scholarly journals Predicting amyloid status using self‐report information from an online research and recruitment registry: The Brain Health Registry

Author(s):  
Miriam T. Ashford ◽  
John Neuhaus ◽  
Chengshi Jin ◽  
Monica R. Camacho ◽  
Juliet Fockler ◽  
...  
Author(s):  
T. Banh ◽  
C. Jin ◽  
J. Neuhaus ◽  
R.S. Mackin ◽  
P. Maruff ◽  
...  

Introduction: The feasibility and validity of unsupervised, longitudinal brief computerized cognitive batteries is unknown. Methods: Participants aged 56-90 (N = 19476) from the Brain Health Registry (BHR) completed the CogState Brief Battery (CBB) at 6-month intervals over a period of 5 years. We used linear mixed-effects models to assess whether cross-sectional and longitudinal performance on CBB within BHR was associated with demographic and cognitive characteristics. We also defined a group of CBB decliners based on subject-specific slopes and estimated associations between decliner status and participant characteristics. Results: We found weak associations between longitudinal change in CBB and participant characteristics. Cross-sectional CBB scores were significantly associated with participant characteristics such as age, gender, ethnicity, self-reported disease status, and memory concern. CBB decliners were more likely to self-report mild cognitive impairment (MCI) and memory concerns. Discussion: Cross-sectional, remote CBB shows evidence of construct validity, but our results suggest that longitudinal assessment may not provide additional value for identifying those at risk for and with cognitive impairment.


2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Jack Albright ◽  
Miriam T. Ashford ◽  
Chengshi Jin ◽  
John Neuhaus ◽  
Monica R. Camacho ◽  
...  

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Miriam T. Ashford ◽  
John Neuhaus ◽  
Chengshi Jin ◽  
Monica R Camacho ◽  
Juliet Fockler ◽  
...  

2019 ◽  
Vol 68 (3) ◽  
pp. 1029-1038 ◽  
Author(s):  
Brenna Cholerton ◽  
Michael W. Weiner ◽  
Rachel L. Nosheny ◽  
Kathleen L. Poston ◽  
R. Scott Mackin ◽  
...  

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 783-783
Author(s):  
Qu Tian ◽  
Andrea Rosso ◽  
Nancy Glynn ◽  
Xiaonan Zhu ◽  
Caterina Rosano

Abstract The brain demands and consumes more energy than any other organ. Lower perceived energy may indicate compromised brain health. Little empirical data exists on the association between perceived energy and brain structure. Neuroimaging was obtained in 300 participants (mean age=83±3 y/o, 40% blacks, 57%women) with repeated self-reported energy measures(scale0-10) in the past decade. Energy decline was computed as rate of change by linear mixed models(-0.06/year). Associations of energy decline with volumes of cognitive (dorsolateral prefrontal cortex, hippocampus) and motor (precentral gyrus, putamen, caudate) areas were examined using linear regression, adjusted for demographics and total gray matter atrophy. A steeper decline in energy was associated with smaller volumes of right putamen (p=0.013) and caudate (p=0.043), a trend in right precentral gyrus (p=0.085), but not in prefrontal cortex or hippocampus. Declining energy by self-report may indicate atrophy localized in subcortical motor areas. Studies to identify the mechanisms underlying these associations are warranted.


2015 ◽  
Vol 11 (7S_Part_10) ◽  
pp. P478-P479
Author(s):  
Michael W. Weiner ◽  
Rachel L. Nosheny ◽  
Derek Flennkiken ◽  
Philip S. Insel ◽  
Shannon Finley ◽  
...  

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S124-S124
Author(s):  
Holly A Bardutz ◽  
Constance Corley

Abstract Two groups of Canadian women, over the age of 65, were interviewed (n = 20) in a study focused on brain health. The first group (n = 12) regularly attended exercise classes and met the exercise standards of the Canadian Society of Exercise Physiologists for the age group over 65 years for at least six months. Women in the comparison group (n = 8) had been taking adult education classes twice a week or more for at least six months. Thematic coding was used to analyze the results. Both groups reported benefits from their participation in their respective groups. However, the results show that the group who exercised regularly consistently reported improved mood, increased mental alertness, a better ability to handle stress, less pain, and improved sleep. These factors were not reported by the non-exercise group, which did benefit by gaining new knowledge, making new friends and feeling good because they were learning new things. This study suggests that Canadian women over the age of 65 who have been exercising regularly report many of the effects of exercise on the brain that are beneficial to their well-being. They did not specifically mention the new brain cells being made (neurogenesis) nor did they note neuronal rewiring (neuroplasticity), however they did self-report some psychological benefits that the Comparison Group did not report, as noted above. This research has implications for both practice and research.


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