ◽

Molecular Mechanisms ◽

Cancer Chemoprevention ◽

Major Emphasis

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Nutraceuticals for prostate cancer chemoprevention: from molecular mechanisms to clinical application

Expert Opinion on Investigational Drugs ◽

10.1517/13543784.2013.833183 ◽

2013 ◽

Vol 22 (12) ◽

pp. 1613-1626 ◽

Cited By ~ 21

Author(s):

Zhijun Wang ◽

Jeffery Fan ◽

Mandy Liu ◽

Steven Yeung ◽

Andy Chang ◽

...

Keyword(s):

Prostate Cancer ◽

Clinical Application ◽

Molecular Mechanisms ◽

Cancer Chemoprevention

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New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals:In VitroandIn VivoStudies and the Underlying Mechanisms

BioMed Research International ◽

10.1155/2014/243452 ◽

2014 ◽

Vol 2014 ◽

pp. 1-18 ◽

Cited By ~ 28

Author(s):

Madhulika Singh ◽

Shankar Suman ◽

Yogeshwer Shukla

Keyword(s):

Skin Cancer ◽

Cell Cycle Progression ◽

Molecular Mechanisms ◽

Cancer Chemoprevention ◽

Chemopreventive Agents ◽

Novel Approach ◽

Comprehensive Knowledge ◽

Underlying Mechanisms

Skin cancer is still a major cause of morbidity and mortality worldwide. Skin overexposure to ultraviolet irradiations, chemicals, and several viruses has a capability to cause severe skin-related disorders including immunosuppression and skin cancer. These factors act in sequence at various steps of skin carcinogenesis via initiation, promotion, and/or progression. These days cancer chemoprevention is recognized as the most hopeful and novel approach to prevent, inhibit, or reverse the processes of carcinogenesis by intervention with natural products. Phytochemicals have antioxidant, antimutagenic, anticarcinogenic, and carcinogen detoxification capabilities thereby considered as efficient chemopreventive agents. Considerable efforts have been done to identify the phytochemicals which may possibly act on one or several molecular targets that modulate cellular processes such as inflammation, immunity, cell cycle progression, and apoptosis. Till date several phytochemicals in the light of chemoprevention have been studied by using suitable skin carcinogenicin vitroandin vivomodels and proven as beneficial for prevention of skin cancer. This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer.

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