The relationship between gamma glutamyl transferase and survival in patients undergoing potentially curative resection for colorectal cancer

2008 ◽  
Vol 34 (10) ◽  
pp. 1165
Author(s):  
Campbell S.D. Roxburgh ◽  
J. Anderson ◽  
P. Horgan ◽  
D. McMillan
Keyword(s):  
Colorectal Cancer ◽  
Curative Resection ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
The Relationship

The Relationship Between the Development of Alcoholic Liver and Pancreatic Diseases and the Induction of Gamma Glutamyl Transferase

1993 ◽  
Vol 28 (Supplement_1B) ◽  
pp. 27-33 ◽  
Author(s):  
Yoshiro Matsuda ◽  
Mutsumi Tsuchishima ◽  
Yasuhiro Ueshima ◽  
Shujiro Takase ◽  
Akira Takada
Keyword(s):  
Gamma Glutamyl Transferase ◽  
Pancreatic Diseases ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
The Relationship

scholarly journals Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Nurbanu Gurbuzer ◽  
Eren Gozke ◽  
Zeliha Ayhan Basturk
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Cerebrovascular Risk ◽  
The Mean ◽  
And Gender ◽  
Glutamyl Transferase ◽  
Relationship Of ◽  
The Relationship

Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (P<0.05). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (P<0.05). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.

scholarly journals Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

2021 ◽  
Vol 13 ◽  
Author(s):  
Zhaoyang Tang ◽  
Xueyu Chen ◽  
Wenran Zhang ◽  
Xiangfu Sun ◽  
Qingzhi Hou ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Chinese Women ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Increased Risk ◽  
Glutamyl Transferase ◽  
The Relationship

Background: Dementia, as a global public health problem, is becoming increasingly serious. As a precursor of dementia, mild cognitive impairment (MCI) plays an important role in the diagnosis and prevention of dementia. Recent studies have found a correlation between gamma-glutamyl transferase (GGT) levels and cognitive function in men. The relationship between GGT levels and cognitive function in women remains unclear because GGT activity and expression differ between the sexes.Method: We recruited a total of 2,943 Chinese women from Jidong and Taian in 2019. We grouped the participants according to GGT levels, diagnosed MCI using the Montreal Cognitive Assessment (MOCA) scale, and modeled the study outcomes using logistic regression to explore the relationship between GGT level and MCI. We also analyzed the interaction of obesity, sleep duration, and hyperuricemia with GGT in the development of MCI.Results: The prevalence of MCI increased with increasing GGT level, from the lowest quartile to the highest quartile of GGT: 8.4% (66/786), 14.2% (119/840), 17.6% (108/613), and 21.4% (151/704), respectively. At the same time, as GGT levels increased, so did the risk of MCI. In the fully adjusted model, compared with those for participants in the lowest GGT quartiles, the odds ratios (ORs), and 95% confidence intervals (CIs) for MCI for participants in the second, third, and fourth GGT quartiles were 1.49 (1.04–2.12), 1.53(1.06–2.21), and 1.88 (1.33–2.65), respectively. The risk of developing MCI was further increased in people with high GGT levels who were obese (OR = 1.96, 95% CI: 1.39–2.76, P &lt; 0.001), slept less (OR = 1.91, 95% CI: 1.35–2.71, P &lt; 0.001), had high levels of uric acid (OR = 1.55, 95% CI: 1.03–2.32, P &lt; 0.001), or after menopause (OR = 2.92, 95% CI: 2.07–4.12, P &lt; 0.001).Conclusion: We found that MCI is more common in women with elevated GGT levels, so GGT could be a potential diagnostic marker for MCI. Meanwhile, our findings indicated that women with high GGT levels had an increased risk of MCI when they were obese, sleep deprived, had high serum uric acid (SUA) levels or underwent menopause.

scholarly journals Serum Gamma Glutamyl transferase is a predictor of recurrence after R0 hepatectomy for patients with colorectal cancer liver metastases

2020 ◽  
Vol 12 ◽  
pp. 175883592094797
Author(s):  
Binyi Xiao ◽  
Jianhong Peng ◽  
Jinghua Tang ◽  
Yuxiang Deng ◽  
Yujie Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factor ◽  
Neoadjuvant Chemotherapy ◽  
Liver Metastases ◽  
Liver Surgery ◽  
R0 Resection ◽  
Gamma Glutamyl Transferase ◽  
Colorectal Cancer Liver Metastases ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

Objectives: Gamma glutamyl-transpeptidase (GGT) has been shown as a prognostic marker in many cancers. The aim of this study was to explore whether serum GGT could predict tumor recurrence in patients with liver-confined colorectal cancer liver metastases (CRCLM) undergoing R0 resection. Methods: We reviewed patients who had underwent liver surgery for CRCLM. Patients with liver-only metastases that underwent R0 resection were included. Pre-operative serum GGT were classified into either high or low using a cut-off value of 33 U/L for female and 51 U/L for male. Relapse-free survival (RFS) was compared in relation to GGT and other clinicopathological factors. Results: Of the 350 patients included, 108 (30.9%) had a high serum GGT. Patients with metachronous liver metastases, number of metastases ⩾2, size of the largest metastasis ⩾3 cm, or a history of neoadjuvant chemotherapy had a higher GGT level ( p = 0.001, 0.027, 0.001, and 0.002, respectively). In survival analyses, patients with a high GGT had a shorter RFS than those with a low GGT, with a median RFS of 11.8 versus 30.3 months ( p < 0.001). RFS was also associated with the number of metastases, size of the largest metastasis and the delivery of neoadjuvant chemotherapy. In multivariate analysis, GGT remained an independent prognostic factor of RFS. Conclusions: Our study demonstrates that the serum GGT level before liver surgery is an adverse prognostic factor of RFS for patients with liver-confined CRCLM.

