Integrative Research in Biology (NSF)

2021 ◽  
Vol 45 (21) ◽  
pp. 3-3
Keyword(s):  
Integrative Research

436 Obstructive Sleep Apnea Treatment (e.g., CPAP) Differential Effects on Cognitive Performance

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A172-A173
Author(s):  
Ei Hlaing ◽  
Stephanie Clancy Dollinger ◽  
Terry Brown
Keyword(s):  
Sleep Quality ◽  
Cognitive Deficits ◽  
Daytime Sleepiness ◽  
Short Term Memory ◽  
Cognitive Tests ◽  
Subjective Sleep Quality ◽  
Cognitive Improvement ◽  
Cpap Treatment ◽  
Integrative Research ◽  
Obstructive Sleep

Abstract Introduction The efficacy of CPAP treatment for cognitive improvement among patients with OSA is inconsistent. Naegele et al. (1995) found that short term memory impairment persisted even after 4 to 6 months of CPAP; O’Donoghue et al. (2012) have reported they did not find improvement in vigilance or memory; Felver-Grant (2007) found that working memory improved but not other cognitive tests. Kanbay et al. (2015) found patients improved on the MMSE scores after 3 months of CPAP treatment. Kim et al. (2018) claimed just 3 weeks of CPAP treatment improved attention, sleep quality, and excessive daytime sleepiness (EDS). CPAP therapy has little effect on the improvement of cognitive deficits associated with OSA if the patients did not complain of daytime sleepiness (Zhou et al,, 2016). Methods Both untreated OSA patients (N=19) and ApneaLinkTM- screened controls (N=16) were administered a battery of cognitive tests before the patients started using CPAP and these two conditions were tested again after 3 months of CPAP treatment. A Fisher’s Exact Chi-Square test was used to determine if there was an association between conditions (OSA patients vs. Controls) and level of performance on cognitive tests (low vs. high scores) at the baseline and after 3 months of treatment. Results Depression scores, subjective sleep quality scores (global PSQI), EDS scores (Epworth Sleepiness Scale), and mood disturbance (Profile of Mood States) decreased after 3 months of CPAP treatment just for patients. Controls (individuals without moderate or severe OSA) performed better at the second time on phonemic fluency, immediate recall memory test, and 30 minute delayed memory recall test. Conclusion The fact that patients did not do better at time 2 on any of the cognitive tests may indicate a long term effect of hypoxia on the brain. The cognitive deficits may not reverse within the first 3 months of CPAP although self-reported depressive symptoms and perception of sleep quality and positive mood have improved when patients reported they are compliant with the treatment. Support (if any) A grant from the Center for Integrative Research on Cognitive Neural Science, Southern Illinois University Carbondale was received.

Responsible innovation and social innovation: toward an integrative research framework

2019 ◽  
Vol 46 (6) ◽  
pp. 742-755 ◽  
Author(s):  
Karsten Bolz ◽  
Anne de Bruin
Keyword(s):  
Social Innovation ◽  
Field Research ◽  
Responsible Innovation ◽  
Systematic Research ◽  
Content Type ◽  
Policy Practice ◽  
Integrative Framework ◽  
Integrative Research ◽  
Conceptual Paper ◽  
Innovation Study

PurposeResponsible innovation (RI) and social innovation (SI) are two fields of innovation study experiencing burgeoning policy, practice and research interest. Despite this rapid rise in popularity, the scholarly literature in these two related areas of innovation study remains quite separate, stymieing the growth of shared research insights. The purpose of this paper is to propose a pragmatic, process-based framework that lends itself to advancing systematic research in both fields while retaining their distinct identities.Design/methodology/approachThis conceptual paper outlines an analogy-inspired framework that builds on the logical thinking put forward by Philosopher Willard Van Orman Quine in 1962. It focusses on key processes that cross-cut both fields.FindingsReflexivity, collaboration and design are identified as three broad core processes that span both the RI and SI fields and form the basis of an integrative framework that highlights the scope for cross-field research pollination.Originality/valueThe literature that draws these two fields together is virtually non-existent. The paper uses analogy to facilitate awareness of the parallels between these two areas of innovation study. The integrative framework put forward in the paper is of value for advancing cumulative research in innovation fields of critical importance to the society.

Qui non proficit, deficit: Experimental models for ‘integrative’ research of affective disorders

2010 ◽  
Vol 121 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Justin L. LaPorte ◽  
Rupert J. Egan ◽  
Peter C. Hart ◽  
Carisa L. Bergner ◽  
Jonathan M. Cachat ◽  
...  
Keyword(s):  
Affective Disorders ◽  
Experimental Models ◽  
Integrative Research

scholarly journals Differential Regulatory Analysis Based on Coexpression Network in Cancer Research

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Junyi Li ◽  
Yi-Xue Li ◽  
Yuan-Yuan Li
Keyword(s):  
Cancer Research ◽  
Large Scale ◽  
Rapid Development ◽  
Differential Expression Analysis ◽  
Coexpression Network ◽  
Differential Analysis ◽  
Integrative Research ◽  
Research Fields ◽  
System Properties ◽  
Regulatory Analysis

