Dual Loading of Doxorubicin and Magnetic Iron Oxide into PLA‐TPGS Nanoparticles: Design, in vitro Drug Release Kinetics, and Biological Effects on Cancer Cells

This work presents the development of multifunctional therapeutic membranes based on a high-performance block copolymer scaffold formed by polyether (PE) and polyamide (PA) units (known as PEBA) and layered double hydroxide (LDH) biomaterials, with the aim to study their uses as wound dressings. Two LDH layer compositions were employed containing Mg2+ or Zn2+, Fe3+ and Al3+ cations, intercalated with chloride anions, abbreviated as Mg-Cl or Zn-Cl, or intercalated with naproxenate (NAP) anions, abbreviated as Mg-NAP or Zn-NAP. Membranes were structurally and physically characterized, and the in vitro drug release kinetics and cytotoxicity assessed. PEBA-loading NaNAP salt particles were also prepared for comparison. Intercalated NAP anions improved LDH–polymer interaction, resulting in membranes with greater mechanical performance compared to the polymer only or to the membranes containing the Cl-LDHs. Drug release (in saline solution) was sustained for at least 8 h for all samples and release kinetics could be modulated: a slower, an intermediate and a faster NAP release were observed from membranes containing Zn-NAP, NaNAP and Mg-NAP particles, respectively. In general, cell viability was higher in the presence of Mg-LDH and the membranes presented improved performance in comparison with the powdered samples. PEBA containing Mg-NAP sample stood out among all membranes in all the evaluated aspects, thus being considered a great candidate for application as multifunctional therapeutic dressings.

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Formulation and Evaluation of Transdermal patch of Methimazole

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00811 ◽

2021 ◽

pp. 4667-4672

Author(s):

Nani Tadhi ◽

Himansu Chopra ◽

Gyanendra Kumar Sharma

Keyword(s):

Drug Release ◽

Release Kinetics ◽

In Vitro Release ◽

Transdermal Patch ◽

Formulation Development ◽

In Vitro Drug Release ◽

Drug Release Study ◽

Percent Moisture ◽

Release Study

Transdermal patch is a drug delivery device in which the drugs are incorporated and is design in such a way that it releases the drug in sustained and at predetermined rate to deliver the drug through the skin to the systemic circulation painlessly. The aim of this research study was to formulate a controlled and sustained release transdermal matrix type patch of Methimazole. The matrix patch was prepared by solvent casting method using a various polymer in different concentration, HPMC (hydrophilic), Eudragit RL100 and Ethyl cellulose (hydrophobic) polymer. Total 9 prototype formulation were prepared and it was subjected for various evaluation test; weight uniformity, Folding endurance, thickness, Drug content, percent moisture content, percent Moisture uptake and In-vitro drug release study using Franz diffusion cell. The in-vitro CDR% data was fit into kinetics model to see the release kinetics from the patches. The Formulation F5 was choosen as a best formulation according to in-vitro drug release study. The in-vitro release was found 81.12 % in 12 hours, it followed zero order kinetics. The nature of polymer and concentration ratio of polymers plays a crucial role for obtaining a good transdermal patch design; therefore optimisation is very important step to formulate a desired TDDS. Therefore the result of the study encourages a further study and is hopeful that the present study would contribute to the recent pharmaceutical research for formulation development.

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Fabrication and Release Kinetics of Liposomes Containing Leuprolide Acetate

Journal of Basic and Applied Research in Biomedicine ◽

10.51152/jbarbiomed.v7i1.213 ◽

2021 ◽

Vol 7 (1) ◽

pp. 35-38

Author(s):

Sudipta Das ◽

Arnab Samanta ◽

Koushik Bankura ◽

Debatri Roy ◽

Amit Nayak

Keyword(s):

Drug Release ◽

Release Kinetics ◽

In Vitro Release ◽

Zero Order ◽

Leuprolide Acetate ◽

Lipid Film ◽

In Vitro Drug Release ◽

Liposomal Formulations ◽

Kinetics Of

The present work is focused on the preparation and in vitro release kinetics of liposomal formulation of Leuprolide Acetate. In this work, “Thin Lipid Film Hydration Method” was used for preparation of Leuprolide Acetate loaded liposomes. Prepared liposomal formulations of Leuprolide acetate was evaluated by drug entrapment study, in-vitro drug release kinetics and stability studies. The percentage drug entrapment of Leuprolide acetate for F1 and F2 formulations were found to be 78.14 ± 0.67 and 66.70 ± 0.81% respectively. In-vitro drug release study of liposomal formulations had shown zero order release pattern. Regression co-efficient (R2) value of Zero order kinetics for F1 and F2 formulations were 0.9912 and 0.9676 respectively. After storing formulations for 1 month, stability testing was done at 40C.It was found that all batches were stable. These liposomal formulations of Leuprolide acetate can be formulated for parenteral application to treat prostate cancer and in women, to treat symptoms of endometriosis (overgrowth of uterine lining outside of the uterus) or uterine fibroids.

