Back Cover: Isolation, Biological Activity Evaluation, Structure Elucidation, and Total Synthesis of Eliamid: A Novel Complex I Inhibitor (Chem. Eur. J. 36/2012)

Little attention has been paid to the bryophytes for use in the human diet in spite of the presence of 23,000 species in the world. Some liverworts produce lipophilic terpenoids and phenolic bis-bibenzyls, possessing antimicrobial, antifungal, antiviral, cytotoxic, anti-oxidant, muscle relaxing, and antiobesity activities. In this review, the isolation, structures elucidation, bio- and total syntheses of bis-bibenzyls from several liverworts are discussed.

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Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation

Organic & Biomolecular Chemistry ◽

10.1039/c8ob02713g ◽

2018 ◽

Vol 16 (47) ◽

pp. 9138-9142 ◽

Cited By ~ 3

Author(s):

Gorakhnath R. Jachak ◽

Paresh R. Athawale ◽

Heena Agarwal ◽

Manoj Kumar Barthwal ◽

Gianluigi Lauro ◽

...

Keyword(s):

Biological Activity ◽

Total Synthesis ◽

Natural Product ◽

Structural Revision ◽

Activity Evaluation ◽

Anti Inflammatory ◽

First Time

Herein, we report the total synthesis of solomonamide A along with its structural revision for the first time.

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Neocryptolepine: A Promising Indoloisoquinoline Alkaloid with Interesting Biological Activity. Evaluation of the Drug and its Most Relevant Analogs

Current Topics in Medicinal Chemistry ◽

10.2174/1568026615666150427113937 ◽

2015 ◽

Vol 15 (17) ◽

pp. 1683-1707 ◽

Cited By ~ 14

Author(s):

Enrique Larghi ◽

Andrea Bracca ◽

Abel Arroyo Aguilar ◽

Daniel Heredia ◽

Jorgelina Pergomet ◽

...

Keyword(s):

Biological Activity ◽

Activity Evaluation

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New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity

Marine Drugs ◽

10.3390/md19010035 ◽

2021 ◽

Vol 19 (1) ◽

pp. 35

Author(s):

Mohamed Shaaban ◽

Ghada S. E. Abou-El-Wafa ◽

Christopher Golz ◽

Hartmut Laatsch

Keyword(s):

Biological Activity ◽

Crude Extract ◽

Structure Elucidation ◽

Antimicrobial Activities ◽

Red Alga ◽

Spectroscopic Methods ◽

X Ray Diffraction ◽

X Ray ◽

Chemical Structures ◽

Terpene Derivatives

Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.

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Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity

Natural Product Reports ◽

10.1039/d1np00007a ◽

2021 ◽

Author(s):

Robert M. Hohlman ◽

David H. Sherman

Keyword(s):

Biological Activity ◽

Total Synthesis ◽

Indole Alkaloids ◽

Recent Advances

This review covers isolation, biological activity, an overview of total synthesis efforts and recent biosynthetic discoveries related to hapalindole-type indole alkaloids.

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Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

Natural Product Communications ◽

10.1177/1934578x1100601110 ◽

2011 ◽

Vol 6 (11) ◽

pp. 1934578X1100601

Author(s):

Karsten Krohn ◽

Stephan Cludius-Brandt ◽

Barbara Schulz ◽

Mambatta Sreelekha ◽

Pottachola Mohamed Shafi

Keyword(s):

Biological Activity ◽

Carboxylic Acid ◽

Medicinal Plant ◽

Plant Extract ◽

Structure Elucidation ◽

Biologically Active ◽

Reduction Product ◽

Pharmacological Properties ◽

Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

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The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

Royal Society Open Science ◽

10.1098/rsos.172317 ◽

2018 ◽

Vol 5 (6) ◽

pp. 172317 ◽

Cited By ~ 1

Author(s):

Chang K. Zhao ◽

Chan Li ◽

Xian H. Wang ◽

Yu J. Bao ◽

Fu H. Yang ◽

...

Keyword(s):

Biological Activity ◽

Cell Growth ◽

Cancer Treatment ◽

Cancer Cell ◽

Therapeutic Potential ◽

Selective Synthesis ◽

Cancer Cell Growth ◽

Activity Evaluation ◽

Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

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