scholarly journals Functional beverages improve insulin resistance and hepatic steatosis modulating lysophospholipids in diet‐induced obese rats

2021 ◽  
Vol 9 (4) ◽  
pp. 1961-1971
Author(s):  
Julio C. Rubio‐Rodríguez ◽  
Rosalia Reynoso‐Camacho ◽  
Nuria Rocha‐Guzmán ◽  
Luis M. Salgado
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Improve Insulin Resistance ◽  
Obese Rats ◽  
Functional Beverages

Botryosphaeran reduces obesity, hepatic steatosis, dyslipidaemia, insulin resistance and glucose intolerance in diet-induced obese rats

Life Sciences ◽  
2018 ◽  
Vol 211 ◽  
pp. 147-156 ◽  
Author(s):  
Amadeu Z. Silva ◽  
Felipe P.L. Costa ◽  
Ingrid L. Souza ◽  
Mariana C. Ribeiro ◽  
Morenna Alana Giordani ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Glucose Intolerance ◽  
Obese Rats

scholarly journals Effects and mechanisms of caffeine to improve immunological and metabolic abnormalities in diet-induced obese rats

2018 ◽  
Vol 314 (5) ◽  
pp. E433-E447 ◽  
Author(s):  
Chih-Wei Liu ◽  
Hung-Cheng Tsai ◽  
Chia-Chang Huang ◽  
Chang-Youh Tsai ◽  
Yen-Bo Su ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Fatty Acid Synthase ◽  
Molecular Mechanisms ◽  
Immune Cell ◽  
Ex Vivo ◽  
Intercellular Adhesion Molecule ◽  
Metabolic Abnormalities ◽  
Caffeine Treatment ◽  
Obese Rats

In obesity, there are no effective therapies for parallel immune and metabolic abnormalities, including systemic/tissue insulin-resistance/inflammation, adiposity and hepatic steatosis. Caffeine has anti-inflammation, antihepatic steatosis, and anti-insulin resistance effects. In this study, we evaluated the effects and molecular mechanisms of 6 wk of caffeine treatment (HFD-caf) on immunological and metabolic abnormalities of high-fat diet (HFD)-induced obese rats. Compared with HFD vehicle (HFD-V) rats, in HFD-caf rats the suppressed circulating immune cell inflammatory [TNFα, MCP-1, IL-6, intercellular adhesion molecule 1 (ICAM-1), and nitrite] profiles were accompanied by decreased liver, white adipose tissue (WAT), and muscle macrophages and their intracellular cytokine levels. Metabolically, the increase in metabolic rates reduced lipid accumulation in various tissues, resulting in reduced adiposity, lower fat mass, decreased body weight, amelioration of hepatic steatosis, and improved systemic/muscle insulin resistance. Further mechanistic approaches revealed an upregulation of tissue lipogenic [(SREBP1c, fatty acid synthase, acetyl-CoA carboxylase)/insulin-sensitizing (GLUT4 and p-IRS1)] markers in HFD-caf rats. Significantly, ex vivo experiments revealed that the cytokine release by the cocultured peripheral blood mononuclear cell (monocyte) and WAT (adipocyte), which are known to stimulate macrophage migration and hepatocyte lipogenesis, were lower in HFD-V groups than HFD-caf groups. Caffeine treatment simultaneously ameliorates immune and metabolic pathogenic signals present in tissue to normalize immunolgical and metabolic abnormalities found in HFD-induced obese rats.

Ping-tang Recipe (平糖方) improves insulin resistance and attenuates hepatic steatosis in high-fat diet-induced obese rats

2012 ◽  
Vol 18 (4) ◽  
pp. 262-268 ◽  
Author(s):  
Shu-yu Yang ◽  
Neng-jiang Zhao ◽  
Xue-jun Li ◽  
Hui-jie Zhang ◽  
Ke-ji Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
High Fat ◽  
Obese Rats

Polyphenol-rich peach (Prunus persica L.) by-product exerts a greater beneficial effect than dietary fiber-rich by-product on insulin resistance and hepatic steatosis in obese rats

2018 ◽  
Vol 45 ◽  
pp. 58-66 ◽  
Author(s):  
Sarahí Rodríguez-González ◽  
Iza F. Pérez-Ramírez ◽  
Diana M. Amaya-Cruz ◽  
Marco A. Gallegos-Corona ◽  
Minerva Ramos-Gomez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Beneficial Effect ◽  
Dietary Fiber ◽  
Hepatic Steatosis ◽  
Prunus Persica ◽  
Obese Rats

scholarly journals Climbing exercise training does not improve insulin resistance in high‐fat diet‐induced obese rats

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Megumi Maeda ◽  
Takako Fujii ◽  
Yuki Tai ◽  
Koji Okamura
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
High Fat Diet ◽  
High Fat ◽  
Improve Insulin Resistance ◽  
Obese Rats

scholarly journals Effect of carvedilol versus nebivolol on insulin resistance among non-diabetic, non-ischemic cardiomyopathy with heart failure

