scholarly journals The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity

2017 ◽  
Vol 12 (8) ◽  
pp. 1934578X1701200
Author(s):  
Yoshinori Asakawa
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Structure Elucidation ◽  
Human Diet ◽  
Total Syntheses ◽  
The World ◽  
Anti Oxidant

Little attention has been paid to the bryophytes for use in the human diet in spite of the presence of 23,000 species in the world. Some liverworts produce lipophilic terpenoids and phenolic bis-bibenzyls, possessing antimicrobial, antifungal, antiviral, cytotoxic, anti-oxidant, muscle relaxing, and antiobesity activities. In this review, the isolation, structures elucidation, bio- and total syntheses of bis-bibenzyls from several liverworts are discussed.

Isolation, Synthesis, and Biological Activity of Quindoline, a Valuable­ Indoloquinoline Natural Product and Useful Key Intermediate­

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1417-1429 ◽  
Author(s):  
Teodoro Kaufman ◽  
María Méndez ◽  
Andrea Bracca
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Natural Product ◽  
Natural Source ◽  
Total Syntheses ◽  
Naturally Occurring ◽  
The World ◽  
Biological Tests ◽  
Synthetic Studies

Quindoline is one of the simplest naturally occurring monomeric indoloquinoline alkaloids. Chemists exhibited interest in this compound before it was isolated from a natural source. The different approaches toward the total synthesis of the natural product and its performance in various biological tests are discussed. Aspects related to the isolation of quindoline from different ethnomedicinally relevant plants around the world are also reviewed.1 Introduction2 Isolation and Biogenetic Considerations3 Total Syntheses of Quindoline3.1 Early Synthetic Studies3.2 Syntheses from Benzenoids3.3 Syntheses from Indoles3.4 Syntheses from Quinolines4 Biological Activity Studies5 Conclusions

Isolation, Biological Activity Evaluation, Structure Elucidation, and Total Synthesis of Eliamid: A Novel Complex I Inhibitor

2012 ◽  
Vol 18 (36) ◽  
pp. 11362-11370 ◽  
Author(s):  
Gerhard Höfle ◽  
Klaus Gerth ◽  
Hans Reichenbach ◽  
Brigitte Kunze ◽  
Florenz Sasse ◽  
...  
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Complex I ◽  
Structure Elucidation ◽  
Activity Evaluation ◽  
Novel Complex

scholarly journals Stemarane Diterpenes and Diterpenoids

2019 ◽  
Vol 20 (11) ◽  
pp. 2627 ◽  
Author(s):  
Francesca Leonelli ◽  
Alessio Valletta ◽  
Luisa Maria Migneco ◽  
Rinaldo Marini Bettolo
Keyword(s):  
Biological Activity ◽  
Structure Elucidation ◽  
Scientific Activity ◽  
Natural Sources ◽  
The World

In this article the scientific activity carried out on stemarane diterpenes and diterpenoids, isolated over the world from various natural sources, was reviewed. The structure elucidation of stemarane diterpenes and diterpenoids was reported, in addition to their biogenesis and biosynthesis. Stemarane diterpenes and diterpenoids biotransformations and biological activity was also taken into account. Finally the work leading to the synthesis and enantiosynthesis of stemarane diterpenes and diterpenoids was described.

Synthesis of Optically Active N-(4-Hydroxynon-2-enyl)pyrrolidines: Key Building Blocks in the Total Synthesis of Streptomyces coelicolor Butanolide 5 (SCB-5) and Virginiae Butanolide A (VB-A)

Synthesis ◽  
2021 ◽  
Author(s):  
Udo Nubbemeyer ◽  
Jonas Donges ◽  
Sandra Hofmann ◽  
Johannes C. Walter ◽  
Julia Reichertz ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Structure Elucidation ◽  
High Selectivity ◽  
Streptomyces Coelicolor ◽  
Building Blocks ◽  
Optically Active ◽  
Hplc Separation ◽  
Total Syntheses ◽  
Diastereoselective Reduction ◽  
Allyl Alcohols

AbstractStarting from 5-methylhexanal and (S)-configured N-propargylprolinol ethers, coupling delivered N-(4-hydroxynon-2-ynyl)prolinol derivatives as mixtures of C4 diastereomers. Resolution of the epimers succeeded after introduction of an (R)-mandelic ester derivative and subsequent HPLC separation. Alternatively, suitable oxidation gave the corresponding alkynyl ketone. Midland reagent controlled diastereoselective reduction afforded a defined configured propargyl alcohol with high selectivity. LiAlH4 reduction and Mosher analyses of the allyl alcohols enabled structure elucidation. The suitably protected products are used as key intermediates in enantioselective Streptomyces γ-butyrolactone signaling molecule total syntheses.

