The Relationship Between Gamma-Glutamyl Transferase Levels and Coronary Plaque Burdens and Plaque Structures in Young Adults With Coronary Atherosclerosis

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

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127: Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis

Journal of Clinical Lipidology ◽

10.1016/j.jacl.2008.08.130 ◽

2008 ◽

Vol 2 (5) ◽

pp. S58-S59

Keyword(s):

Metabolic Syndrome ◽

Alanine Aminotransferase ◽

Coronary Atherosclerosis ◽

Gamma Glutamyl Transferase ◽

Gamma Glutamyl ◽

The Metabolic Syndrome ◽

Glutamyl Transferase

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The relationship between gamma glutamyl transferase and survival in patients undergoing potentially curative resection for colorectal cancer

European Journal of Surgical Oncology ◽

10.1016/j.ejso.2008.06.051 ◽

2008 ◽

Vol 34 (10) ◽

pp. 1165

Author(s):

Campbell S.D. Roxburgh ◽

J. Anderson ◽

P. Horgan ◽

D. McMillan

Keyword(s):

Colorectal Cancer ◽

Curative Resection ◽

Gamma Glutamyl Transferase ◽

Gamma Glutamyl ◽

Glutamyl Transferase ◽

The Relationship

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ASSOCIATION BETWEEN GAMMA GLUTAMYL TRANSFERASE AND METABOLIC SYNDROME IN YOUNG ADULTS IN EASTERN INDIA: AN OBSERVATIONAL STUDY

Journal of Drug Delivery and Therapeutics ◽

10.22270/jddt.v4i1.753 ◽

2014 ◽

Vol 4 (1) ◽

Author(s):

Subhasish Dan ◽

Papia Aditya ◽

Prithwijit Banerjee ◽

Musfikur Rahaman ◽

Himansu Roy ◽

...

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Observational Study ◽

Gamma Glutamyl Transferase ◽

Eastern India ◽

Gamma Glutamyl ◽

Glutamyl Transferase

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Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.630409 ◽

2021 ◽

Vol 13 ◽

Author(s):

Zhaoyang Tang ◽

Xueyu Chen ◽

Wenran Zhang ◽

Xiangfu Sun ◽

Qingzhi Hou ◽

...

Keyword(s):

Uric Acid ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Cognitive Function ◽

Chinese Women ◽

Gamma Glutamyl Transferase ◽

Gamma Glutamyl ◽

Increased Risk ◽

Glutamyl Transferase ◽

The Relationship

Background: Dementia, as a global public health problem, is becoming increasingly serious. As a precursor of dementia, mild cognitive impairment (MCI) plays an important role in the diagnosis and prevention of dementia. Recent studies have found a correlation between gamma-glutamyl transferase (GGT) levels and cognitive function in men. The relationship between GGT levels and cognitive function in women remains unclear because GGT activity and expression differ between the sexes.Method: We recruited a total of 2,943 Chinese women from Jidong and Taian in 2019. We grouped the participants according to GGT levels, diagnosed MCI using the Montreal Cognitive Assessment (MOCA) scale, and modeled the study outcomes using logistic regression to explore the relationship between GGT level and MCI. We also analyzed the interaction of obesity, sleep duration, and hyperuricemia with GGT in the development of MCI.Results: The prevalence of MCI increased with increasing GGT level, from the lowest quartile to the highest quartile of GGT: 8.4% (66/786), 14.2% (119/840), 17.6% (108/613), and 21.4% (151/704), respectively. At the same time, as GGT levels increased, so did the risk of MCI. In the fully adjusted model, compared with those for participants in the lowest GGT quartiles, the odds ratios (ORs), and 95% confidence intervals (CIs) for MCI for participants in the second, third, and fourth GGT quartiles were 1.49 (1.04–2.12), 1.53(1.06–2.21), and 1.88 (1.33–2.65), respectively. The risk of developing MCI was further increased in people with high GGT levels who were obese (OR = 1.96, 95% CI: 1.39–2.76, P < 0.001), slept less (OR = 1.91, 95% CI: 1.35–2.71, P < 0.001), had high levels of uric acid (OR = 1.55, 95% CI: 1.03–2.32, P < 0.001), or after menopause (OR = 2.92, 95% CI: 2.07–4.12, P < 0.001).Conclusion: We found that MCI is more common in women with elevated GGT levels, so GGT could be a potential diagnostic marker for MCI. Meanwhile, our findings indicated that women with high GGT levels had an increased risk of MCI when they were obese, sleep deprived, had high serum uric acid (SUA) levels or underwent menopause.

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SERUM LEVELS OF GAMMA-GLUTAMYL TRANSFERASE PREDICT CORONARY ATHEROSCLEROSIS PROGRESSION IN PATIENTS WITH ISCHEMIC HEART DISEASE UNDER OPTIMAL MEDICAL THERAPY

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(11)61096-6 ◽

2011 ◽

Vol 57 (14) ◽

pp. E1096

Author(s):

Luigi M. Biasucci ◽

Roberta Della Bona ◽

Nicola Cosentino ◽

Gianpaolo Niccoli ◽

Silvia Minelli ◽

...

Keyword(s):

Heart Disease ◽

Ischemic Heart Disease ◽

Medical Therapy ◽

Coronary Atherosclerosis ◽

Serum Levels ◽

Ischemic Heart ◽

Gamma Glutamyl Transferase ◽

Gamma Glutamyl ◽

Atherosclerosis Progression ◽

Glutamyl Transferase

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Donor Gamma-Glutamyl Transferase Is Associated With Liver Allograft Discard and Failure

Progress in Transplantation ◽

10.1177/15269248211002800 ◽

2021 ◽

pp. 152692482110028

Author(s):

Theodore Zhang ◽

Brian Hickner ◽

Ronald Cotton ◽

Nhu Thao Nguyen Galvan ◽

John M Vierling ◽

...

Keyword(s):

Graft Failure ◽

Protective Factor ◽

Research Question ◽

Gamma Glutamyl Transferase ◽

Donor Liver ◽

Liver Allograft ◽

Gamma Glutamyl ◽

Glutamyl Transferase ◽

Number Of Individuals ◽

The Relationship

Introduction: The disparity between the number of individuals on the wait list and available liver allografts creates the need for a system that maximizes donor liver utilization and predicts graft failure. Research Question: This study aimed to determine the relationship between donor Gamma-Glutamyl Transferase (GGT), liver discard, and graft failure. Design: Through multivariate analysis from 53 966 deceased liver donors, we adjusted for donor clinical and demographic characteristics and compared donor GGT with allograft discard. We compared donor GGT ranges with graft failure and analyzed data from 47 269 liver recipients. Results: After adjusting for other factors, donor GGT was significantly associated with liver discard, with GGT over 200 U/L being most significant (OR 2.74, CI 2.51-2.99). Donor GGT under 20 U/L was also found to be a protective factor for post-transplant graft failure (HR 0.91, CI 0.83 – 1.00). Conclusion: Going forward, GGT should be included among other characteristics associated with allograft discard considered during the procurement process.

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