Commentary on the status of short-term tests for chemical carcinogens

1988 ◽  
Vol 11 (4) ◽  
pp. 437-441 ◽  
Author(s):  
M. D. Shelby ◽  
E. Zeiger ◽  
R. W. Tennant
2021 ◽  
pp. 089020702110173
Author(s):  
Nadin Beckmann ◽  
Damian P Birney ◽  
Amirali Minbashian ◽  
Jens F Beckmann

The study aimed to investigate the status of within-person state variability in neuroticism and conscientiousness as individual differences constructs by exploring their (a) temporal stability, (b) cross-context consistency, (c) empirical links to selected antecedents, and (d) empirical links to longer term trait variability. Employing a sample of professionals ( N = 346) from Australian organisations, personality state data together with situation appraisals were collected using experience sampling methodology in field and repeatedly in lab-like settings. Data on personality traits, cognitive ability, and motivational mindsets were collected at baseline and after two years. Contingent (situation contingencies) and non-contingent (relative SD) state variability indices were relatively stable over time and across contexts. Only a small number of predictive effects of state variability were observed, and these differed across contexts. Cognitive ability appeared to be associated with state variability under lab-like conditions. There was limited evidence of links between short-term state and long-term trait variability, except for a small effect for neuroticism. Some evidence of positive manifold was found for non-contingent variability. Systematic efforts are required to further elucidate the complex pattern of results regarding the antecedents, correlates and outcomes of individual differences in state variability.


1997 ◽  
Vol 66 (2-3) ◽  
pp. 273-300 ◽  
Author(s):  

AbstractThis article aims to throw a light on the problems relating to the proposed enlargement of the composition of the UN Security Council at present by studying the creation of four non-permanent seats in the Security Council in 1963 from the British and the French perspectives. The examination is based on the author's research of original documents in the archives of the British and French foreign ministries and upon information provided to the author by British, French and Finnish diplomats. The author concludes that, as between 1946 and 1963, British and French short term interests are still best served by maintaining the status quo in the Security Council. However, in a long term perspective it is not clear where the interests of these two States lie.


PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0247272
Author(s):  
Claudius Gros ◽  
Roser Valenti ◽  
Lukas Schneider ◽  
Benedikt Gutsche ◽  
Dimitrije Marković

The distinct ways the COVID-19 pandemic has been unfolding in different countries and regions suggest that local societal and governmental structures play an important role not only for the baseline infection rate, but also for short and long-term reactions to the outbreak. We propose to investigate the question of how societies as a whole, and governments in particular, modulate the dynamics of a novel epidemic using a generalization of the SIR model, the reactive SIR (short-term and long-term reaction) model. We posit that containment measures are equivalent to a feedback between the status of the outbreak and the reproduction factor. Short-term reaction to an outbreak corresponds in this framework to the reaction of governments and individuals to daily cases and fatalities. The reaction to the cumulative number of cases or deaths, and not to daily numbers, is captured in contrast by long-term reaction. We present the exact phase space solution of the controlled SIR model and use it to quantify containment policies for a large number of countries in terms of short and long-term control parameters. We find increased contributions of long-term control for countries and regions in which the outbreak was suppressed substantially together with a strong correlation between the strength of societal and governmental policies and the time needed to contain COVID-19 outbreaks. Furthermore, for numerous countries and regions we identified a predictive relation between the number of fatalities within a fixed period before and after the peak of daily fatality counts, which allows to gauge the cumulative medical load of COVID-19 outbreaks that should be expected after the peak. These results suggest that the proposed model is applicable not only for understanding the outbreak dynamics, but also for predicting future cases and fatalities once the effectiveness of outbreak suppression policies is established with sufficient certainty. Finally, we provide a web app (https://itp.uni-frankfurt.de/covid-19/) with tools for visualising the phase space representation of real-world COVID-19 data and for exporting the preprocessed data for further analysis.