With rapid development of high-throughput techniques and accumulation of big transcriptomic data, plenty of computational methods and algorithms such as differential analysis and network analysis have been proposed to explore genome-wide gene expression characteristics. These efforts are aiming to transform underlying genomic information into valuable knowledges in biological and medical research fields. Recently, tremendous integrative research methods are dedicated to interpret the development and progress of neoplastic diseases, whereas differential regulatory analysis (DRA) based on gene coexpression network (GCN) increasingly plays a robust complement to regular differential expression analysis in revealing regulatory functions of cancer related genes such as evading growth suppressors and resisting cell death. Differential regulatory analysis based on GCN is prospective and shows its essential role in discovering the system properties of carcinogenesis features. Here we briefly review the paradigm of differential regulatory analysis based on GCN. We also focus on the applications of differential regulatory analysis based on GCN in cancer research and point out that DRA is necessary and extraordinary to reveal underlying molecular mechanism in large-scale carcinogenesis studies.

Cultured Monkeys

2008 ◽  
Vol 17 (6) ◽  
pp. 410-414 ◽  
Author(s):  
Michael A. Huffman ◽  
Charmalie A.D. Nahallage ◽  
Jean-Baptiste Leca
Keyword(s):  
Comparative Study ◽  
Systematic Study ◽  
Japanese Macaques ◽  
Mediated Learning ◽  
Research Paradigm ◽  
Animal Kingdom ◽  
Integrative Research ◽  
Group Members ◽  
Term Maintenance

Sixty years ago, the notion that animals could have culture was unthinkable to most behavioral scientists. Today, evidence for innovation, transmission, acquisition, long-term maintenance, and intergroup variation of behavior exists throughout the animal kingdom. What can the longitudinal and comparative study of monkeys handling stones tell us about how culture evolved in humans? Now in its 30th year, the systematic study of stone-handling behavior in multiple troops of Japanese macaques has shown that socially mediated learning is essential to explain the spread, persistence, and transformation of individual behavioral innovations among group members. The integrative research paradigm presented here can be applied to the study of various candidate behavioral traditions in other species.

scholarly journals Datanator: an integrated database of molecular data for quantitatively modeling cellular behavior

2020 ◽  
Author(s):  
Yosef D. Roth ◽  
Zhouyang Lian ◽  
Saahith Pochiraju ◽  
Bilal Shaikh ◽  
Jonathan R. Karr
Keyword(s):  
Additional Data ◽  
Molecular Data ◽  
Rna Modifications ◽  
Cellular Behavior ◽  
Reaction Rate Constants ◽  
Integrative Research ◽  
Wide Range ◽  
Community Initiative ◽  
Biochemical Research ◽  
Diverse Data

AbstractIntegrative research about multiple biochemical subsystems has significant potential to help advance biology, bioengineering, and medicine. However, it is difficult to obtain the diverse data needed for integrative research. To facilitate biochemical research, we developed Datanator (https://datanator.info), an integrated database and set of tools for finding clouds of multiple types of molecular data about specific molecules and reactions in specific organisms and environments, as well as data about chemically-similar molecules and reactions in phylogenetically-similar organisms in similar environments. Currently, Datanator includes metabolite concentrations, RNA modifications and half-lives, protein abundances and modifications, and reaction rate constants about a broad range of organisms. Going forward, we aim to launch a community initiative to curate additional data. Datanator also provides tools for filtering, visualizing, and exporting these data clouds. We believe that Datanator can facilitate a wide range of research from integrative mechanistic models, such as whole-cell models, to comparative data-driven analyses of multiple organisms.

scholarly journals A Critical Review of the Use of Wenger's Community of Practice (CoP) Theoretical Framework in Online and Blended Learning Research, 2000-2014

2017 ◽  
Vol 21 (1) ◽  
Author(s):  
Sedef Uzuner Smith ◽  
Suzanne Hayes ◽  
Peter Shea
Keyword(s):  
Communities Of Practice ◽  
Blended Learning ◽  
Community Of Practice ◽  
Online Teaching ◽  
Teaching And Learning ◽  
Empirical Work ◽  
Theoretical Framework ◽  
Future Research ◽  
Online Teaching And Learning ◽  
Integrative Research

After presenting a brief overview of the key elements that underpin Etienne Wenger’s communities of practice (CoP) theoretical framework, one of the most widely cited and influential conceptions of social learning, this paper reviews extant empirical work grounded in this framework to investigate online/blended learning in higher education and in professional development. The review is based on integrative research approaches, using quantitative and qualitative analysis, and includes CoP oriented research articles published between 2000 and 2014. Findings are presented under three questions: Which research studies within the online/blended learning literature made central use of the CoP framework? Among those studies identified, which ones established strong linkages between the CoP framework and their findings? Within this last group of identified studies, what do the patterns in their use of the CoP framework suggest as opportunities for future research in online teaching and learning?

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