Donor Gamma-Glutamyl Transferase Is Associated With Liver Allograft Discard and Failure

2021 ◽  
pp. 152692482110028
Author(s):  
Theodore Zhang ◽  
Brian Hickner ◽  
Ronald Cotton ◽  
Nhu Thao Nguyen Galvan ◽  
John M Vierling ◽  
...  
Keyword(s):  
Graft Failure ◽  
Protective Factor ◽  
Research Question ◽  
Gamma Glutamyl Transferase ◽  
Donor Liver ◽  
Liver Allograft ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase ◽  
Number Of Individuals ◽  
The Relationship

Introduction: The disparity between the number of individuals on the wait list and available liver allografts creates the need for a system that maximizes donor liver utilization and predicts graft failure. Research Question: This study aimed to determine the relationship between donor Gamma-Glutamyl Transferase (GGT), liver discard, and graft failure. Design: Through multivariate analysis from 53 966 deceased liver donors, we adjusted for donor clinical and demographic characteristics and compared donor GGT with allograft discard. We compared donor GGT ranges with graft failure and analyzed data from 47 269 liver recipients. Results: After adjusting for other factors, donor GGT was significantly associated with liver discard, with GGT over 200 U/L being most significant (OR 2.74, CI 2.51-2.99). Donor GGT under 20 U/L was also found to be a protective factor for post-transplant graft failure (HR 0.91, CI 0.83 – 1.00). Conclusion: Going forward, GGT should be included among other characteristics associated with allograft discard considered during the procurement process.

Prognostic value of gamma-glutamyl transferase in patients with diabetes mellitus and coronary artery disease

2016 ◽  
Vol 49 (15) ◽  
pp. 1127-1132 ◽  
Author(s):  
Gjin Ndrepepa ◽  
Roisin Colleran ◽  
Anke Luttert ◽  
Siegmund Braun ◽  
Salvatore Cassese ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Value ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Patients With Diabetes ◽  
Artery Disease ◽  
Glutamyl Transferase

Bước đầu khảo sát sự ổn định của một số chỉ số xét nghiệm sinh hóa trong máu toàn phần và huyết tương theo thời gian bảo quản mẫu bệnh phẩm

2021 ◽  
Vol 16 (3) ◽  
Author(s):  
Đinh Thị Thảo ◽  
Trần Thái Hà ◽  
Nguyễn Viết Tân ◽  
Vi Thị Nhung ◽  
Nguyễn Cẩm Thạch
Keyword(s):  
Aspartate Aminotransferase ◽  
Alanine Aminotransferase ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Mau Mau ◽  
Glutamyl Transferase

Mục tiêu: Đánh giá ảnh hưởng của thời gian bảo quản đến kết quả phân tích các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), acid uric, bilirubin toàn phần, bilirubin trực tiếp trong mẫu máu toàn phần và huyết tương. Đối tượng và phương pháp: Gồm 162 mẫu máu toàn phần được chống đông bằng Li-heparin của 81 bệnh nhân (mỗi bệnh nhân lấy 2 ống mẫu) đến khám tại Khoa Khám bệnh - Bệnh viện Trung ương Quân đội 108 từ ngày 15/01/2021 đến ngày 15/02/2021. Với mỗi bệnh nhân: Ngay sau khi lấy máu, ống mẫu 1 được ly tâm, phân tích thường quy các chỉ số hóa sinh (phần còn lại sau phân tích gọi là mẫu 1), ống mẫu 2 được tách lấy huyết tương (mẫu 2). Sau đó, cả 2 mẫu được lưu trong tủ lạnh ở nhiệt độ 4oC. Sử dụng các mẫu này để phân tích các chỉ số hóa sinh tại các thời điểm 24, 48, và 72 giờ sau khi lấy máu. Kết quả: Nồng độ AST của các mẫu 1 được lưu trong 24, 48, 72 giờ cao hơn nồng độ AST phân tích thường quy (p<0,05). Nồng độ bilirubin toàn phần, bilirubin trực tiếp của mẫu 1 và mẫu 2 giảm dần theo thời gian lưu mẫu (p<0,05). Kết luận: Nồng độ các chỉ số AST, bilirubin toàn phần, bilirubin trực tiếp của các mẫu lưu (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) không ổn định theo thời gian bảo quản ở 4oC. Nồng độ các chỉ số urea, creatinine, triglycerid, cholesterol, HDL-cholesterol, LDL-cholesterol, ALT, GGT, acid uric (huyết tương và mẫu máu sau phân tích không loại bỏ các thành phần hữu hình) ổn định đến 72 giờ ở 4oC. Từ khóa: Hóa sinh, bảo quản bệnh phẩm, Bệnh viện Trung ương Quân đội 108.

Sign in / Sign up

Export Citation Format

Share Document