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Yasser Gaber Metwally ◽  
Heba Kamal Sedrak ◽  
Inass Fahiem Shaltout
Keyword(s):  
Heart Failure ◽  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Ischemic Cardiomyopathy ◽  
Diabetic Patients ◽  
Promising Strategy ◽  
Improve Insulin Resistance ◽  
First Choice ◽  
The Difference

Abstract Background Although B-blockers provide unequivocal benefits in heart failure (HF) management, some B-blockers worsen insulin resistance. It will be a promising strategy to recruit such a B blocker that did not worsen or can even improve insulin resistance (IR). So, this study aimed to assess the effect of two of the third-generation B-blockers (carvedilol versus nebivolol) on insulin sensitivity state in non-diabetic patients with non-ischemic cardiomyopathy with heart failure. Results Out of 43 patients enrolled, 58.1% represented the carvedilol group while 41.9% represented the nebivolol group. Nebivolol improves insulin resistance-related variables (fasting glucose, fasting insulin, and HOMA-IR; P < 0.001, 0.01, and 0.01 respectively). The percentage of change at homeostasis model of assessment (HOMA-IR), indicative of insulin sensitivity status, between baseline versus at 3-months follow-up level of intra-group comparison was increased by 4.58% in the carvedilol arm whereas it was decreased by 11.67% in the nebivolol arm, and the difference on the intragroup level of comparison was significant (P < 0.001 and 0.01 respectively). Conclusion Nebivolol improves insulin resistance-related variables .Nebivolol may be recommended as the B blocker of the first choice for those with non-ischemic cardiomyopathy heart failure with evident insulin resistance; however, larger scaled prospective multicenter randomized trials are needed for confirming our favorable results.

scholarly journals INSIGHTS INTO THE ROLE OF MORUS ALBA IN REVERSING OBESITY-ASSOCIATED HEPATIC STEATOSIS AND RELATED METABOLIC DISORDER IN RATS

2016 ◽  
pp. 231
Author(s):  
Hanaa H. Ahmed ◽  
Fatehya M Metwally ◽  
Hend Rashad ◽  
Asmaa M Zaazaa
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Metabolic Disorder ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Morus Alba ◽  
The Other ◽  
Obese Group ◽  
Control Group

<p>ABSTRACT<br />Objective: The goal of the present study was to examine the viability of Morus alba (M. alba) ethanolic extract in repression of obesity-associated<br />hepatic steatosis and related metabolic disorder; dyslipidemia, hyperinsulinemia, and glycemic status.<br />Methods: Adult female albino rats were randomly assigned into four groups, eight rats each as follows: Group (1) control group received standard<br />rodent diet for 24 weeks. The other three groups administered high cholesterol diet for 12 weeks and served as obese group, M. alba-treated group,<br />and simvastatin-treated group.<br />Results: The current results showed an increment in thoracic circumference (TCX) and abdominal circumferences (AC) as well as body mass index<br />(BMI) in obese group. In addition, dyslipidemia, hyperinsulinemia, hyperglycemia, and insulin resistance have been elucidated in obese group.<br />Moreover, hepatic malondialdehyde (MDA), nitric oxide (NO), serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin<br />values were significantly increased in obese groups versus control group. On the other hand, administration of ethanolic extract of Morus alba or<br />simvastatin could significantly lessen BMI and in addition to improve dyslipidemia in obese group. Glucose, insulin levels, and insulin resistance value<br />in serum samples demonstrated a significant reduction in obese group upon treatment with M. alba ethanolic extract or simvastatin. Furthermore,<br />noticeable depletion in hepatic MDA, NO contents, serum ALT, AST activities, and serum bilirubin level was recorded as a result of treatment with<br />either ethanolic extract of M. alba or simvastatin. Histopathological examination of liver tissue showed ballooning degeneration in the hepatocytes<br />(hepatic steatosis) associated with inflammatory cells penetration in portal zone in obese group. Meanwhile, the treatment of obese groups with<br />ethanolic extract of M. alba or simvastatin was found to restore the structural organization of the liver.<br />Conclusion: The present findings provide a novel aspect for understanding of the role of M. alba against obesity-associated liver diseases and related<br />metabolic disorder. The mechanisms underlying these effects seem to depend on the hypolipidemic potential, anti-inflammatory property, and<br />antioxidant activity of its phytochemicals.<br />Keywords: Obesity, Morus alba, Dyslipidemia, Hyperinsulinemia, Hyperglycemia, Hepatic steatosis.</p>

scholarly journals Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice

2014 ◽  
Vol 32 (4) ◽  
pp. 1200-1209 ◽  
Author(s):  
Yongjie Ma ◽  
Mingming Gao ◽  
Dexi Liu
Keyword(s):  
Insulin Resistance ◽  
Chlorogenic Acid ◽  
Hepatic Steatosis ◽  
High Fat Diet ◽  
High Fat

scholarly journals Ethnic differences in hepatic steatosis: An insulin resistance paradox?

Hepatology ◽  
2008 ◽  
Vol 49 (3) ◽  
pp. 791-801 ◽  
Author(s):  
Richard Guerrero ◽  
Gloria L. Vega ◽  
Scott M. Grundy ◽  
Jeffrey D. Browning
Keyword(s):  
Insulin Resistance ◽  
Hepatic Steatosis ◽  
Ethnic Differences
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