For sexually active women, do topical microbicides prevent sexually transmitted infections (STIs)?

2021 ◽  
Author(s):  
Edith Angel-Müller

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S212-S213
Author(s):  
Timothy William. Menza ◽  
Lauren Lipira ◽  
Amisha Bhattarai ◽  
Joseph Ramirez ◽  
Roberto Orellana

Abstract Background Rectal gonorrhea and Chlamydia are common and predict HIV acquisition among men who have sex with men (MSM); however, screening for rectal sexually transmitted infections (STIs) is not routine. Methods In 2017, we recruited sexually-active MSM in the Portland, Oregon metropolitan area through venue-based sampling. Our outcome of interest was self-reported rectal STI screening in the prior 12 months. Stratified by HIV status, we assessed the prevalence and demographic, healthcare, clinical, and behavioral predictors of screening. Results Of 448 participants, 168 (37.5%) reported rectal STI screening. One hundred twenty-seven (35.8%) of 355 HIV-negative men, 41 (58.6%) of 70 HIV-positive men, and none of 23 men who did not know their HIV status reported screening. Among HIV-negative men, having a healthcare provider who offered HIV testing (adjusted prevalence ratio [aPR]=2.09; 95% confidence interval [CI]: 1.43, 3.04), a syphilis diagnosis (aPR=1.32; 95% CI: 1.03, 1.69), use of pre-exposure prophylaxis (aPR=1.57; 95% CI 1.21, 2.04), and condomless anal sex with casual partners in the prior 12 months (aPR=1.74; 95% CI: 1.36, 2.22) independently predicted screening for rectal STI in multivariable analysis. HIV-positive men who reported having a provider who always or often initiates conversations about sex were significantly more likely to report screening compared with men who did not have such a provider (aPR=1.48; 95% CI: 1.06, 2.06). Conclusion Rectal STI screening is not universal in a venue-based sample of sexually-active MSM. Implementing innovative, acceptable, and accessible screening practices and improving provider comfort with talking about sex are paramount to increasing rectal STI screening. Disclosures All authors: No reported disclosures.





2013 ◽  
Vol 7 (12) ◽  
pp. 966-974 ◽  
Author(s):  
Dangui Zhang ◽  
Hui Pan ◽  
Binglin Cui ◽  
Frieda Law ◽  
Jeremy Farrar ◽  
...  

Introduction: This study investigated the current state of attitudes, behaviors, and knowledge concerning sex and sexually transmitted infections (STIs) among Chinese university students. Methodology: A cross-sectional anonymous university intranet-based survey was given to students attending the Shantou University, Guangdong, China using a 28-item questionnaire. Results: Of 3425 website visitors, 1030 university students completed the survey, of which 80% were between 20 and 25 years of age, 76% considered pre-marital sex acceptable, 21% had had sexual intercourse, and 45% of sexually active students had engaged in oral sex, anal intercourse, or sex with strangers. Students had limited knowledge and awareness about common STIs, symptoms, and complications. Three percent of the sexually active students reported having had STIs and another 8% were not sure whether they had or not. Most students had misconceptions about transmission and prevention of STIs. The internet was the main information resource for 76% of students. Conclusions: Despite having more open attitudes and behaviors towards sex, students’ STI knowledge and awareness of STI risks was considerably limited, raising concerns about a likely rise in STI incidence. Prior knowledge of STIs had no significant influence. Targeted educational measures such as online education and counseling via Chinese websites and social media, and the provision of safer sex and STI-related information by health experts to university students are suggested.



2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Martin Kuete ◽  
Qiao Huang ◽  
Abid Rashid ◽  
Xiu Lan Ma ◽  
HongFang Yuan ◽  
...  

Although the prevalence of human immunodeficiency virus (HIV) decreased in the last decade worldwide, the number of deaths due to HIV/AIDS and communicable diseases including syphilis, hepatitis, and tuberculosis had dramatically increased in developing countries. Education and behavior are incredibly important factors to prevent these diseases’ spread. This study highlights the range of differences in knowledge, attitude, and behavior of 434 sexually active medical students towards HIV/AIDS and sexually transmitted infections (STIs). Because the surveyed population constitutes the forefront of healthcare providers and was originated from different area of the world, this is the first time a study sought to investigate the behavioral attitude of this group of population irrespective of the three levels of their academic and professional knowledge. Several factors including sociodemographic characteristics, sexual behavior, HIV/AIDS, and STIs related patterns play a key role in medical student attitude and behavior towards people infected with HIV/AIDS and STIs. Our findings add consistent value in prior studies which aimed to stop new infections and also imply further investigations on the management of the studied infections by medical students. The present study arouses much interest among participants and provides evidence of reinforcing medical students’ education on HIV/AIDS and STIs.



