scholarly journals A cross-sectional investigation of breast density and insulin-like growth factor I

2003 ◽  
Vol 107 (6) ◽  
pp. 991-996 ◽  
Author(s):  
Gertraud Maskarinec ◽  
Andrew E. Williams ◽  
Rudolph Kaaks
Keyword(s):  
Growth Factor ◽  
Breast Density ◽  
Insulin Like Growth Factor ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I

scholarly journals Role of Nutritional Status in the Regulation of Adrenarche1

1999 ◽  
Vol 84 (11) ◽  
pp. 3936-3944
Author(s):  
Thomas Remer ◽  
Friedrich Manz
Keyword(s):  
Growth Factor ◽  
Nutritional Status ◽  
Healthy Children ◽  
Insulin Like Growth Factor ◽  
Adrenal Androgen ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I ◽  
Excretion Rates

The factors regulating adrenarche are unknown. Recent in vitro studies have demonstrated that insulin and insulin-like growth factor I induce major adrenal steroidogenic enzyme genes and increase the production of adrenal androgens. Literature findings strongly suggest that changes in body mass index (BMI) reflect an integrated nonhormonal index of changes in serum levels and/or bioactivities of insulin and insulin-like growth factor I. We therefore longitudinally investigated individual changes in BMI and urinary 24-h excretion rates of dehydroepiandrosterone sulfate (DHEAS) in a prepuberty (PreC; n = 22, 11 boys and 11 girls) and a puberty (PubC; n = 20, 10 boys and 10 girls) cohort of healthy children. Twenty-four-hour urine samples were collected at yearly intervals during observation periods that lasted at least 4 yr (comprising ≥5 consecutive 24-h urine collections). For 4-yr intervals highly significant tracking coefficients (P < 0.001) of 0.73 (PreC) and 0.93 (PubC) were observed for DHEAS, emphasizing the importance of individual (and genetic) influences on adrenal androgen excretion. In both cohorts almost 3-fold higher median increases in urinary DHEAS excretion rates (P < 0.05) were observed during the 1-yr period of the individually highest rises in BMI compared with the 1-yr period of significantly lower rises in BMI (P < 0.01) in the same children after the factor age was controlled for. However, no consistently significant associations were found between urinary DHEAS output and BMI from simple cross-sectional correlations at defined age points. These findings provide the first in vivo evidence that a change in the nutritional status, measurable in the form of Δ-BMI (but not BMI alone), is an important physiological regulator of adrenarche regardless of individual adrenal androgen excretion level, age, and developmental stage.

Somatomedins in Adolescence: A Cross-Sectional Study of the Effect of Puberty on Plasma Insulin-Like Growth Factor I and II Levels*

1983 ◽  
Vol 57 (2) ◽  
pp. 268-271 ◽  
Author(s):  
ALICE M. LUNA ◽  
DARRELL M. WILSON ◽  
CHARLES J. WIBBELSMAN ◽  
RICHARD C. BROWN ◽  
RAYMOND J. NAGASHIMA ◽  
...  
Keyword(s):  
Growth Factor ◽  
Plasma Insulin ◽  
Cross Sectional Study ◽  
Insulin Like Growth Factor ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factor I ◽  
Growth Factor I

scholarly journals Premenopausal Insulin-Like Growth Factor-I Serum Levels and Changes in Breast Density over Menopause

2007 ◽  
Vol 16 (3) ◽  
pp. 451-457 ◽  
Author(s):  
Martijn Verheus ◽  
Petra H.M. Peeters ◽  
Rudolf Kaaks ◽  
Paulus A.H. van Noord ◽  
Diederick E. Grobbee ◽  
...  
Keyword(s):  
Growth Factor ◽  
Breast Density ◽  
Serum Levels ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

scholarly journals KORELASI KADAR INSULIN-LIKE GROWTH FACTOR I (IGF-I) SERUM MATERNAL DENGAN ANTROPOMETRI BAYI BARU LAHIR

2017 ◽  
Vol 8 (2) ◽  
pp. 53
Author(s):  
Lita Angelina Saputri
Keyword(s):  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Factor I ◽  
Igf I ◽  
Kolmogorov Smirnov ◽  
Growth Factor I

Pertumbuhan intrauterin yang tidak optimal dapat menyebabkan bayi lahir dengan berat badan, panjang badan dan lingkar kepala kecil. Keadaan ini dipengaruhi oleh berbagai faktor salah satunya Insulin-like Growth Factor I (IGF-I). Insulin-like Growth Factor I maternal berperan penting dalam transpor nutrisi dan ibu ke janin melalui plasenta. Kadar IGF-I maternal diduga berkorelasi positif dengan antropometri bayi baru lahir. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar IGF-I maternal dengan antropometri bayi baru lahir. Disain penelitian adalah cross sectional,observasional terhadap 56 ibu melahirkan di RSUD Dr. Rasidin, RS Tk III Reksodiwiryo Padang  bulan Juni sampai Agustus 2015 dengan teknik consecutive sampling. Kadar IGF-I diukur dengan menggunakan metode ELISA di Laboratorium Biomedik Universitas Andalas. Uji normalitas data dengan Kolmogorov-Smirnov, uji Spearman untuk korelasi IGF-I dengan berat badan, panjang badan dan lingkar kepala bayi baru lahir dan uji Mann-Whitney untuk menilai perbedaan kadar IGF-I. Hasil penelitian menunjukkan median kadar IGF-I maternal adalah 219,42 (203,46-267,18) ng/ml, berat badan badan 3100 (2100-4300) gram, panjang badan 48 (44-50) cm dan lingkar kepala 34 (31,5-37,5) cm. Terdapat korelasi positif yang lemah dan tidak signifikan antara IGF-I maternal dengan berat badan (r=0,206, p=0,128), dan terdapat korelasi positif yang sangat lemah dan tidak signifikan antara IGF-I maternal dengan panjang badan (r=0,186, p=0,170) dan lingkar kepala (r=0,160, p=0,238). Kesimpulan penelitian ini adalah terdapat korelasi positif yang tidak signifikan antara kadar IGF-I serum maternal dengan antropometri bayi baru lahir.

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