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Optimizing the Role of Polymer Blend in the Preparation of Acyclovir Controlled-Release Tablets: An Approach for Better Patient Compliance

10.20944/preprints201807.0165.v1 ◽

2018 ◽

Author(s):

Barkat Khan ◽

Faheem Haider ◽

Kifayat Shah ◽

Bushra Uzair ◽

Kaijian Hou ◽

...

Keyword(s):

Controlled Release ◽

Drug Release ◽

Release Kinetics ◽

Immediate Release ◽

Matrix Tablets ◽

Release Mechanism ◽

In Vitro Drug Release ◽

Solubility Study ◽

Release Data

This study was carried out to formulate and evaluate controlled release (CR) matrix tablets of Acyclovir using combination of hydrophilic and hydrophobic polymers. Acyclovir is a guanine derivative and is its half-life is short hence administered five times a day using immediate release tablets. Six formulations (F1-F6) were developed using Ethocel and Carbopol in equal combinations at drug-polymer (D:P) ratio of 10:5, 10:6, 10:7, 10:8, 10:9 and 10:10. Solubility study was performed using six different solvents. The compatibility studies were carried out using FTIR and DSC. According to USP, Quality Control and dimensional tests (hardness, friability, disintegration and thickness) were executed. In-vitro drug release studies of Acyclovir was carried out in dissolution apparatus using using 0.1 N HCl medium at constant temperature of 37 ± 0.5 ºC. In order to analyze the drug release kinetics, five different mathematical models were applied to the release data. The results showed that there was no incompatibility between drug and polymers. Physical QC tests were found within limits of USP. The release was retarded upto 24 hrs and non-fickian in-vitro drug release mechanism was found. A formulation developed using blend of polymers, showed excellent retention and desired release profiles thus providing absolute control for 24 hrs.

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In vitro bioactivity and drug release kinetics studies of mesoporous silica-biopolymer composites

Journal of Porous Materials ◽

10.1007/s10934-015-0027-5 ◽

2015 ◽

Vol 22 (6) ◽

pp. 1465-1472 ◽

Cited By ~ 5

Author(s):

M. Narasimha Reddy ◽

K. K. Cheralathan ◽

S. Sasikumar

Keyword(s):

Drug Release ◽

Mesoporous Silica ◽

Release Kinetics ◽

In Vitro Bioactivity ◽

Drug Release Kinetics ◽

Kinetics Studies ◽

Biopolymer Composites

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FORMULATION AND EVALUATION OF NATEGLINIDE NANOSPONGES

INDIAN DRUGS ◽

10.53879/id.55.02.10717 ◽

2018 ◽

Vol 55 (02) ◽

pp. 27-35

Author(s):

A. A Bakliwal ◽

◽

D. S. Jat ◽

S. G. Talele ◽

A. G. Jadhav

Keyword(s):

Particle Size ◽

Drug Release ◽

Release Kinetics ◽

Synthesis Method ◽

Ultra Sound ◽

Size Analysis ◽

Release Kinetic ◽

In Vitro Drug Release ◽

Drug Content

The objective of the present study was to produce extended release nateglinide nanosponges for oral delivery. Preparation of nanosponges leads to solubility enhancement. Nateglinide is a BCS Class II drug, having low solubility. So, to increase the solubility of nateglinide it is formulated into nanosponges. Nanosponges using ethyl cellulose as a polymer and dichloromethane as a cross-linker were prepared successfully by ultra-sound assisted synthesis method. The effects of different drug: placebo ratios on the physical characteristics of the nanosponges as well as the drug content and in vitro drug release of the nanosponges were investigated. Particle size analysis and surface morphology of nanosponges were performed. The scanning and transmission electron microscopy of nanosponges showed that they were spongy in nature. The particle size was found to be in the range 46.37 - 97.23 nm out of which particle size of the optimized formulation was 51.79 nm and the drug content was found to 79.43 %. The optimized nanosponge formulations were selected for preparing nanosponge tablets for extended drug delivery by oral route. These tablets were prepared using xanthan gum and PVP K-30 and were evaluated by pre-compression and post-compression parameters. The nateglinide nanosponges tablet formulation were studied for different parameters using Design Expert Software. All formulations were evaluated for in vitro drug release analyzed according to various release kinetic models and it was found that it follows zero order release kinetics.

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