2014 ◽  
Vol 54 (3) ◽  
pp. 300-305
Author(s):  
Zbigniew Pawlonka ◽  
Katarzyna Rymuza ◽  
Krzysztof Starczewski ◽  
Antoni Bombik

Abstract The purpose of the study was to determine the relationship between herbicide rate and weed community biodiversity in continuous wheat. A six-year field experiment was conducted to examine the effect of four chlorsulfuron rates in comparison with untreated (the control) plots, on the status and severity of weed infestation - in successive study years of cultivating winter wheat in monoculture. In addition, the following indices were calculated: Shannon-Wiener and Simpson’s index of biodiversity, and Simpson’s index of domination. A total of 36 weedy species were identified in the experimental plots. The richest segetal communities were established in the control plots. An application of herbicide reduced the biodiversity of the agrophytocensosis. A short-term monoculture did not impoverish the species richness of the weed community established in winter wheat. The average number of species in the community was significantly greater in the second study year. In the initial study years of monoculture, the biodiversity of the segetal community increased markedly compared with rotation-based cultivation. The calculated indices of biodiversity were not significantly affected by herbicide rate or monoculture but the indices confirmed the trends outlined by an analysis of the status and level of weed infestation.


Author(s):  
H. Bartsch ◽  
C. Malaveille ◽  
A.-M. Camus ◽  
G. Brun ◽  
A. Hautefeuille

2019 ◽  
pp. 138-180
Author(s):  
Douglas Allen

Ever since 9/11 in the US and 26/11 in India, terrorism has been a central concern. Gandhi is generally assumed to be of little value when confronting terrorism today. At best, he is irrelevant; at worst, he is complicit and contributes to the crisis since he opposes necessary violent responses. This essay argues that while Gandhi does not have all of the answers for dealing with terrorism today, he provides us with a complex analysis essential for understanding and responding to the multidimensional structural crisis. After analyzing the nature and meaning of terrorism, we focus on the following topics: Gandhi’s interactions with terrorists; his means-ends analysis and his short-term and long-term preventative approaches to terrorism; his analysis of absolute truth and relative truth in approaching terrorism; and his general analysis of the status of “the other” in transforming our relations with violent, terrorizing, and terrorized others.


2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Dana P. Goldman ◽  
Darius N. Lakdawalla ◽  
James R. Baumgardner ◽  
Mark T. Linthicum

AbstractMedical innovation has generated significant gains in health over the past decades, but these advances have been accompanied by rapid growth in healthcare spending. Faced with a growing number of high-cost but high-impact innovations, some have argued to constrain prices for new therapies – especially through global caps on pharmaceutical spending and limits on prices for individual drugs. We show that applying this threshold to past innovations would have limited access to many highly valuable drugs such as statins and anti-retrovirals. We also argue that budget caps violate several important principles of health policy. First, budget caps treat healthcare spending as a consumption good, like going to a movie or buying a meal. However, healthcare spending should be viewed as an investment, whose benefits accrue over many years – much like spending on education. Second, budgetary cost is a poor indicator of value, thereby distorting coverage decisions. Third, affordability arguments often use a short-term horizon, thereby missing that long-term health is society’s ultimate goal. Fourth, assessments of benefit should incorporate not just the immediate clinical benefit to patients, but also long-term health improvements, cost savings, and increased productivity. Fifth, global budget caps arbitrarily anchor spending on the status quo, thereby setting too stringent a threshold for socially-desirable innovation. In sum, a solitary focus on short-term costs can be detrimental to population health in the long-run. When medical treatment decisions are properly viewed as investments, budget caps are not the answer; rather, we need to find mechanisms to encourage spending decisions based on long-term value. Only then can we generate health returns to societal investments, while also encouraging the new research and development necessary to extend the gains of recent decades.


2011 ◽  
Vol 201-203 ◽  
pp. 2634-2644 ◽  
Author(s):  
He Cen Wang ◽  
De Hou Jiang ◽  
Qin Wang

To meet the standard requirements of dust emission for boiler and ensure the safety and normal operation of desulfurization equipment, bag dust filtering technologies have been used widely to deal with flue gas. Because of design defects and different running conditions, abnormal breakage may appear in the key parts of the bags, particularly some issues such as oxidation and acidic corrosion of the bags may happen in short-term application of electrostatic-bag precipitators. This paper elaborates the status of bag filters in coal-fired power plants, discusses some issues of bag filtering technology in design, manufacture and operation, and especially analyses the special problems of composite electrostatic-bag precipitators. Solutions are presented for extending the life of filtering bags.


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