scholarly journals Advances in the Total Synthesis of Aflatoxins

2021 ◽  
Vol 9 ◽  
Author(s):  
Liyan Yang ◽  
Zhonglei Wang
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Human Health ◽  
Food Industry ◽  
Aspergillus Parasiticus ◽  
Asymmetric Syntheses ◽  
Total Syntheses ◽  
The Past ◽  
Aspergillus Nomius ◽  
Aflatoxin B

Abstract: Aflatoxins, which are produced by Aspergillus flavus, Aspergillus nomius, and Aspergillus parasiticus, are a group of pentacyclic natural products with difuran and coumarin skeletons. They mainly include aflatoxin B1, B2, G1, G2, M1, and M2. Biologically, aflatoxins are of concern to human health as they can be present as contaminants in food products. The unique skeletons of aflatoxins and their risk to human health have led to the publication of nine remarkable total syntheses (including three asymmetric syntheses) and ten formal total syntheses (including four asymmetric formal syntheses) of aflatoxins in the past 55 years. To better understand the mechanism of the biological activity of aflatoxins and their presence in samples from the food industry, this review summarizes progress in the total synthesis of aflatoxins.

Studies Towards the Synthesis of (+)- and (–)-Anisomycin and Their Analogues

Synthesis ◽  
2017 ◽  
Vol 50 (01) ◽  
pp. 17-34 ◽  
Author(s):  
Arun Shaw ◽  
Sama Ajay
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Present Review ◽  
Formal Synthesis ◽  
Total Syntheses ◽  
Synthetic Approaches

Anisomycin shows potent biological activity and it has attracted much attention since its isolation in 1954, with around 13 total syntheses and 20 formal syntheses, and also two reports concerning analogues of anisomycin, reported to date. The present review highlights all of these synthetic approaches (around 35) to the total or formal synthesis of anisomycin along with its isomers and analogues.1 Introduction2 Isolation and Therapeutic Importance3 Total Synthesis of (+)-, (–)-, and (±)-Anisomycins and Their Analogues4 Formal Synthesis of (+)- and (–)-Anisomycins and Their Analogues5 Conclusion

scholarly journals Phytochemicals from bryophytes: Structures and biological activity

2021 ◽  
pp. 100-100
Author(s):  
Miroslav Novakovic ◽  
Agnieszka Ludwiczuk ◽  
Danka Bukvicki ◽  
Yoshinori Asakawa
Keyword(s):  
Fatty Acids ◽  
Biological Activity ◽  
Vascular Plants ◽  
Unsaturated Fatty Acids ◽  
Biological Activities ◽  
Vitamin B1 ◽  
The Other ◽  
Human Diet ◽  
Highly Unsaturated Fatty Acids ◽  
The World

Little attention has been paid to the bryophytes as sources for human diet despite of the presence of 23000 species in the world. Some mosses contain vitamin B1, tocopherols, prostaglandin-like highly unsaturated fatty acids and phenolic compounds. On the other hand, liverworts contain enantiomeric mono-, sesqui- and diterpenoids to those found in vascular plants. Additionally, they possess bibenzyls, bis-bibenzyls and polyketides, many of them showing various bioactivity such as antimicrobial, antiviral, anti-inflammatory, cytotoxicity against cancer cell lines, muscle relaxing, antioxidant and other. In this paper, the structures of phytochemicals from bryophytes and their biological activities will be discussed.

scholarly journals Recent advances in the total synthesis of agelastatins

2010 ◽  
Vol 82 (12) ◽  
pp. 2231-2246 ◽  
Author(s):  
Guangbin Dong
Keyword(s):  
Biological Activity ◽  
Total Synthesis ◽  
Chemical Structure ◽  
Marine Alkaloids ◽  
Compact Structure ◽  
Total Syntheses ◽  
Strategic Design ◽  
Agelastatin A ◽  
Synthetic Routes ◽  
Insight Into

Agelastatins represent an important family of marine alkaloids in terms of both exceptional biological activity and intriguing chemical structure. In this article, the isolation and biological activity of agelastatins are reviewed, and proposed biosynthetic pathways are summarized. The main focus is given to comparative evaluation of recent total syntheses, mainly of agelastatin A. To date, this has been accomplished by 11 research groups. Their synthetic routes are analyzed and summarized, with a view to furnishing the reader with insight into different strategic design approaches to assembly of a densely functionalized and compact structure.

scholarly journals New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity

Marine Drugs ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 35
Author(s):  
Mohamed Shaaban ◽  
Ghada S. E. Abou-El-Wafa ◽  
Christopher Golz ◽  
Hartmut Laatsch
Keyword(s):  
Biological Activity ◽  
Crude Extract ◽  
Structure Elucidation ◽  
Antimicrobial Activities ◽  
Red Alga ◽  
Spectroscopic Methods ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemical Structures ◽  
Terpene Derivatives

Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.

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