2020 ◽  
Author(s):  
Veronicah Masanja ◽  
Solomon Tsebeni Wafula ◽  
Tonny Ssekamatte ◽  
John Bosco Isunju ◽  
Richard K Mugambe ◽  
...  

Abstract Background: Female adolescents and young women have the highest risk of curable sexually transmitted infections (STIs) globally. Data on the prevalence of STIs among young women in Uganda are limited. In this study, we investigated the time trends and determinants of STIs among adolescent girls and young women (15-24 years) in Uganda. Methods: We estimated the percentage of women 15-24 years from three recent consecutive Uganda Demographic and Health Surveys (2006, 2011, and 2016), who reported acquiring an STI within 12 months of the studies and examined the changes over time. A pooled multivariable logistic regression was used to examine predictors of actors associated with reporting an STI were assessed using.Results: The pooled STI prevalence was 26.0%. About 22.0% of youths reported an STI in 2006. This increased to 36.3% in 2011, before declining to 23.1% in 2016. Youths aged 20-24 years reported a higher STI prevalence (27.3%) compared to young participants (23.6%). Prevalence of STIs was significantly higher among female youths with multiple total lifetime partners (adjusted odds ratio (aOR 1.6, 95% CI 1.4-1.6). Similarly, women who were sexually active in the last 4 weeks prior to the interview (aOR 1.3, 95% CI 1.1-1.6), and women affiliated to Islam (aOR 1.3, 95% CI 1.1-1.6) or other religions (aOR 1.8, 95% CI 1.1-2.9) were more likely to report an STI. Living in Northern Uganda was found protective against STIs (aOR 0.5, 95% CI 0.3-0.7).Conclusion: The prevalence of STIs was high among female youths, 15-24 years. There is a need to adopt a holistic approach to the diagnosis and management of STIs among youths, as well as the integration of STI services in daily health care systems to increase their access to sexual and reproductive health services.



2021 ◽  
Vol 54 (suppl 1) ◽  
Author(s):  
Maria Alix Leite Araujo ◽  
Juliana Uesono ◽  
Nádia Maria da Silva Machado ◽  
Valdir Monteiro Pinto ◽  
Eliana Amaral


2021 ◽  
Vol 2 (3) ◽  
pp. 340-352
Author(s):  
Andrea Karime González Silva ◽  
Nadia Velázquez Hernández ◽  
Alma Rosa Pérez Álamos ◽  
Marisela Aguilar Durán

La tricomoniasis representa el 30% de las infecciones de transmisión sexual no virales en el mundo; su agente etiológico es el protozoario parásito Trichomonas vaginalis. Frecuentemente la infección es asintomática, lo que dificulta su tratamiento y detección y facilita su transmisión. La implementación de pruebas específicas, sensibles y económicamente accesibles que permitan mejorar la capacidad de detección de este patógeno, es importante ya que los métodos de diagnóstico que se utilizan tradicionalmente (examen en fresco, cultivo vaginal, papanicolaou, etc.) no cumplen con estos requisitos. En este proyecto se incluyeron 197 mujeres sexualmente activas entre los 17 y los 67 años; se tomaron muestras cérvicovaginales para realizar examen en fresco, tinción Papanicolaou y para la identificación molecular se amplificó una región conservada en el gen de adhesina AP65 de T. vaginalis. Se obtuvo una prevalencia del 35.5% de Trichomonas vaginalis identificada por de PCR de punto final, confirmando que esta última es la técnica con mayor sensibilidad y especificidad con respecto al examen en fresco y Papanicolaou.   Trichomoniasis represents 30% of non-viral sexually transmitted infections worldwide; its etiological agent is the protozoan parasite Trichomonas vaginalis. The infection is often asymptomatic, which makes it difficult to treat and detect and facilitates its transmission. The implementation of specific, sensitive and economically accessible tests to improve the detection capacity of this pathogen is important because the diagnostic methods traditionally used (fresh examination, vaginal culture, pap smears, etc.) do not meet these requirements. 197 sexually active women between 17 and 67 years of age were included in this project; cervicovaginal samples were taken for fresh test, Papanicolaou staining, and for molecular identification, a conserved region in the AP65 adhesin gene of T. vaginalis was amplified. A prevalence of 35.5% of Trichomonas vaginalis identified by end-point PCR was obtained, confirming that the latter is the technique with greater sensitivity and specificity with respect to the fresh test and Papanicolaou.



2021 ◽  
Author(s):  
Veronicah Masanja ◽  
Solomon Tsebeni Wafula ◽  
Tonny Ssekamatte ◽  
John Bosco Isunju ◽  
Richard K Mugambe ◽  
...  

Abstract Background: Female adolescents and young women have the highest risk of curable sexually transmitted infections (STIs) globally. Data on the prevalence of STIs among young women in Uganda are limited. In this study, we investigated the time trends and correlates of STIs among adolescent girls and young women (15-24 years) in Uganda.Methods: We estimated the percentage of women 15-24 years from three recent consecutive Uganda Demographic and Health Surveys (2006, 2011, and 2016), who reported suffering from genital sores, and or genital discharge or any other varginal complaints acquired after sexual intercourse within 12 months of the studies and examined the changes over time. A pooled multivariable logistic regression was used to examine the correlates of reporting an STI in the last 12 months preceding the study. Svyset command in Stata was used to cater for the survey sample design.Results: The pooled self-reported STI prevalence was 26.0%. Among these young women, 22.0%, 36.3%, and 23.1% reported a sexually transmitted infection in 2006, 2011, and 2016 respectively. Between 2006 and 2011, there was evidence of change (+14.3%, p < 0.001) in STI prevalence before a significant reduction (-12.0%, p<0.001). Youths aged 20-24 years reported a higher STI prevalence (27.3%) compared to young participants (23.6%). Correlates of reporting an STI among rural and urban young women were: having multiple total lifetime partners (adjusted odds ratio (aOR 1.6, 95% CI 1.4-1.6), being sexually active in the last 4 weeks (aOR 1.3, 95% CI 1.1-1.6), and being affiliated to Muslim faith (aOR 1.3, 95% CI 1.1-1.6) or other religions (aOR 1.8, 95% CI 1.1-2.9) as compared to Christian were more likely to report an STI. Living in Northern Uganda compared to living in Kampala city was found protective against STIs (aOR 0.5, 95% CI 0.3-0.7).Conclusion: The prevalence of STIs was high among female youths, 15-24 years. This highlights the need for a comprehensive STIs screening, surveillance, and treatment programme to potentially reduce the burden of STIs in the country.



2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Abdul-Aziz Seidu ◽  
Bright Opoku Ahinkorah ◽  
Louis Kobina Dadzie ◽  
Justice Kanor Tetteh ◽  
Ebenezer Agbaglo ◽  
...  

Abstract Background Despite the importance of self-reporting health in sexually transmitted infections (STIs) control, studies on self-reported sexually transmitted infections (SR-STIs) are scanty, especially in sub-Saharan Africa (SSA). This study assessed the prevalence and factors associated with SR-STIs among sexually active men (SAM) in SSA. Methods Analysis was done based on the current Demographic and Health Survey of 27 countries in SSA conducted between 2010 and 2018. A total of 130,916 SAM were included in the analysis. The outcome variable was SR-STI. Descriptive and inferential statistics were performed with a statistical significance set at p < 0.05. Results On the average, the prevalence of STIs among SAM in SSA was 3.8%, which ranged from 13.5% in Liberia to 0.4% in Niger. Sexually-active men aged 25–34 (AOR = 1.77, CI:1.6–1.95) were more likely to report STIs, compared to those aged 45 or more years. Respondents who were working (AOR = 1.24, CI: 1.12–1.38) and those who had their first sex at ages below 20 (AOR = 1.20, CI:1.11–1.29) were more likely to report STIs, compared to those who were not working and those who had their first sex when they were 20 years and above. Also, SAM who were not using condom had higher odds of STIs (AOR = 1.35, CI: 1.25–1.46), compared to those who were using condom. Further, SAM with no comprehensive HIV and AIDS knowledge had higher odds (AOR = 1.43, CI: 1.08–1.22) of STIs, compared to those who reported to have HIV/AIDS knowledge. Conversely, the odds of reporting STIs was lower among residents of rural areas (AOR = 0.93, CI: 0.88–0.99) compared to their counterparts in urban areas, respondents who had no other sexual partner (AOR = 0.32, CI: 0.29–0.35) compared to those who had 2 or more sexual partners excluding their spouses, those who reported not paying for sex (AOR = 0.55, CI: 0.51–0.59) compared to those who paid for sex, and those who did not read newspapers (AOR = 0.93, CI: 0.86–0.99) compared to those who read. Conclusion STIs prevalence across the selected countries in SSA showed distinct cross-country variations. Current findings suggest that STIs intervention priorities must be given across countries with high prevalence. Several socio-demographic factors predicted SR-STIs. To reduce the prevalence of STIs among SAM in SSA, it is prudent to take these factors (e.g., age, condom use, employment status, HIV/AIDS knowledge) into consideration when planning health education and STIs prevention strategies among SAM.



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